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Gene Review:

Ifi47 - interferon gamma inducible protein 47

Rattus norvegicus

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Disease relevance of Ifi47

Production of the chemokines monocyte chemotactic protein-1, regulated on activation normal T cell expressed and secreted protein, growth-related oncogene, and interferon-gamma-inducible protein-10 is induced by the Sendai virus in human and rat testicular cells [1].
Astrocytes from experimental allergic encephalomyelitis (EAE)-susceptible Lewis rats expressed higher levels of Interferon-gamma-inducible Ia than astrocytes from EAE-resistant Brown Norway (BN) rats, whereas BN microglia expressed higher Ia than Lewis at both mRNA and protein levels [2].

High impact information on Ifi47

The authors investigated the expression of the chemoattractants monocyte chemoattractant protein MCP-1, regulation on activation normal T-cell expressed and secreted (RANTES), and interferon-gamma inducible protein IP10 after peripheral nerve lesion of the facial and hypoglossal nuclei [3].
RESULTS: The MC-2 peptide was found to inhibit binding of interferon-gamma, as well as that of the chemokines, interleukin-8, interferon gamma inducible protein-10, and regulated on activation normal T cell expressed and secreted (RANTES), to GAGs in vitro [4].
MCP-1, regulated on activation normal T cell expressed and secreted protein, growth-related oncogene-alpha, and interferon-gamma-inducible protein-10 have been reported to be chemoattractants for a large variety of leukocytes [1].
Expression and regulation of interferon-gamma-inducible protein 10 gene in rat Leydig cells [5].
Of them, interferon-gamma-inducible protein 10 (IP-10), Mx1, and guanylate-binding protein-2 mRNA abundance in infected F344 rats was 201.5, 188.2, and 281.7% higher, respectively, than that of infected BN rats at 2 days after inoculation [6].

Anatomical context of Ifi47

Interferon-gamma-inducible genes in primary glial cells of the central nervous system: comparisons of astrocytes with microglia and Lewis with brown Norway rats [7].
Serological characterization of macrophage hybridomas: identification of an interferon-gamma-inducible surface marker [8].

Other interactions of Ifi47

Interferon-gamma-inducible protein, 10 kDa (IP-10), chemoattractant towards activated T-lymphocytes, was significantly elevated at 6 and 12 hr postinjury [9].

References

Production of the chemokines monocyte chemotactic protein-1, regulated on activation normal T cell expressed and secreted protein, growth-related oncogene, and interferon-gamma-inducible protein-10 is induced by the Sendai virus in human and rat testicular cells. Le Goffic, R., Mouchel, T., Aubry, F., Patard, J.J., Ruffault, A., Jégou, B., Samson, M. Endocrinology (2002) [Pubmed]
Ia expression and antigen presentation by glia: strain and cell type-specific differences among rat astrocytes and microglia. Klyushnenkova, E.N., Vanguri, P. J. Neuroimmunol. (1997) [Pubmed]
Neuronal MCP-1 expression in response to remote nerve injury. Flügel, A., Hager, G., Horvat, A., Spitzer, C., Singer, G.M., Graeber, M.B., Kreutzberg, G.W., Schwaiger, F.W. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
Targeting of glycosaminoglycan-cytokine interactions as a novel therapeutic approach in allotransplantation. Fernandez-Botran, R., Gorantla, V., Sun, X., Ren, X., Perez-Abadia, G., Crespo, F.A., Oliver, R., Orhun, H.I., Quan, E.E., Maldonado, C., Ray, M., Barker, J.H. Transplantation (2002) [Pubmed]
Expression and regulation of interferon-gamma-inducible protein 10 gene in rat Leydig cells. Hu, J., You, S., Li, W., Wang, D., Nagpal, M.L., Mi, Y., Liang, P., Lin, T. Endocrinology (1998) [Pubmed]
Early high expression of IP-10 in F344 rats resistant to Sendai virus-induced airway injury. Cai, X., Castleman, W.L. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
Interferon-gamma-inducible genes in primary glial cells of the central nervous system: comparisons of astrocytes with microglia and Lewis with brown Norway rats. Vanguri, P. J. Neuroimmunol. (1995) [Pubmed]
Serological characterization of macrophage hybridomas: identification of an interferon-gamma-inducible surface marker. Martin, C.A., Willmer, U., Falkenberg, F.W., Dorf, M.E. Cell. Immunol. (1988) [Pubmed]
Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury. McTigue, D.M., Tani, M., Krivacic, K., Chernosky, A., Kelner, G.S., Maciejewski, D., Maki, R., Ransohoff, R.M., Stokes, B.T. J. Neurosci. Res. (1998) [Pubmed]

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IFGGC1	Canis lupus familiaris
Ifi47	Mus musculus

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