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Gene Review

Cxcl10  -  chemokine (C-X-C motif) ligand 10

Rattus norvegicus

Synonyms: 10 kDa interferon gamma-induced protein, C-X-C motif chemokine 10, Gamma-IP10, IP-10, Inp10, ...
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Disease relevance of Cxcl10


High impact information on Cxcl10

  • Northern analysis indicated that mRNAs for mob-1 and another chemokine, mcp-1, were induced after cerulein hyperstimulation in vivo. mob-1 mRNA was also induced by retrograde injection of bile salts and by cerulein in acinar cells in vitro. mob-1 protein was localized to exocrine cells in pancreata of diseased animals [6].
  • Immunopathological and chemokine analysis during the acute phase revealed that there were marked macrophage infiltration with myocyte necrosis and up-regulation of MCP-1 and IFN-gamma-inducible protein-10 (IP-10) [7].
  • IFN-gamma-inducible protein 10 (IP-10) is a CXC chemokine that stimulates the directional migration of activated T cells, particularly Th1 cells [8].
  • Administration of plasmid DNA encoding self IP-10 was found capable of breaking down immunological tolerance to IP-10, resulting in the generation of self-specific immunity to the gene product of the vaccine [8].
  • We show here that during the course of adjuvant-induced arthritis the immune system mounts a notable Ab titer against self-IP-10 [9].

Chemical compound and disease context of Cxcl10


Biological context of Cxcl10

  • Interferon-inducible protein-10 involves vascular smooth muscle cell migration, proliferation, and inflammatory response [11].
  • The effects of CXCL10 were not accompanied by a shift in resting membrane potential (RMP) or input resistance [12].
  • In this paper, four classes of natural product inhibitors (IC50 ranging 0.1-41 microM) have been described that block the CXCR3 receptor interaction of IP-10 ligand [2].
  • The kinetics of GRO/KC and IP-10/mob-1 mRNA expression by peritubular and Sertoli cells (significant stimulation as early as 1 hour and 4 hours post-exposure to the stimuli, respectively) are compatible with the hypothesis of a rapid mobilisation of these cells in an inflammatory process [4].
  • GRO/KC (growth-related oncogene) and IP-10/mob-1 (IFN-gamma-inducible protein) are two CXC-chemokines which attract neutrophils and activated T lymphocytes, respectively, have been studied for their ability to participate to testicular inflammation (orchitis) [4].

Anatomical context of Cxcl10


Associations of Cxcl10 with chemical compounds


Regulatory relationships of Cxcl10

  • These findings suggest that CXCL10 produced in the LN plays a specific inhibitory role in the development of Th1-mediated diseases such as EAE by holding sensitized and activated Th1s expressing CXCR3 in the draining LN [1].

Other interactions of Cxcl10

  • However, we observed that neutralization of IP-10 increased IFN-gamma protein in bronchoalveolar lavage (BAL) fluid of F344 rats 7 days after inoculation compared with rats that received normal rabbit serum [18].
  • Expression of the CXCR3 chemokine receptor supports a direct effect of CXCL10 on hippocampal neurons [12].
  • In this study, we provide evidence for direct modulatory effects of the chemokine, CXCL10, on the physiology of hippocampal neurons maintained in primary culture [12].
  • The culture supernatant of cells transfected with these DNAs inhibited the migration of T cells and macrophages induced by MCP-1 and IP-10 [7].
  • IL-8 and MIP-2 levels in the ischemic hemispheres peaked at 24 h, whereas IP-10 showed a biphasic profile with two peaks at 6 h and 6 days after pMCAO [19].

Analytical, diagnostic and therapeutic context of Cxcl10


  1. Neutralization of IFN-inducible protein 10/CXCL10 exacerbates experimental autoimmune encephalomyelitis. Narumi, S., Kaburaki, T., Yoneyama, H., Iwamura, H., Kobayashi, Y., Matsushima, K. Eur. J. Immunol. (2002) [Pubmed]
  2. Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3. Ondeykal, J.G., Herath, K.B., Jayasuriya, H., Polishook, J.D., Bills, G.F., Dombrowski, A.W., Mojena, M., Koch, G., DiSalvo, J., DeMartino, J., Guan, Z., Nanakorn, W., Morenberg, C.M., Balick, M.J., Stevenson, D.W., Slattery, M., Borris, R.P., Singh, S.B. Mol. Divers. (2005) [Pubmed]
  3. Hypothermia-enhanced splenic cytokine gene expression is independent of the sympathetic nervous system. Ganta, C.K., Helwig, B.G., Blecha, F., Ganta, R.R., Cober, R., Parimi, S., Musch, T.I., Fels, R.J., Kenney, M.J. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]
  4. Expression and regulation of the CXC-chemokines, GRO/KC and IP-10/mob-1 in rat seminiferous tubules. Aubry, F., Habasque, C., Satie, A.P., Jégou, B., Samson, M. Eur. Cytokine Netw. (2000) [Pubmed]
  5. Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity. Biragyn, A., Tani, K., Grimm, M.C., Weeks, S., Kwak, L.W. Nat. Biotechnol. (1999) [Pubmed]
  6. Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis. Grady, T., Liang, P., Ernst, S.A., Logsdon, C.D. Gastroenterology (1997) [Pubmed]
  7. C protein-induced myocarditis and subsequent dilated cardiomyopathy: rescue from death and prevention of dilated cardiomyopathy by chemokine receptor DNA therapy. Matsumoto, Y., Tsukada, Y., Miyakoshi, A., Sakuma, H., Kohyama, K. J. Immunol. (2004) [Pubmed]
  8. Plasmid DNA encoding IFN-gamma-inducible protein 10 redirects antigen-specific T cell polarization and suppresses experimental autoimmune encephalomyelitis. Wildbaum, G., Netzer, N., Karin, N. J. Immunol. (2002) [Pubmed]
  9. Targeting the function of IFN-gamma-inducible protein 10 suppresses ongoing adjuvant arthritis. Salomon, I., Netzer, N., Wildbaum, G., Schif-Zuck, S., Maor, G., Karin, N. J. Immunol. (2002) [Pubmed]
  10. Chronic intrathecal infusion of phosphorothioate or phosphodiester antisense oligonucleotides against cytokine responsive gene-2/IP-10 in experimental allergic encephalomyelitis of lewis rat. Wojcik, W.J., Swoveland, P., Zhang, X., Vanguri, P. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  11. Interferon-inducible protein-10 involves vascular smooth muscle cell migration, proliferation, and inflammatory response. Wang, X., Yue, T.L., Ohlstein, E.H., Sung, C.P., Feuerstein, G.Z. J. Biol. Chem. (1996) [Pubmed]
  12. The chemokine CXCL10 modulates excitatory activity and intracellular calcium signaling in cultured hippocampal neurons. Nelson, T.E., Gruol, D.L. J. Neuroimmunol. (2004) [Pubmed]
  13. Early up-regulation of CXC-chemokine expression is associated with strong cellular immune responses to murine skin xenografts. Lee, E.M., Park, J.O., Kim, D., Kim, J.Y., Oh, K.H., Park, C.G., Oh, B.H., Kim, S., Ahn, C. Xenotransplantation (2006) [Pubmed]
  14. Differential display identifies neuroendocrine-specific protein-A (NSP-A) and interferon-inducible protein 10 (IP-10) as ethanol-responsive genes in the fetal rat brain. Yang, J., Zoeller, R.T. Brain Res. Dev. Brain Res. (2002) [Pubmed]
  15. Prolonged expression of interferon-inducible protein-10 in ischemic cortex after permanent occlusion of the middle cerebral artery in rat. Wang, X., Ellison, J.A., Siren, A.L., Lysko, P.G., Yue, T.L., Barone, F.C., Shatzman, A., Feuerstein, G.Z. J. Neurochem. (1998) [Pubmed]
  16. Atorvastatin reduces NF-kappaB activation and chemokine expression in vascular smooth muscle cells and mononuclear cells. Ortego, M., Bustos, C., Hernández-Presa, M.A., Tuñón, J., Díaz, C., Hernández, G., Egido, J. Atherosclerosis (1999) [Pubmed]
  17. Morphine physical dependence intensification by hypoglycemia: NMDA receptor involvement. Koyuncuoğlu, H., Hatipoğlu, I., Sarica, O. Pharmacol. Biochem. Behav. (1994) [Pubmed]
  18. Increased IFN-gamma protein in bronchoalveolar lavage fluid of anti-IP-10 antibody-treated F344 rats following Sendai viral infection. Cai, X., Castleman, W.L. J. Interferon Cytokine Res. (2002) [Pubmed]
  19. IL-17 and IFN-gamma mRNA expression is increased in the brain and systemically after permanent middle cerebral artery occlusion in the rat. Li, H.L., Kostulas, N., Huang, Y.M., Xiao, B.G., van der Meide, P., Kostulas, V., Giedraitas, V., Link, H. J. Neuroimmunol. (2001) [Pubmed]
  20. IFN-inducible protein-10 has a differential role in podocyte during Thy 1.1 glomerulonephritis. Han, G.D., Koike, H., Nakatsue, T., Suzuki, K., Yoneyama, H., Narumi, S., Kobayashi, N., Mundel, P., Shimizu, F., Kawachi, H. J. Am. Soc. Nephrol. (2003) [Pubmed]
  21. Changes of inducible protein-10 and regulated upon activation, normal T cell expressed and secreted protein in acute rejection of pancreas transplantation in rats. Zhu, J., Xu, Z.K., Miao, Y., Liu, X.L., Zhang, H. World J. Gastroenterol. (2006) [Pubmed]
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