Gene Review:
GLUD2 - glutamate dehydrogenase 2
Homo sapiens
Synonyms:
GDH 2, GDH2, GLUDP1, Glutamate dehydrogenase 2, mitochondrial
- SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic beta Cells. Haigis, M.C., Mostoslavsky, R., Haigis, K.M., Fahie, K., Christodoulou, D.C., Murphy, A.J., Valenzuela, D.M., Yancopoulos, G.D., Karow, M., Blander, G., Wolberger, C., Prolla, T.A., Weindruch, R., Alt, F.W., Guarente, L. Cell (2006)
- Masking by enzyme inhibitor of raised serum glutamate dehydrogenase activity in Reye's syndrome. Holt, J.T., Arvan, D.A., Mayer, T.K. Lancet (1983)
- Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice. Li, C., Matter, A., Kelly, A., Petty, T.J., Najafi, H., MacMullen, C., Daikhin, Y., Nissim, I., Lazarow, A., Kwagh, J., Collins, H.W., Hsu, B.Y., Nissim, I., Yudkoff, M., Matschinsky, F.M., Stanley, C.A. J. Biol. Chem. (2006)
- Structural consequences of sequence patterns in the fingerprint region of the nucleotide binding fold. Implications for nucleotide specificity. Baker, P.J., Britton, K.L., Rice, D.W., Rob, A., Stillman, T.J. J. Mol. Biol. (1992)
- Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism. Hoe, F.M., Thornton, P.S., Wanner, L.A., Steinkrauss, L., Simmons, R.A., Stanley, C.A. J. Pediatr. (2006)
- Glutamate dehydrogenase deficiency in three patients with spinocerebellar syndrome. Plaitakis, A., Nicklas, W.J., Desnick, R.J. Ann. Neurol. (1980)
- Glutamate metabolism of leukocytes and skin fibroblasts in spinocerebellar degeneration with lowered glutamate dehydrogenase activity. Tatsumi, C., Yorifuji, S., Kajiyama, K., Ueno, S., Takahashi, M., Tarui, S. Acta neurologica Scandinavica. (1989)
- Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase. Kanavouras, K., Mastorodemos, V., Borompokas, N., Spanaki, C., Plaitakis, A. J. Neurosci. Res. (2007)
- Assignment of the GDH loci to human chromosomes 10q23 and Xq24 by in situ hybridization. Jung, K.Y., Warter, S., Rumpler, Y. Ann. Genet. (1989)
- Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme. Plaitakis, A., Spanaki, C., Mastorodemos, V., Zaganas, I. Neurochem. Int. (2003)
- Differential glutamate dehydrogenase (GDH) activity profile in patients with temporal lobe epilepsy. Malthankar-Phatak, G.H., de Lanerolle, N., Eid, T., Spencer, D.D., Behar, K.L., Spencer, S.S., Kim, J.H., Lai, J.C. Epilepsia (2006)
- Lymphocyte glutamate dehydrogenase activity in normal aging and neurological diseases. Iwatsuji, K., Nakamura, S., Kameyama, M. Gerontology. (1989)
- The effect of nucleotides on glutamate dehydrogenase from the mealworm fat body. Teller, J.K. Arch. Int. Physiol. Biochim. (1987)
- Molecular basis of human glutamate dehydrogenase regulation under changing energy demands. Mastorodemos, V., Zaganas, I., Spanaki, C., Bessa, M., Plaitakis, A. J. Neurosci. Res. (2005)
- Evaluation of two X chromosomal candidate genes for Rett syndrome: glutamate dehydrogenase-2 (GLUD2) and rab GDP-dissociation inhibitor (GDI1). Wan, M., Francke, U. Am. J. Med. Genet. (1998)
- Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function. Plaitakis, A., Metaxari, M., Shashidharan, P. J. Neurochem. (2000)
- Regulation of glutamate dehydrogenase by reversible ADP-ribosylation in mitochondria. Herrero-Yraola, A., Bakhit, S.M., Franke, P., Weise, C., Schweiger, M., Jorcke, D., Ziegler, M. EMBO J. (2001)
- Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme. Zaganas, I., Plaitakis, A. J. Biol. Chem. (2002)
- Performance of the TechLab C. DIFF CHEK-60 enzyme immunoassay (EIA) in combination with the C. difficile Tox A/B II EIA kit, the Triage C. difficile panel immunoassay, and a cytotoxin assay for diagnosis of Clostridium difficile-associated diarrhea. Snell, H., Ramos, M., Longo, S., John, M., Hussain, Z. J. Clin. Microbiol. (2004)
- Normal cerebellar glutamate dehydrogenase protein in spinocerebellar degeneration. Rosenberg, R.N., Banner, C. J. Neurol. Neurosurg. Psychiatr. (1989)
- Formation and characterization of glutamate dehydrogenase monolayers on silicon supports. Blasi, L., Longo, L., Pompa, P.P., Manna, L., Ciccarella, G., Vasapollo, G., Cingolani, R., Rinaldi, R., Rizzello, A., Acierno, R., Storelli, C., Maffia, M. Biosensors & bioelectronics. (2005)
- A two-dimensional imaging biosensor to monitor enhanced brain glutamate release stimulated by nicotine. Qhobosheane, M., Wu, D., Gu, Y., Tan, W. J. Neurosci. Methods (2004)