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Gsta1  -  glutathione S-transferase alpha 1

Rattus norvegicus

Synonyms: Gsta3, Gsta5, Yc1
 
 
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High impact information on Gsta3

 

Biological context of Gsta3

 

Anatomical context of Gsta3

  • Identification of the Yc1 glutathione S-transferase mRNA as the overexpressed species in a nitrogen mustard-resistant rat mammary carcinoma cell line [4].
  • In 60-day-old animals, the concentrations of Alpha-class GST subunits 2 (Yc1; 5.0-fold) and 8 (Yk; 3.0-fold), Mu-class subunit 11 (Yo; 2.5-fold) and Pi-class subunit 7 (Yp; 2.0-fold) were increased in all regions of cerebellar cortex of jaundiced animals [5].
  • Increased resistance to nitrogen mustards and antifolates following in vitro selection of murine fibroblasts and primary hematopoietic cells transduced with a bicistronic retroviral vector expressing the rat glutathione S-transferase A3 and a mutant dihydrofolate reductase [6].
 

Associations of Gsta3 with chemical compounds

  • Although evidence suggests that induction of Yc2 is responsible for the high detoxification capacity of livers from ethoxyquin-treated rats for AFB1-8,9-epoxide, resistance towards AFB1 may be multifactorial in this instance as dietary ethoxyquin also induces the Ya1, Ya2 and Yc1 subunits about 2.2-, 10.9- and 2.7-fold respectively [7].
  • The rat Yc1 isozyme had specific activities toward 1-chloro-2,4-dinitrobenzene, cumene hydroperoxide and ethacrynic acid of 10.7, 0.98 and 0.92 mumol/mg/min, respectively, whereas the mouse Yc isozyme had specific activities of 5.7, 2.1 and 0.1 mumol/mg/min for these substrates, respectively [8].
  • Coexpression of rat glutathione S-transferase A3 and human cytidine deaminase by a bicistronic retroviral vector confers in vitro resistance to nitrogen mustards and cytosine arabinoside in murine fibroblasts [9].
  • Formation of acetaldehyde adducts of glutathione S-transferase A3 in the liver of rats administered alcohol chronically [10].
 

Other interactions of Gsta3

  • As these two GSTs possess less than 70% sequence identity with the Ya1 and Ya2 subunits, both of Mr 25,500, the constitutively expressed Yc subunit of Mr 27,500 has been renamed Yc1 and the ethoxyquin-inducible GST of Mr 25,800 has been designated Yc2 [7].
  • The second cluster of genes is the glutathione S-transferase-A3-like genes, which include aflatoxin B1 aldehyde reductase and aldehyde oxidase [11].
 

Analytical, diagnostic and therapeutic context of Gsta3

  • A maximal reduction in GST Ya, Yb1/2, and Yc1 mRNA levels was also noted at 18 hr after treatment with GdCl3, followed by a gradual return to levels in untreated rats at later time points [12].

References

  1. Enhancement of radiation-inducible hepatic glutathione-S-transferases Ya, Yb1, Yb2, Yc1, and Yc2 gene expression by oltipraz: possible role in radioprotection. Kim, S.G., Nam, S.Y., Kim, C.W., Kim, J.H., Cho, C.K., Yoo, S.Y. Mol. Pharmacol. (1997) [Pubmed]
  2. Genomic cloning and characterization of the rat glutathione S-transferase-A3-subunit gene. Fotouhi-Ardakani, N., Batist, G. Biochem. J. (1999) [Pubmed]
  3. The synergistic upregulation of phase II detoxification enzymes by glucosinolate breakdown products in cruciferous vegetables. Nho, C.W., Jeffery, E. Toxicol. Appl. Pharmacol. (2001) [Pubmed]
  4. Identification of the Yc1 glutathione S-transferase mRNA as the overexpressed species in a nitrogen mustard-resistant rat mammary carcinoma cell line. Fotouhi-Ardakani, N., Woo, A., Lewandowska, M., Schecter, R., Batist, G. J. Biochem. Mol. Toxicol. (1998) [Pubmed]
  5. Effects of hyperbilirubinaemia on glutathione S-transferase isoenzymes in cerebellar cortex of the Gunn rat. Johnson, J.A., Hayward, J.J., Kornguth, S.E., Siegel, F.L. Biochem. J. (1993) [Pubmed]
  6. Increased resistance to nitrogen mustards and antifolates following in vitro selection of murine fibroblasts and primary hematopoietic cells transduced with a bicistronic retroviral vector expressing the rat glutathione S-transferase A3 and a mutant dihydrofolate reductase. Belzile, J.P., Karatzas, A., Shiu, H.Y., Létourneau, S., Palerme, J.S., Cournoyer, D. Cancer Gene Ther. (2003) [Pubmed]
  7. Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel alpha-class glutathione S-transferase subunit, Yc2, which possesses high catalytic activity for aflatoxin B1-8,9-epoxide. Hayes, J.D., Judah, D.J., McLellan, L.I., Kerr, L.A., Peacock, S.D., Neal, G.E. Biochem. J. (1991) [Pubmed]
  8. Comparison of the aflatoxin B1-8,9-epoxide conjugating activities of two bacterially expressed alpha class glutathione S-transferase isozymes from mouse and rat. Buetler, T.M., Slone, D., Eaton, D.L. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  9. Coexpression of rat glutathione S-transferase A3 and human cytidine deaminase by a bicistronic retroviral vector confers in vitro resistance to nitrogen mustards and cytosine arabinoside in murine fibroblasts. Létourneau, S., Palerme, J.S., Delisle, J.S., Beauséjour, C.M., Momparler, R.L., Cournoyer, D. Cancer Gene Ther. (2000) [Pubmed]
  10. Formation of acetaldehyde adducts of glutathione S-transferase A3 in the liver of rats administered alcohol chronically. Sultana, R., Raju, B.S., Sharma, V., Reddanna, P., Babu, P.P. Alcohol (2005) [Pubmed]
  11. In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. Hu, R., Hebbar, V., Kim, B.R., Chen, C., Winnik, B., Buckley, B., Soteropoulos, P., Tolias, P., Hart, R.P., Kong, A.N. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  12. Gadolinium chloride inhibition of rat hepatic microsomal epoxide hydrolase and glutathione S-transferase gene expression. Kim, S.G., Choi, S.H. Drug Metab. Dispos. (1997) [Pubmed]
 
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