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Gene Review

Sspo  -  SCO-spondin

Mus musculus

Synonyms: C79529, Scospondin
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Psychiatry related information on Sspo


High impact information on Sspo


Biological context of Sspo

  • The mouse SCO-spondin coding sequence was searched by alignement of the coding bovine SCO-spondin sequence with the mouse whole genome shotgun (WGS) supercontig (NW 000250) [5].
  • In addition, the mouse SCO-spondin gene was located at chromosome 6, between marker D6Mit352 and D6Mit119, in a conserved syntenic region [5].
  • The presence of these domains strongly suggests the SCO-spondin involvement in cellular events occurring during placental development and physiology [1].
  • In order to define this new role of SCO-spondin during development, we demonstrated its expression at relevant steps of gestation in human and mouse placenta, using RT-PCR, immunohistochemistry and Western-blot experiments [1].
  • The analysis of this consensus sequence is consistent with a very high degree of conservation in the amino acids composition and multidomain organization of SCO-spondin in mammals [2].

Anatomical context of Sspo

  • SCO-spondin is specifically expressed in the subcommissural organ (SCO), a secretory ependymal differentiation lining the roof of the third ventricular cavity of the brain [5].
  • When released into the cerebro-spinal fluid (CSF), SCO-spondin aggregates and forms Reissner's fiber (RF), a structure present in the central canal of the spinal cord [5].

Associations of Sspo with chemical compounds

  • Although the cultured SCO displayed dopamine receptors, dopamine had no apparent effect on the expression of the SCO-spondin gene/protein or on the release of RF-glycoproteins (SCO-spondin included) by SCO explants, suggesting that dopamine affects the function(s) of the SCO differently from the secretion of RF-glycoproteins [6].


  1. Placental expression of SCO-spondin during mouse and human development. Gonçalves-Mendes, N., Blanchon, L., Meiniel, A., Dastugue, B., Sapin, V. Gene Expr. Patterns (2004) [Pubmed]
  2. The complex multidomain organization of SCO-spondin protein is highly conserved in mammals. Meiniel, O., Meiniel, A. Brain Res. Brain Res. Rev. (2007) [Pubmed]
  3. The secretory ependymal cells of the subcommissural organ: Which role in hydrocephalus? Meiniel, A. Int. J. Biochem. Cell Biol. (2007) [Pubmed]
  4. A deficiency in RFX3 causes hydrocephalus associated with abnormal differentiation of ependymal cells. Baas, D., Meiniel, A., Benadiba, C., Bonnafe, E., Meiniel, O., Reith, W., Durand, B. Eur. J. Neurosci. (2006) [Pubmed]
  5. Mouse SCO-spondin, a gene of the thrombospondin type 1 repeat (TSR) superfamily expressed in the brain. Gonçalves-Mendes, N., Simon-Chazottes, D., Creveaux, I., Meiniel, A., Guénet, J.L., Meiniel, R. Gene (2003) [Pubmed]
  6. The subcommissural organ expresses D2, D3, D4, and D5 dopamine receptors. Tomé, M., Jiménez, A.J., Richter, H., Vio, K., Bermúdez-Silva, F.J., Rodríguez, E.M., Pérez-Fígares, J.M. Cell Tissue Res. (2004) [Pubmed]
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