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UL35  -  located externally on capsid hexons

Human herpesvirus 1

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Disease relevance of UL35

  • The UL35 (VP26) gene was not required for assembly of 100-nm capsids, although assembly of B capsids was more efficient when it was present [1].
  • The capsid of herpes simplex virus type 1 (HSV-1) is composed of seven proteins, VP5, VP19C, VP21, VP22a, VP23, VP24, and VP26, which are the products of six HSV-1 genes [1].
  • Assembly of herpes simplex virus (HSV) intermediate capsids in insect cells infected with recombinant baculoviruses expressing HSV capsid proteins [1].
  • Eclipse phase of herpes simplex virus type 1 infection: Efficient dynein-mediated capsid transport without the small capsid protein VP26 [2].
  • Despite the discovery of Epstein-Barr virus more than 35 years ago, a thorough understanding of gammaherpesvirus capsid composition and structure has remained elusive [3].

High impact information on UL35


Chemical compound and disease context of UL35

  • The protein kinase associated with purified herpes simplex virus 1 and 2 virions partitioned with the capsid-tegument structures and was not solubilized by non-ionic detergents and low, non-inhibitory concentrations of urea [8].
  • An 87 bp DNA fragment from the vp72 capsid protein gene of African Swine Fever virus (ASFV) and the entire Leishmania major glycoprotein gp63 gene were expressed in this system [9].

Biological context of UL35

  • Epstein-Barr virus (EBV), a possible cause of Kawasaki syndrome (KS), is not pathenogenically associated with KS in Hawaii. The prevalence of EBV capsid antibody in KS patients was found not to differ significantly from that in controls, and the antibody response in those infected with EBV was the same as that in other children similarly infected [10].
  • Depending on the size of the capsid enclosing the genome, three principles of viral nucleic acids import are discussed [11].
  • In addition, retargeting of the viral tropism towards tumours by capsid modifications has been examined [12].

Anatomical context of UL35

  • The first principle is that the capsid disassembles in the cytosol or in a docked state at the nuclear pore complex and a subviral genomic complex is trafficked through the pore [11].

Analytical, diagnostic and therapeutic context of UL35


  1. Assembly of herpes simplex virus (HSV) intermediate capsids in insect cells infected with recombinant baculoviruses expressing HSV capsid proteins. Thomsen, D.R., Roof, L.L., Homa, F.L. J. Virol. (1994) [Pubmed]
  2. Eclipse phase of herpes simplex virus type 1 infection: Efficient dynein-mediated capsid transport without the small capsid protein VP26. Döhner, K., Radtke, K., Schmidt, S., Sodeik, B. J. Virol. (2006) [Pubmed]
  3. Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirus. Nealon, K., Newcomb, W.W., Pray, T.R., Craik, C.S., Brown, J.C., Kedes, D.H. J. Virol. (2001) [Pubmed]
  4. Elevated immunofluorescence antibody titers to several herpesviruses in Burkitt's lymphoma patients: are high titers unique? Hilgers, F., Dean, A.G., de-Thé, G. J. Natl. Cancer Inst. (1975) [Pubmed]
  5. Structure of the herpesvirus major capsid protein. Bowman, B.R., Baker, M.L., Rixon, F.J., Chiu, W., Quiocho, F.A. EMBO J. (2003) [Pubmed]
  6. Incorporation of the green fluorescent protein into the herpes simplex virus type 1 capsid. Desai, P., Person, S. J. Virol. (1998) [Pubmed]
  7. Virus-specific interaction between the human cytomegalovirus major capsid protein and the C terminus of the assembly protein precursor. Beaudet-Miller, M., Zhang, R., Durkin, J., Gibson, W., Kwong, A.D., Hong, Z. J. Virol. (1996) [Pubmed]
  8. Herpes simplex virus phosphoproteins. II. Characterization of the virion protein kinase and of the polypeptides phosphorylated in the virion. Lemaster, S., Roizman, B. J. Virol. (1980) [Pubmed]
  9. Development of new cloning vectors for the production of immunogenic outer membrane fusion proteins in Escherichia coli. Cornelis, P., Sierra, J.C., Lim, A., Malur, A., Tungpradabkul, S., Tazka, H., Leitão, A., Martins, C.V., di Perna, C., Brys, L., De Baetseller, P., Hamers, R. Biotechnology (N.Y.) (1996) [Pubmed]
  10. Epstein-Barr virus and other herpesvirus infections in Kawasaki syndrome. Marchette, N.J., Melish, M.E., Hicks, R., Kihara, S., Sam, E., Ching, D. J. Infect. Dis. (1990) [Pubmed]
  11. Nuclear import of viral DNA genomes. Greber, U.F., Fassati, A. Traffic (2003) [Pubmed]
  12. Oncolytic viruses as therapeutic agents. Wildner, O. Ann. Med. (2001) [Pubmed]
  13. Physical mapping and nucleotide sequence of a herpes simplex virus type 1 gene required for capsid assembly. Pertuiset, B., Boccara, M., Cebrian, J., Berthelot, N., Chousterman, S., Puvion-Dutilleul, F., Sisman, J., Sheldrick, P. J. Virol. (1989) [Pubmed]
  14. Reconstitution of herpes simplex virus type 1 nuclear capsid egress in vitro. Rémillard-Labrosse, G., Guay, G., Lippé, R. J. Virol. (2006) [Pubmed]
  15. Studies on the presence of antibodies to EB virus and other herpesviruses in normal children and in infectious mononucleosis. Gergely, L., Czeglédy, J., Váczi, L., Szabó, B., Binder, L., Szalka, A. Acta microbiologica Academiae Scientiarum Hungaricae. (1975) [Pubmed]
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