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Gene Review

PRKG2  -  protein kinase, cGMP-dependent, type II

Homo sapiens

Synonyms: PRKGR2, cGK 2, cGK2, cGKII, cGMP-dependent protein kinase 2, ...
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Disease relevance of PRKG2

  • Because cGKII mediates the effects of heat-stable enterotoxins via the cystic fibrosis transmembrane regulator Cl(-) channel, these findings define a structural target for drug design [1].
  • Herein, we review the molecular mechanism of regulation of chondrocyte hypertrophy by cGKII and the interaction between cGKII and other signaling pathways [2].

High impact information on PRKG2


Biological context of PRKG2


Anatomical context of PRKG2


Associations of PRKG2 with chemical compounds

  • To examine the effect of this interaction on ligand binding and kinase activation in the type II isozyme of cGMP-dependent protein kinase (cGKII), alanine was substituted for the conserved threonine or serine. cGKII was found to require the C2 amino group of cGMP and its cognate serine or threonine hydroxyl for efficient cGMP activation [1].

Other interactions of PRKG2

  • Based on sequence information from this complementary DNA, the 5'-end of the type II cGMP-dependent protein kinase was amplified from human brain messenger RNA using polymerase chain reaction [8].
  • A total of four different nitrated peptides were characterized and were matched to four different proteins: synaptosomal-associated protein, actin, immunoglobulin alpha Fc receptor, and cGMP-dependent protein kinase 2 [13].
  • Finally, we present evidence that the dominant negative properties of this truncation mutant are specific to cGKII when compared with cAMP-dependent protein kinase Calpha and cGKIbeta [9].
  • These results suggest that Ser(19) of human PTPS may be a substrate for cGKII phosphorylation also in vivo, a modification that is essential for normal activity [10].

Analytical, diagnostic and therapeutic context of PRKG2


  1. The amino-terminal cyclic nucleotide binding site of the type II cGMP-dependent protein kinase is essential for full cyclic nucleotide-dependent activation. Taylor, M.K., Uhler, M.D. J. Biol. Chem. (2000) [Pubmed]
  2. Involvement of cyclic guanosine monophosphate-dependent protein kinase II in chondrocyte hypertrophy during endochondral ossification. Kugimiya, F., Chikuda, H., Kamekura, S., Ikeda, T., Hoshi, K., Ogasawara, T., Nakamura, K., Chung, U.I., Kawaguchi, H. Modern rheumatology / the Japan Rheumatism Association. (2005) [Pubmed]
  3. Function of cGMP-dependent protein kinases as revealed by gene deletion. Hofmann, F., Feil, R., Kleppisch, T., Schlossmann, J. Physiol. Rev. (2006) [Pubmed]
  4. Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator. Markert, T., Vaandrager, A.B., Gambaryan, S., Pöhler, D., Häusler, C., Walter, U., De Jonge, H.R., Jarchau, T., Lohmann, S.M. J. Clin. Invest. (1995) [Pubmed]
  5. Guanylin regulates chloride secretion in the human gallbladder via the bile fluid. Kulaksiz, H., Schlenker, T., Rost, D., Stiehl, A., Volkmann, M., Lehnert, T., Cetin, Y., Stremmel, W. Gastroenterology (2004) [Pubmed]
  6. cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein. Cha, B., Kim, J.H., Hut, H., Hogema, B.M., Nadarja, J., Zizak, M., Cavet, M., Lee-Kwon, W., Lohmann, S.M., Smolenski, A., Tse, C.M., Yun, C., de Jonge, H.R., Donowitz, M. J. Biol. Chem. (2005) [Pubmed]
  7. Characterization of the gene encoding the human type II cGMP-dependent protein kinase. Witczak, O., Orstavik, S., Natarajan, V., Frengen, E., Jahnsen, T., Sandberg, M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  8. Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase. Orstavik, S., Solberg, R., Taskén, K., Nordahl, M., Altherr, M.R., Hansson, V., Jahnsen, T., Sandberg, M. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  9. Autoinhibition and isoform-specific dominant negative inhibition of the type II cGMP-dependent protein kinase. Taylor, M.K., Ahmed, R., Begley, M., Uhler, M.D. J. Biol. Chem. (2002) [Pubmed]
  10. Serine 19 of human 6-pyruvoyltetrahydropterin synthase is phosphorylated by cGMP protein kinase II. Scherer-Oppliger, T., Leimbacher, W., Blau, N., Thöny, B. J. Biol. Chem. (1999) [Pubmed]
  11. The ascending reticular activating system--from aminergic neurons to nitric oxide. Vincent, S.R. J. Chem. Neuroanat. (2000) [Pubmed]
  12. Genome-wide cDNA microarray screening to correlate gene expression profile with survival in patients with advanced lung cancer. Ikehara, M., Oshita, F., Sekiyama, A., Hamanaka, N., Saito, H., Yamada, K., Noda, K., Kameda, Y., Miyagi, Y. Oncol. Rep. (2004) [Pubmed]
  13. The human pituitary nitroproteome: detection of nitrotyrosyl-proteins with two-dimensional Western blotting, and amino acid sequence determination with mass spectrometry. Zhan, X., Desiderio, D.M. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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