The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SLC2A1  -  solute carrier family 2 (facilitated...

Gallus gallus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SLC2A1

  • We used this system in a functional cDNA screening to isolate and confirm that the glucose transporter protein 1 (GLUT-1) is a receptor for HTLV-1 [1].
  • Neurons were identified by the presence of polysialogangliosides recognized by tetanus toxin (GD1b, GT1) or by the monoclonal antibody Q211 directed against polysialogangliosides containing four, five and six sialic acid residues [2].
  • In acute hypoglycemia, induced by a single dose of tolbutamide (100 mg/kg body mass), HKII, PFK-1 and GS mRNA levels remained unchanged; however, levels of HKI mRNA and glucose transporter 1 (GLUT1) were significantly increased 4 h after administration [3].
  • We investigated the effects on the avian ALAS-1 gene promoter of a phenobarbital-like chemical, Glut (glutethimide), and a haem synthesis inhibitor, DHA (4,6-dioxoheptanoic acid), using a reporter gene assay in transiently transfected LMH (Leghorn male hepatoma) hepatoma cells [4].

High impact information on SLC2A1

  • Cloning and sequencing of chicken GLUT1 cDNA showed that it shares 95% amino acid sequence similarity to mammalian GLUT1s [5].
  • Nevertheless, unlike mammalian GLUT1 mRNA, it was not induced by v-src, serum addition, or treatment with the tumor promoter 12-O-tetradecanoylphorbol 13-acetate in chicken embryo fibroblasts [5].
  • Overexpression of GLUT1 increased 3-O-methylglucose uptake, but did not alter either glucose utilization or glucose-stimulated insulin secretion [6].
  • In embryonic skeletal muscle, the levels of Glut1 and Glut3 proteins and mRNA were highest very early, and declined severely by mid-development [7].
  • The inhibitory effect of a constant amount of GT1 ganglioside was higher at low concentrations of membrane preparation, but the inhibition was similar at different concentrations of the substrates GM3 or UDP-N-acetylgalactosamine and at all incubation times studied [8].

Biological context of SLC2A1


Anatomical context of SLC2A1

  • Compared to the rat control, GLUT1 immunostaining of sparrow extensor digitorum communis muscle was weak and appeared to be localized to blood vessels whereas immunostaining of gastrocnemius muscles was comparable to rat muscle controls [9].
  • GLUT-1 is a ubiquitously expressed plasma membrane glycoprotein with 12 transmembrane domains and 6 extracellular loops (ECL) [1].
  • Even after treatment with anti-inflammatory agents, however, astrocyte graft vasculature fails to express high levels of a barrier marker, the GLUT-1 isoform of the glucose transporter [11].
  • Transplantation of avascular embryonic spinal cord, that induces robust vessel ingrowth and GLUT-1 expression in intra-embryonic vessels, was unable to elicit the ingrowth of more than a few vessels from the chorioallantoic membrane vasculature, and none of these expressed glucose transporter [11].
  • Commitment to the erythrocyte lineage alters expression of specific genes: TFR mRNA level increases while expression decreases for GLUT1 and GLUT3 glucose transporter mRNAs and GAD mRNA [12].

Associations of SLC2A1 with chemical compounds

  • In our analysis of glucose transporter (GLUT) isoform expression, the level of GLUT1 mRNA increased with follicle development while GLUT2, GLUT3 and GLUT8 mRNA levels were unaffected by follicle development [13].
  • The overall increase in GLUT-1 may reflect a deregulation of the transporter induced by ethanol exposure [14].

Analytical, diagnostic and therapeutic context of SLC2A1


  1. Infection of CD4+ T lymphocytes by the human T cell leukemia virus type 1 is mediated by the glucose transporter GLUT-1: evidence using antibodies specific to the receptor's large extracellular domain. Jin, Q., Agrawal, L., VanHorn-Ali, Z., Alkhatib, G. Virology (2006) [Pubmed]
  2. Progenitor cells from embryonic chick dorsal root ganglia differentiate in vitro to neurons: biochemical and electrophysiological evidence. Rohrer, H., Henke-Fahle, S., el-Sharkawy, T., Lux, H.D., Thoenen, H. EMBO J. (1985) [Pubmed]
  3. Changes in muscle mRNAs for hexokinase, phosphofructokinase-1 and glycogen synthase in acute and persistent hypoglycemia induced by tolbutamide in chickens. Seki, Y., Sato, K., Akiba, Y. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2005) [Pubmed]
  4. Haem repression of the housekeeping 5-aminolaevulinic acid synthase gene in the hepatoma cell line LMH. Kolluri, S., Sadlon, T.J., May, B.K., Bonkovsky, H.L. Biochem. J. (2005) [Pubmed]
  5. Characterization of the avian GLUT1 glucose transporter: differential regulation of GLUT1 and GLUT3 in chicken embryo fibroblasts. Wagstaff, P., Kang, H.Y., Mylott, D., Robbins, P.J., White, M.K. Mol. Biol. Cell (1995) [Pubmed]
  6. Overexpression of hexokinase I but not GLUT1 glucose transporter alters concentration dependence of glucose-stimulated insulin secretion in pancreatic beta-cell line MIN6. Ishihara, H., Asano, T., Tsukuda, K., Katagiri, H., Inukai, K., Anai, M., Kikuchi, M., Yazaki, Y., Miyazaki, J., Oka, Y. J. Biol. Chem. (1994) [Pubmed]
  7. Differential expression of glucose transporters during chick embryogenesis. Carver, F.M., Shibley, I.A., Pennington, J.S., Pennington, S.N. Cell. Mol. Life Sci. (2001) [Pubmed]
  8. Inhibition of the UDP-N-acetylgalactosamine: GM3, N-acetylgalactosaminyl transferase by gangliosides. Nores, G.A., Caputto, R. J. Neurochem. (1984) [Pubmed]
  9. Glucose transporter expression in English sparrows (Passer domesticus). Sweazea, K.L., Braun, E.J. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2006) [Pubmed]
  10. Regulation of a heterologous glucose transporter promoter in chicken embryo fibroblasts. Steane, S.E., Mylott, D., White, M.K. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  11. Re-evaluating the role of astrocytes in blood-brain barrier induction. Holash, J.A., Noden, D.M., Stewart, P.A. Dev. Dyn. (1993) [Pubmed]
  12. Molecular and biochemical events during differentiation of the HD3 chicken erythroblastic cell line. Grdisa, M., White, M.K. Int. J. Biochem. Cell Biol. (2003) [Pubmed]
  13. Changes in gene expression involved in energy utilization during chicken follicle development. Seol, H.S., Sato, K., Murakami, H., Toyomizu, M., Akiba, Y. Anim. Reprod. Sci. (2006) [Pubmed]
  14. Increased intracellular localization of brain GLUT-1 transporter in response to ethanol during chick embryogenesis. Carver, F.M., Shibley, I.A., Miles, D.S., Pennington, J.S., Pennington, S.N. Am. J. Physiol. (1999) [Pubmed]
WikiGenes - Universities