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Gene Review

Prkg2  -  protein kinase, cGMP-dependent, type II

Rattus norvegicus

Synonyms: GDPKII, cGK 2, cGK2, cGKII, cGMP-dependent protein kinase 2, ...
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Disease relevance of Prkg2


High impact information on Prkg2


Biological context of Prkg2


Anatomical context of Prkg2

  • One important class of target molecules for cGMP is cGMP-dependent protein kinases, and in the present study, biochemical and immunocytochemical analyses demonstrate the widespread distribution of type II cGMP-dependent protein kinase in rat brain, from the cerebral cortex to the brainstem and cerebellum [6].

Associations of Prkg2 with chemical compounds

  • The slow activation by cGKII could not be ascribed to counteracting protein phosphatases, since neither calyculin A, a potent inhibitor of phosphatase 1 and 2A, nor ATP gamma S (adenosine 5'-O-(thiotriphosphate)), producing stable thiophosphorylation, was able to enhance the activation kinetics [3].

Analytical, diagnostic and therapeutic context of Prkg2

  • The expression of neuronal nitric oxide synthase (nNOS) and the cGMP-dependent protein kinases cGKI and cGKII in rat cerebellum was evaluated at different developmental stages by quantitative RT-PCR and Western blotting. mRNAs coding for these proteins were detected in the cerebella of rats aged 7, 14 and 21 days [7].
  • A PCR product with the size predicted from the type II cGMP-dependent protein kinase (cGK II) cDNA was detected in various regions of the brain, with highest expression in the thalamus [8].


  1. Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression. Gambaryan, S., Häusler, C., Markert, T., Pöhler, D., Jarchau, T., Walter, U., Haase, W., Kurtz, A., Lohmann, S.M. J. Clin. Invest. (1996) [Pubmed]
  2. Endogenous type II cGMP-dependent protein kinase exists as a dimer in membranes and can Be functionally distinguished from the type I isoforms. Vaandrager, A.B., Edixhoven, M., Bot, A.G., Kroos, M.A., Jarchau, T., Lohmann, S., Genieser, H.G., de Jonge, H.R. J. Biol. Chem. (1997) [Pubmed]
  3. Isotype-specific activation of cystic fibrosis transmembrane conductance regulator-chloride channels by cGMP-dependent protein kinase II. French, P.J., Bijman, J., Edixhoven, M., Vaandrager, A.B., Scholte, B.J., Lohmann, S.M., Nairn, A.C., de Jonge, H.R. J. Biol. Chem. (1995) [Pubmed]
  4. Nitric oxide regulates cyclic GMP-dependent protein kinase phosphorylation in rat brain. El-Husseini, A.E., Bladen, C., Williams, J.A., Reiner, P.B., Vincent, S.R. J. Neurochem. (1998) [Pubmed]
  5. Colonocyte basolateral membranes contain Escherichia coli heat-stable enterotoxin receptors. Albano, F., Brasitus, T., Mann, E.A., Guarino, A., Giannella, R.A. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  6. Localization of cGMP-dependent protein kinase type II in rat brain. de Vente, J., Asan, E., Gambaryan, S., Markerink-van Ittersum, M., Axer, H., Gallatz, K., Lohmann, S.M., Palkovits, M. Neuroscience (2001) [Pubmed]
  7. Expression of cGMP-dependent protein kinases (I and II) and neuronal nitric oxide synthase in the developing rat cerebellum. Jurado, S., Sánchez-Prieto, J., Torres, M. Brain Res. Bull. (2005) [Pubmed]
  8. Molecular characterization of a type II cyclic GMP-dependent protein kinase expressed in the rat brain. el-Husseini, A.E., Bladen, C., Vincent, S.R. J. Neurochem. (1995) [Pubmed]
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