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DAZAP1  -  DAZ associated protein 1

Homo sapiens

Synonyms: DAZ-associated protein 1, Deleted in azoospermia-associated protein 1, MGC19907
 
 
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Disease relevance of DAZAP1

  • Deleted in Azoospermia Associated Protein 1 (DAZAP1) is a ubiquitous RNA-binding protein highly expressed in the human and the mouse testes [1].
  • Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL [2].
  • BACKGROUND: DAZAP1 (DAZ Associated Protein 1) was originally identified by a yeast two-hybrid system through its interaction with a putative male infertility factor, DAZ (Deleted in Azoospermia) [2].
 

High impact information on DAZAP1

 

Biological context of DAZAP1

  • In mammalian species, DAZAP1 may be involved in diverse reproductive functions, ranging from cell cycle regulation and maturation of oocytes to differentiation of luteal cells [4].
  • The DAZAP genes were mapped to chromosomal regions 19p13.3 and 2q33-q34, respectively, where no genetic diseases affecting spermatogenesis are known to map [5].
  • The mutation of Thr(269) and Thr(315) to aspartate or the phosphorylation of these residues caused DAZAP1 to dissociate from its binding partner DAZ [6].
 

Anatomical context of DAZAP1

 

Associations of DAZAP1 with chemical compounds

  • A protein in RAW 264.7 macrophages, which became phosphorylated in response to LPS (lipopolysaccharide), was identified as the RNA-binding protein called DAZAP1 [DAZ (deleted in azoospermia)-associated protein 1] [6].
 

Physical interactions of DAZAP1

  • DAZAP1 contains two RNA-binding domains (RBDs) and a proline-rich C-terminal portion, and is expressed most abundantly in the testis [2].
 

Other interactions of DAZAP1

  • DAZAP1 encodes a novel RNA-binding protein that is expressed most abundantly in the testis, and DAZAP2 encodes a ubiquitously expressed protein with no recognizable functional motif [5].
  • CONCLUSION(S): The expression patterns of DAZAP1 and DAZL are identical within rat and human ovaries [4].
 

Analytical, diagnostic and therapeutic context of DAZAP1

References

  1. A novel nucleocytoplasmic shuttling sequence of DAZAP1, a testis-abundant RNA-binding protein. Lin, Y.T., Yen, P.H. RNA (2006) [Pubmed]
  2. Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL. Dai, T., Vera, Y., Salido, E.C., Yen, P.H. BMC Genomics (2001) [Pubmed]
  3. Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia. Prima, V., Gore, L., Caires, A., Boomer, T., Yoshinari, M., Imaizumi, M., Varella-Garcia, M., Hunger, S.P. Leukemia (2005) [Pubmed]
  4. Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries. Pan, H.A., Lin, Y.S., Lee, K.H., Huang, J.R., Lin, Y.H., Kuo, P.L. Fertil. Steril. (2005) [Pubmed]
  5. Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1. Tsui, S., Dai, T., Roettger, S., Schempp, W., Salido, E.C., Yen, P.H. Genomics (2000) [Pubmed]
  6. Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ. Morton, S., Yang, H.T., Moleleki, N., Campbell, D.G., Cohen, P., Rousseau, S. Biochem. J. (2006) [Pubmed]
  7. Identification of a novel fusion gene in a pre-B acute lymphoblastic leukemia with t(1;19)(q23;p13). Yuki, Y., Imoto, I., Imaizumi, M., Hibi, S., Kaneko, Y., Amagasa, T., Inazawa, J. Cancer Sci. (2004) [Pubmed]
  8. Deleted in azoospermia associated protein 1 shuttles between nucleus and cytoplasm during normal germ cell maturation. Vera, Y., Dai, T., Hikim, A.P., Lue, Y., Salido, E.C., Swerdloff, R.S., Yen, P.H. J. Androl. (2002) [Pubmed]
 
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