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Gene Review

EXOC7  -  exocyst complex component 7

Homo sapiens

Synonyms: 2-5-3p, EX070, EXO70, EXOC1, Exo70p, ...
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High impact information on EXOC7


Biological context of EXOC7


Anatomical context of EXOC7


Associations of EXOC7 with chemical compounds

  • In cells incubated with brefeldin A, most of the BIG2, Exo70, and trans-Golgi protein p230 were widely dispersed from their perinuclear concentrations, but small amounts always remained, apparently at the MTOC [6].

Physical interactions of EXOC7

  • Moreover, Exo70p co-immunoprecipitates FIP3 and FIP4 [4].
  • Here we present the structures of the Exo70p subunit of this complex and of the C-terminal domains of Exo84p, at 2.0-A and 2.85-A resolution, respectively [7].

Other interactions of EXOC7

  • By immunofluorescence microscopy, endogenous BIG2 and Exo70 in HepG2 cells were visualized at Golgi membranes and apparently at the microtubule-organizing center (MTOC) [6].
  • Exo70p, a component of the Exocyst complex, also localises to the furrow of dividing cells and interacts with Arf6 [4].
  • The structure of the C-terminal domain of the exocyst subunit Sec6p reveals multiple helical bundles, which are structurally and topologically similar to Exo70p and the C-terminal domains of Exo84p and Sec15, despite <10% sequence identity [8].
  • The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif [7].


  1. The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. Inoue, M., Chang, L., Hwang, J., Chiang, S.H., Saltiel, A.R. Nature (2003) [Pubmed]
  2. Exo70 interacts with the Arp2/3 complex and regulates cell migration. Zuo, X., Zhang, J., Zhang, Y., Hsu, S.C., Zhou, D., Guo, W. Nat. Cell Biol. (2006) [Pubmed]
  3. Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. Gerges, N.Z., Backos, D.S., Rupasinghe, C.N., Spaller, M.R., Esteban, J.A. EMBO J. (2006) [Pubmed]
  4. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. Fielding, A.B., Schonteich, E., Matheson, J., Wilson, G., Yu, X., Hickson, G.R., Srivastava, S., Baldwin, S.A., Prekeris, R., Gould, G.W. EMBO J. (2005) [Pubmed]
  5. Dietary omega-3 fatty acid supply influences mechanisms controlling body weight and glucose metabolism. Jayasooriya, A.P., Weisinger, R.S., Weisinger, H.S., Mathai, M., Puskas, L., Kitajka, K., Dashti, M., Egan, G., Sinclair, A.J. Asia Pacific journal of clinical nutrition. (2004) [Pubmed]
  6. Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70. Xu, K.F., Shen, X., Li, H., Pacheco-Rodriguez, G., Moss, J., Vaughan, M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif. Dong, G., Hutagalung, A.H., Fu, C., Novick, P., Reinisch, K.M. Nat. Struct. Mol. Biol. (2005) [Pubmed]
  8. The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles. Sivaram, M.V., Furgason, M.L., Brewer, D.N., Munson, M. Nat. Struct. Mol. Biol. (2006) [Pubmed]
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