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Gene Review

Rab5a  -  RAB5A, member RAS oncogene family

Mus musculus

Synonyms: 2410015H04Rik, AI663973, AU021172, Ras-related protein Rab-5A, nnyRab5a
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Disease relevance of Rab5a

  • Here, we report in a pathogenic model of L. monocytogenes (hemolysin-positive strain) that Rab5a plays a central role in Listeria destruction induced by interferon-gamma and within the phagosomal environment [1].

High impact information on Rab5a


Biological context of Rab5a

  • Genetic mapping of the Rab5a and Rab5b genes on mouse Chromosomes 17 and 2, respectively [5].
  • Using retroviral expression of Rab5a:S34N, a dominant negative mutant, and siRNA Rab5a silencing, we demonstrate that Rab5a is essential for the large endosome phenotype and for localization of MR in these structures [6].

Anatomical context of Rab5a


Regulatory relationships of Rab5a


Other interactions of Rab5a


Analytical, diagnostic and therapeutic context of Rab5a


  1. Interferon-gamma listericidal action is mediated by novel Rab5a functions at the phagosomal environment. Prada-Delgado, A., Carrasco-Marin, E., Bokoch, G.M., Alvarez-Dominguez, C. J. Biol. Chem. (2001) [Pubmed]
  2. Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a. Barbieri, M.A., Roberts, R.L., Gumusboga, A., Highfield, H., Alvarez-Dominguez, C., Wells, A., Stahl, P.D. J. Cell Biol. (2000) [Pubmed]
  3. Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules. Christensen, E.I., Devuyst, O., Dom, G., Nielsen, R., Van der Smissen, P., Verroust, P., Leruth, M., Guggino, W.B., Courtoy, P.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. Rab5a is a common component of the apical and basolateral endocytic machinery in polarized epithelial cells. Bucci, C., Wandinger-Ness, A., Lütcke, A., Chiariello, M., Bruni, C.B., Zerial, M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  5. Genetic mapping of the Rab5a and Rab5b genes on mouse Chromosomes 17 and 2, respectively. Barbosa, M.D., Wakeland, E.K., Zerial, M., Kingsmore, S.F. Mamm. Genome (1996) [Pubmed]
  6. IL4/PGE2 induction of an enlarged early endosomal compartment in mouse macrophages is Rab5-dependent. Wainszelbaum, M.J., Proctor, B.M., Pontow, S.E., Stahl, P.D., Barbieri, M.A. Exp. Cell Res. (2006) [Pubmed]
  7. Interferon-gamma selectively induces Rab5a synthesis and processing in mononuclear cells. Alvarez-Dominguez, C., Stahl, P.D. J. Biol. Chem. (1998) [Pubmed]
  8. Colocalization of Fc gamma RI-targeted antigen with class I MHC: implications for antigen processing. Guyre, C.A., Barreda, M.E., Swink, S.L., Fanger, M.W. J. Immunol. (2001) [Pubmed]
  9. Multiple regions contribute to membrane targeting of Rab GTPases. Ali, B.R., Wasmeier, C., Lamoreux, L., Strom, M., Seabra, M.C. J. Cell. Sci. (2004) [Pubmed]
  10. Cytolysin-dependent delay of vacuole maturation in macrophages infected with Listeria monocytogenes. Henry, R., Shaughnessy, L., Loessner, M.J., Alberti-Segui, C., Higgins, D.E., Swanson, J.A. Cell. Microbiol. (2006) [Pubmed]
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