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Gene Review

SACM1L  -  SAC1 suppressor of actin mutations 1-like...

Homo sapiens

Synonyms: KIAA0851, Phosphatidylinositide phosphatase SAC1, SAC1, Suppressor of actin mutations 1-like protein
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Disease relevance of SACM1L


High impact information on SACM1L


Biological context of SACM1L

  • Finally, rat Sac1 expression in Deltasac1 yeast strains complements a wide phenotypes associated with Sac1p insufficiency [4].

Anatomical context of SACM1L

  • Thus, yeast Sac1p and rat Sac1 are integral membrane lipid phosphatases that play evolutionary conserved roles in eukaryotic cell physiology [4].
  • Rat Sac1 is a ubiquitously expressed 65-kDa integral membrane protein of the endoplasmic reticulum that is found at particularly high levels in cerebellar Purkinje cells [4].
  • To examine these control mechanisms, the B cell responses to 4 mitogens (pokeweed, wheat germ agglutinin, lipopolysaccharide, and SAC-1), which are known to stimulate B cells by different mechanisms, were measured in two groups of stable long-term (greater than 1 year post-transplant) renal transplant recipients [5].
  • The action of PWM and SAC1 on cord blood MNC can each be replaced by conditioned media [1].

Associations of SACM1L with chemical compounds

  • Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activity [4].
  • The influence of amino acids and their derivatives on the formation of SAC14 from SAC1 and C4 were investigated [6].

Analytical, diagnostic and therapeutic context of SACM1L

  • DNA obtained from British Caucasoids with IgAN (N = 75), MN (N = 43), and normal controls (N = 73), was digested with the restriction enzyme Sac1, and studied using Southern blot techniques and hybridization with a 32P labelled DNA probe homologous to S mu [7].
  • The bZP2 cDNA (115-1914 nt, 1.8 kb), excluding sequences coding for N-terminal signal sequence and C-terminal transmembranelike domain, was PCR amplified and Sac1-Sal1 restricted fragment cloned in frame downstream of the T5 promoter under the lac operator control in a pQE-30 vector [8].


  1. Cord blood B cell differentiation. Synergistic effect of pokeweed mitogen and Staphylococcus aureus on in vitro differentiation of B cells from human neonates. Miller, K.M., Pittard, W.B., Sorensen, R.U. Clin. Exp. Immunol. (1984) [Pubmed]
  2. The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex. Rohde, H.M., Cheong, F.Y., Konrad, G., Paiha, K., Mayinger, P., Boehmelt, G. J. Biol. Chem. (2003) [Pubmed]
  3. Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals. Nemoto, Y., Wenk, M.R., Watanabe, M., Daniell, L., Murakami, T., Ringstad, N., Yamada, H., Takei, K., De Camilli, P. J. Biol. Chem. (2001) [Pubmed]
  4. Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activity. Nemoto, Y., Kearns, B.G., Wenk, M.R., Chen, H., Mori, K., Alb, J.G., De Camilli, P., Bankaitis, V.A. J. Biol. Chem. (2000) [Pubmed]
  5. Pretransplant crossmatch status and immunoglobulin production in renal transplant recipients. Cardella, C.J., Ng, C.M., Jephthab-Ochola, J., Perera, M.A., Klein, M.H. Transplantation (1987) [Pubmed]
  6. Influence of aromatic compounds on the interaction of activated C4 with EAC1. Baba, A.S., Tamura, N. Immunology (1977) [Pubmed]
  7. Immunoglobulin heavy chain switch region gene polymorphisms in glomerulonephritis. Moore, R.H., Hitman, G.A., Sinico, R.A., Mustonen, J., Medcraft, J., Lucas, E.Y., Richards, N.T., Venning, M.C., Cunningham, J., Marsh, F.P. Kidney Int. (1990) [Pubmed]
  8. Molecular cloning and expression in Escherichia coli of cDNA encoding bonnet monkey (Macaca radiata) zona pellucida glycoprotein-ZP2. Jethanandani, P., Santhanam, R., Gupta, S.K. Mol. Reprod. Dev. (1998) [Pubmed]
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