Disease relevance of Subcommissural Organ

• The subcommissural organ is not highly permeable and does not have fenestrated capillaries, but new evidence indicates that it may be involved in the hypertension produced by aldosterone acting on the brain [1].

High impact information on Subcommissural Organ

• Comparison with the phenotype of Wnt1(sw/sw) (swaying) mutants suggests that subcommissural organ failure is the main cause of prenatal hydrocephalus observed in both strains [2].
• SCO-spondin is a large glycoprotein secreted by ependymal cells of the subcommissural organ [3].
• SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation [4].
• Spontaneous congenital hydrocephalus in the mutant mouse hyh. Changes in the ventricular system and the subcommissural organ [5].
• In situ hybridization studies revealed the presence of the bradykinin-potentiating peptides precursor mRNAs in distinct regions of the B. jararaca brain, such as the ventromedial hypothalamus, the paraventricular nuclei, the paraventricular organ, and the subcommissural organ [6].

Biological context of Subcommissural Organ

• Transcription of SCO-spondin in the subcommissural organ: evidence for down-regulation mediated by serotonin [7].
• Morphologic consequences of serotonin neurotoxin administration: neuron-target cell interaction in the rat subcommissural organ [8].
• The secretory activity of the subcommissural organ (SCO) was studied during embryogenesis of the chick (Gallus gallus) using two lectins labelled with fluorescein isothiocyanate, concanavalin A (Con A) and wheat-germ agglutinin (WGA) [9].

Anatomical context of Subcommissural Organ

• It is concluded that the subcommissural organ represents, in addition to the pineal and the fetal neurohypophysis, another significant source of arginine vasotocin in the mammalian central nervous system [10].
• The subfornical organ, the organon vasculosum lamia terminalis, the subcommissural organ, the area postrema all contained significant quantities of both releasing factors [11].
• This extracellular matrix glycoprotein of 4,560 amino acids is expressed and secreted early in development by the subcommissural organ (SCO), an ependymal differentiation located in the roof of the Sylvian aqueduct [12].
• In contrast, a few other regions, such as the pineal gland and the subcommissural organ, showed a high concentration of ANF-like immunoreactivity but did not contain ANF-binding sites [13].
• The study revealed that Msx1 is strongly expressed in the circumventricular organs, such as the subcommissural organ and choroid plexus, and in some epithelia, such as that of the dorsal, but not the ventral part of the third ventricle [14].

Associations of Subcommissural Organ with chemical compounds

• There was no detectable arginine vasopressin or oxytocin in subcommissural organ extracts [10].
• Arginine vasotocin in the rabbit subcommissural organ [10].
• This hypothesis is in line with the inhibitory effect postulated for the serotoninergic innervation in the rat subcommissural organ in early investigations using serotonin neurotoxins [15].
• The subcommissural organ of the frog Rana perezi is innervated by nerve fibres containing GABA [16].
• Two different types of ependymal cells were found in the subcommissural organ (SCO) of Natrix maura [17].

Gene context of Subcommissural Organ

• Msx1-deficient mice fail to form prosomere 1 derivatives, subcommissural organ, and posterior commissure and develop hydrocephalus [18].
• The transcription factor Pax6 is required for development of the diencephalic dorsal midline secretory radial glia that form the subcommissural organ [19].
• No differences in GR or MR mRNA expression were found in the OVLT, subcommissural organ, area postrema or nucleus tractus solitarius [20].
• SCO-spondin corresponds to glycoproteins secreted by the subcommissural organ (SCO), an ependymal differentiation of the vertebrate brain located at the entrance to the Sylvian aqueduct [4].
• SCO-spondin is specifically expressed in the subcommissural organ (SCO), a secretory ependymal differentiation lining the roof of the third ventricular cavity of the brain [21].

Analytical, diagnostic and therapeutic context of Subcommissural Organ

• The presence of vasotocin, vasopressin and oxytocin in the pineal gland, subcommissural organ and fetal neurohypophysis was therefore investigated, using three specific radioimmunoassays [22].
• The innervation of the frog subcommissural organ was studied by light-microscopic and ultrastructural immunocytochemistry using antisera against serotonin, noradrenaline, dopamine, gamma-aminobutyric acid (GABA), glutamic acid decarboxylase, different GABA receptor subunits and bovine Reissner's fibre material (AFRU) [16].
• Immuno-electron microscopy specifically enhanced with silver staining has been used to demonstrate the localization of calcitonin gene-related peptide (CGRP) in the ependymocytes of the hamster subcommissural organ (SCO) [23].
• The subcommissural organ (SCO) of the golden hamster (Mesocricetus auratus) was studied by conventional electron microscopy, freeze-fracture technique, zinc-iodide-osmium (ZIO) and acid phosphatase cytochemical reactions [24].

References