Gene Review:
PAK3 - p21 protein (Cdc42/Rac)-activated kinase 3
Homo sapiens
Synonyms:
Beta-PAK, CDKN1A, MRX30, MRX47, OPHN3, ...
- "UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infection. Nguyen, D.G., Wolff, K.C., Yin, H., Caldwell, J.S., Kuhen, K.L. J. Virol. (2006)
- The RhoGAP activity of OPHN1, a new F-actin-binding protein, is negatively controlled by its amino-terminal domain. Fauchereau, F., Herbrand, U., Chafey, P., Eberth, A., Koulakoff, A., Vinet, M.C., Ahmadian, M.R., Chelly, J., Billuart, P. Mol. Cell. Neurosci. (2003)
- Independent activation of endogenous p21-activated protein kinase-3 (PAK3) and JNK by thrombin in CCL39 fibroblasts. Malcolm, K.C., Chambard, J.C., Grall, D., Pouysségur, J., van Obberghen-Schilling, E. J. Cell. Physiol. (2000)
- Missense mutation in PAK3, R67C, causes X-linked nonspecific mental retardation. Bienvenu, T., des Portes, V., McDonell, N., Carrié, A., Zemni, R., Couvert, P., Ropers, H.H., Moraine, C., van Bokhoven, H., Fryns, J.P., Allen, K., Walsh, C.A., Boué, J., Kahn, A., Chelly, J., Beldjord, C. Am. J. Med. Genet. (2000)
- The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. King, A.J., Sun, H., Diaz, B., Barnard, D., Miao, W., Bagrodia, S., Marshall, M.S. Nature (1998)
- S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3. Chiloeches, A., Mason, C.S., Marais, R. Mol. Cell. Biol. (2001)
- Interaction of paxillin with p21-activated Kinase (PAK). Association of paxillin alpha with the kinase-inactive and the Cdc42-activated forms of PAK3. Hashimoto, S., Tsubouchi, A., Mazaki, Y., Sabe, H. J. Biol. Chem. (2001)
- AILIM/ICOS-mediated elongation of activated T cells is regulated by both the PI3-kinase/Akt and Rho family cascade. Nukada, Y., Okamoto, N., Konakahara, S., Tezuka, K., Ohashi, K., Mizuno, K., Tsuji, T. Int. Immunol. (2006)
- Sequential implication of the mental retardation proteins ARHGEF6 and PAK3 in spine morphogenesis. Nod??-Langlois, R., Muller, D., Boda, B. J. Cell. Sci. (2006)
- A novel regulator of p21-activated kinases. Bagrodia, S., Taylor, S.J., Jordon, K.A., Van Aelst, L., Cerione, R.A. J. Biol. Chem. (1998)
- The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus. Boda, B., Alberi, S., Nikonenko, I., Node-Langlois, R., Jourdain, P., Moosmayer, M., Parisi-Jourdain, L., Muller, D. J. Neurosci. (2004)
- Identification and characterization of HLA-class-I-restricted T-cell epitopes in the putative tumor-associated antigens P21-activated serin kinase 2 (PAK2) and cyclin-dependent kinase inhibitor 1A (CDKN1A). Li, G., Hundemer, M., Wolfrum, S., Ho, A.D., Goldschmidt, H., Witzens-Harig, M. Ann. Hematol. (2006)
- Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak. Sun, H., King, A.J., Diaz, H.B., Marshall, M.S. Curr. Biol. (2000)
- Up-regulation of p21- and RhoA-activated protein kinases in human pregnant myometrium. Moore, F., Da Silva, C., Wilde, J.I., Smarason, A., Watson, S.P., López Bernal, A. Biochem. Biophys. Res. Commun. (2000)
- X-linked mild non-syndromic mental retardation with neuropsychiatric problems and the missense mutation A365E in PAK3. Gedeon, A.K., Nelson, J., Gécz, J., Mulley, J.C. Am. J. Med. Genet. A (2003)
- Regional localisation of two non-specific X-linked mental retardation genes (MRX30 and MRX31). Donnelly, A.J., Partington, M.W., Ryan, A.K., Mulley, J.C. Am. J. Med. Genet. (1996)
- A YAC contig in Xq22.3-q23, from DXS287 to DXS8088, spanning the brain-specific genes doublecortin (DCX) and PAK3. Allen, K.M., Gleeson, J.G., Shoup, S.M., Walsh, C.A. Genomics (1998)