The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Sspo  -  SCO-spondin

Mus musculus

Synonyms: C79529, Scospondin
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Psychiatry related information on Sspo

 

High impact information on Sspo

 

Biological context of Sspo

  • The mouse SCO-spondin coding sequence was searched by alignement of the coding bovine SCO-spondin sequence with the mouse whole genome shotgun (WGS) supercontig (NW 000250) [5].
  • In addition, the mouse SCO-spondin gene was located at chromosome 6, between marker D6Mit352 and D6Mit119, in a conserved syntenic region [5].
  • The presence of these domains strongly suggests the SCO-spondin involvement in cellular events occurring during placental development and physiology [1].
  • In order to define this new role of SCO-spondin during development, we demonstrated its expression at relevant steps of gestation in human and mouse placenta, using RT-PCR, immunohistochemistry and Western-blot experiments [1].
  • The analysis of this consensus sequence is consistent with a very high degree of conservation in the amino acids composition and multidomain organization of SCO-spondin in mammals [2].
 

Anatomical context of Sspo

  • SCO-spondin is specifically expressed in the subcommissural organ (SCO), a secretory ependymal differentiation lining the roof of the third ventricular cavity of the brain [5].
  • When released into the cerebro-spinal fluid (CSF), SCO-spondin aggregates and forms Reissner's fiber (RF), a structure present in the central canal of the spinal cord [5].
 

Associations of Sspo with chemical compounds

  • Although the cultured SCO displayed dopamine receptors, dopamine had no apparent effect on the expression of the SCO-spondin gene/protein or on the release of RF-glycoproteins (SCO-spondin included) by SCO explants, suggesting that dopamine affects the function(s) of the SCO differently from the secretion of RF-glycoproteins [6].

References

  1. Placental expression of SCO-spondin during mouse and human development. Gonçalves-Mendes, N., Blanchon, L., Meiniel, A., Dastugue, B., Sapin, V. Gene Expr. Patterns (2004) [Pubmed]
  2. The complex multidomain organization of SCO-spondin protein is highly conserved in mammals. Meiniel, O., Meiniel, A. Brain Res. Brain Res. Rev. (2007) [Pubmed]
  3. The secretory ependymal cells of the subcommissural organ: Which role in hydrocephalus? Meiniel, A. Int. J. Biochem. Cell Biol. (2007) [Pubmed]
  4. A deficiency in RFX3 causes hydrocephalus associated with abnormal differentiation of ependymal cells. Baas, D., Meiniel, A., Benadiba, C., Bonnafe, E., Meiniel, O., Reith, W., Durand, B. Eur. J. Neurosci. (2006) [Pubmed]
  5. Mouse SCO-spondin, a gene of the thrombospondin type 1 repeat (TSR) superfamily expressed in the brain. Gonçalves-Mendes, N., Simon-Chazottes, D., Creveaux, I., Meiniel, A., Guénet, J.L., Meiniel, R. Gene (2003) [Pubmed]
  6. The subcommissural organ expresses D2, D3, D4, and D5 dopamine receptors. Tomé, M., Jiménez, A.J., Richter, H., Vio, K., Bermúdez-Silva, F.J., Rodríguez, E.M., Pérez-Fígares, J.M. Cell Tissue Res. (2004) [Pubmed]
 
WikiGenes - Universities