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Gene Review

Eef1a1  -  eukaryotic translation elongation factor 1...

Rattus norvegicus

Synonyms: EEF-1, EEF1A, EF-1-alpha-1, EF-Tu, EF1A, ...
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Disease relevance of Eef1a1


Psychiatry related information on Eef1a1


High impact information on Eef1a1

  • alpha 2-Adrenergic receptors appear in rat salivary glands after reserpine treatment [8].
  • Microtubule severing by elongation factor 1 alpha [9].
  • Bacterially expressed human EF-1 alpha also displayed microtubule-severing activity in vitro and, when microinjected into fibroblasts, induced rapid and transient fragmentation of cytoplasmic microtubule arrays [9].
  • alpha 2-adrenoceptor-mediated hyperpolarization of locus coeruleus neurons: intracellular studies in vivo [10].
  • Our initial investigation of didemnin B resulted in the discovery of its GTP-dependent binding of the translation elongation factor EF1 alpha [11].

Chemical compound and disease context of Eef1a1


Biological context of Eef1a1


Anatomical context of Eef1a1


Associations of Eef1a1 with chemical compounds

  • We analyzed the co-sedimentation of eEF1A-1 mRNA with polyribosome fractions in sucrose gradients, and found that NGF stimulation enriched the presence of eEF1A-1 mRNA in polyribosomes, indicating that the translation of eEF1A-1 mRNA is regulated by NGF [18].
  • alpha and beta DNA polymerases (DNA nucleotidyltransferase; deoxynucleosidetriphosphate:DNA deoxynucleotidyltransferase, EC were isolated from nuclear and cytoplasmic fractions of rat livers exposed to a carcinogenic regimen with the hepatocarcinogen N-2-fluorenylacetamide and from 24-hr regenerating liver [24].
  • alpha- and beta-Adrenoceptor activities of norepinephrine analogues in isolated tissues of the rat [25].
  • alpha 1-Adrenoceptor stimulation of rat left ventricular papillary muscles by phenylephrine in the presence of propranolol resulted in rapid breakdown of phosphatidylinositol 4,5-bisphosphate (PI-4,5-P2) and a triphasic inotropic response in a concentration-dependent manner [26].
  • In order to evaluate the role of subunit interactions in the Alpha class glutathione S-transferases, inactive GS-Succ-BP-modified GST 1-1 was mixed with unlabeled, active GST 2-2 [27].

Regulatory relationships of Eef1a1


Other interactions of Eef1a1


Analytical, diagnostic and therapeutic context of Eef1a1


  1. Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae. Rambukkana, A., Yamada, H., Zanazzi, G., Mathus, T., Salzer, J.L., Yurchenco, P.D., Campbell, K.P., Fischetti, V.A. Science (1998) [Pubmed]
  2. Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation. Johnson, R.J., Iida, H., Alpers, C.E., Majesky, M.W., Schwartz, S.M., Pritzi, P., Gordon, K., Gown, A.M. J. Clin. Invest. (1991) [Pubmed]
  3. A nuclear pathway for alpha 1-adrenergic receptor signaling in cardiac cells. Ardati, A., Nemer, M. EMBO J. (1993) [Pubmed]
  4. alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Lo Bianco, C., Ridet, J.L., Schneider, B.L., Deglon, N., Aebischer, P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death. Borradaile, N.M., Buhman, K.K., Listenberger, L.L., Magee, C.J., Morimoto, E.T., Ory, D.S., Schaffer, J.E. Mol. Biol. Cell (2006) [Pubmed]
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  7. alpha 1- and alpha 2-adrenoceptors in rat cerebral cortex: effect of frontal lobotomy. Morris, M.J., Elghozi, J.L., Dausse, J.P., Meyer, P. Naunyn Schmiedebergs Arch. Pharmacol. (1981) [Pubmed]
  8. alpha 2-Adrenergic receptors appear in rat salivary glands after reserpine treatment. Bylund, D.B., Martinez, J.R. Nature (1980) [Pubmed]
  9. Microtubule severing by elongation factor 1 alpha. Shiina, N., Gotoh, Y., Kubomura, N., Iwamatsu, A., Nishida, E. Science (1994) [Pubmed]
  10. alpha 2-adrenoceptor-mediated hyperpolarization of locus coeruleus neurons: intracellular studies in vivo. Aghajanian, G.K., VanderMaelen, C.P. Science (1982) [Pubmed]
  11. Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis. Crews, C.M., Lane, W.S., Schreiber, S.L. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  12. Mechanical load opposes angiotensin-mediated decrease in vascular alpha 1-adrenoceptors. Clements, M.L., Faber, J.E. Hypertension (1997) [Pubmed]
  13. Design of two chimaeric human-rat class alpha glutathione transferases for probing the contribution of C-terminal segments of protein structure to the catalytic properties. Björnestedt, R., Widersten, M., Board, P.G., Mannervik, B. Biochem. J. (1992) [Pubmed]
  14. Contraction of the rat isolated aorta caused by Clostridium perfringens alpha toxin (phospholipase C): evidence for the involvement of arachidonic acid metabolism. Fujii, Y., Sakurai, J. Br. J. Pharmacol. (1989) [Pubmed]
  15. Inhibition of alpha 2-adrenergic receptor-mediated cyclic GMP formation by a phorbol ester, a protein kinase C activator. Jaiswal, R.K., Sharma, R.K. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  16. CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo. Menniti, F.S., Buchan, A.M., Chenard, B.L., Critchett, D.J., Ganong, A.H., Guanowsky, V., Seymour, P.A., Welch, W.M. Stroke (2003) [Pubmed]
  17. Characterization of the statin-like S1 and rat elongation factor 1 alpha as two distinctly expressed messages in rat. Ann, D.K., Lin, H.H., Lee, S., Tu, Z.J., Wang, E. J. Biol. Chem. (1992) [Pubmed]
  18. Nerve growth factor specifically stimulates translation of eukaryotic elongation factor 1A-1 (eEF1A-1) mRNA by recruitment to polyribosomes in PC12 cells. Petroulakis, E., Wang, E. J. Biol. Chem. (2002) [Pubmed]
  19. Nucleotide sequence of rat elongation factor-1 alpha cDNA. Shirasawa, T., Sakamoto, K., Akashi, T., Takahashi, H., Kawashima, A. Nucleic Acids Res. (1992) [Pubmed]
  20. Identification of AGE-modified proteins in SH-SY5Y and OLN-93 cells. Langer, A.K., Poon, H.F., Münch, G., Lynn, B.C., Arendt, T., Butterfield, D.A. Neurotoxicity research. (2006) [Pubmed]
  21. Alpha 1-adrenergic receptor stimulation decreases maximum shortening velocity of skinned single ventricular myocytes from rats. Strang, K.T., Moss, R.L. Circ. Res. (1995) [Pubmed]
  22. Rat elongation factor 1 alpha: sequence of cDNA from a highly metastatic fos-transferred cell line. Taniguchi, S., Miyamoto, S., Sadano, H., Kobayashi, H. Nucleic Acids Res. (1991) [Pubmed]
  23. Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation. Tsokas, P., Grace, E.A., Chan, P., Ma, T., Sealfon, S.C., Iyengar, R., Landau, E.M., Blitzer, R.D. J. Neurosci. (2005) [Pubmed]
  24. Decreased fidelity of DNA polymerase activity during N-2-fluorenylacetamide hepatocarcinogenesis. Chan, J.Y., Becker, F.F. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  25. alpha- and beta-Adrenoceptor activities of norepinephrine analogues in isolated tissues of the rat. Drummer, O., Culvenor, A.J., Jarrott, B., Louis, W.J. Circ. Res. (1980) [Pubmed]
  26. Alpha 1-adrenoceptor-mediated phosphoinositide breakdown and inotropic response in rat left ventricular papillary muscles. Otani, H., Otani, H., Das, D.K. Circ. Res. (1988) [Pubmed]
  27. Probing subunit interactions in alpha class rat liver glutathione S-transferase with the photoaffinity label glutathionyl S-[4-(succinimidyl)benzophenone]. Wang, J., Bauman, S., Colman, R.F. J. Biol. Chem. (2000) [Pubmed]
  28. Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension. Pravenec, M., Landa, V., Zídek, V., Musilová, A., Kazdová, L., Qi, N., Wang, J., St Lezin, E., Kurtz, T.W. Physiological research / Academia Scientiarum Bohemoslovaca. (2003) [Pubmed]
  29. alpha- and delta-tocopherol induce expression of hepatic alpha-tocopherol-transfer-protein mRNA. Fechner, H., Schlame, M., Guthmann, F., Stevens, P.A., Rüstow, B. Biochem. J. (1998) [Pubmed]
  30. Presence of translation elongation factor-1A in the rat cerebellar postsynaptic density. Moon, I.S., Cho, S.J., Jung, J.S., Park, I.S., Kim, D.K., Kim, J.T., Ko, B.H., Jin, I. Neurosci. Lett. (2004) [Pubmed]
  31. Enhancement of translation elongation in neurons by brain-derived neurotrophic factor: implications for mammalian target of rapamycin signaling. Inamura, N., Nawa, H., Takei, N. J. Neurochem. (2005) [Pubmed]
  32. Genomic cloning and characterization of the rat glutathione S-transferase-A3-subunit gene. Fotouhi-Ardakani, N., Batist, G. Biochem. J. (1999) [Pubmed]
  33. N-terminal alpha-dystroglycan binds to different extracellular matrix molecules expressed in regenerating peripheral nerves in a protein-mediated manner and promotes neurite extension of PC12 cells. Hall, H., Bozic, D., Michel, K., Hubbell, J.A. Mol. Cell. Neurosci. (2003) [Pubmed]
  34. Inhibition by calponin of isometric force in demembranated vascular smooth muscle strips: the critical role of serine-175. Uyama, Y., Imaizumi, Y., Watanabe, M., Walsh, M.P. Biochem. J. (1996) [Pubmed]
  35. Characteristics of the alpha 2/beta 2-adrenergic receptor-coupled adenylyl cyclase system in rat myometrium during pregnancy. Mhaouty, S., Cohen-Tannoudji, J., Bouet-Alard, R., Limon-Boulez, I., Maltier, J.P., Legrand, C. J. Biol. Chem. (1995) [Pubmed]
  36. Effect of alpha 1-adrenergic blockade on nucleolar growth, chromatin relaxation, and histone H1(0) content in regenerating liver. Rius, E., Pujol, M.J., Agell, N., Bachs, O. Exp. Cell Res. (1993) [Pubmed]
  37. Cellular sources of glutathione S-transferase P in primary cultured rat hepatocytes: localization by in situ hybridization. Lee, S.J., Friedman, S.L., Whalen, R., Boyer, T.D. Biochem. J. (1994) [Pubmed]
  38. Alpha 1-adrenergic receptors in the neural lobe of the rat pituitary: autoradiographic identification and localization. De Souza, E.B., Kuyatt, B.L. Endocrinology (1987) [Pubmed]
  39. Biochemical characterization of guanidinium chloride-soluble dentine collagen from lathyritic-rat incisors. Wohllebe, M., Carmichael, D.J. Biochem. J. (1979) [Pubmed]
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