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Gene Review

Jag1  -  jagged 1

Rattus norvegicus

Synonyms: Jagged1, Protein jagged-1
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Disease relevance of Jag1


High impact information on Jag1

  • Finally, the biological activity of Jagged was tested using a cell culture assay in which Jagged activates rat Notch1 expressed in myoblasts and prevents muscle cell differentiation [2].
  • It has been proposed that Jag1 has a role in specifying sensory versus nonsensory epithelium within the ear [Adam, J., Myat, A., Roux, I. L., Eddison, M., Henrique, D., Ish-Horowicz, D. & Lewis, J. (1998) Development (Cambridge, U.K.) 125, 4645--4654] [3].
  • The Notch ligand Jagged1 is required for inner ear sensory development [3].
  • Both Notch-1 and Jagged-1 proteins were upregulated in hepatocytes after partial hepatectomy up to day 4 [1].
  • A decrease of either Notch1 or Jag1 expression by antisense oligonucleotides in cultures of the developing sensory epithelium resulted in an increase in the number of hair cells [4].

Biological context of Jag1


Anatomical context of Jag1

  • Addition of recombinant Jagged-1 protein to primary cultures of hepatocytes stimulated hepatocyte DNA synthesis [1].
  • Jagged1 protein enhances the differentiation of mesenchymal stem cells into cardiomyocytes [8].
  • Jagged was expressed in distinct regions within the optic vesicle, ciliary body, and lens, with patterns that changed over time [9].
  • The differential expression of Notch receptors and their ligands, especially Jagged1, throughout thymus development plays a key role in the generation of the different CD4:CD8 cell ratios [10].
  • A low increase of ligand expression was observed near the injury with Delta1 expression along the dentin wall and Jagged1 in the stroma [11].

Regulatory relationships of Jag1

  • 3. Jagged1 protein can activate Notch signal and enhance the differentiation of MSC into cardiomyocyte, while the effect can be inhibited by DAPT [8].

Other interactions of Jag1

  • This study documents that the Notch-3 receptor, the ligand Jagged-1, and the downstream transcription factor, HESR-1, are expressed in the normal adult rat carotid artery, and that this expression is modulated after vascular injury [7].
  • Here, we examined the expression pattern of four Delta, Serrate and Lag-2 (DSL) ligands, Jagged1, Jagged2, Delta-like1 (Dl1) and Delta-like 3 (Dl3), in late embryonic and postnatal rat brain by in situ hybridization [12].

Analytical, diagnostic and therapeutic context of Jag1

  • Furthermore, injection of silencing RNA for Notch and Jagged-1 to livers 2 days before partial hepatectomy significantly suppressed proliferation of hepatocytes at days 2 to 4 of the regenerative response [1].
  • First, sequence analysis reveals substantial homology between Jagged and invertebrate ligands for the LIN-12/Notch proteins [2].
  • Among them, the expression pattern of 1 male-enriched gene, jagged homolog 1, and those of 2 female-enriched genes, p27Kip1 and p130, were confirmed to be consistent with microarray data by RT-PCR [13].


  1. Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Köhler, C., Bell, A.W., Bowen, W.C., Monga, S.P., Fleig, W., Michalopoulos, G.K. Hepatology (2004) [Pubmed]
  2. Jagged: a mammalian ligand that activates Notch1. Lindsell, C.E., Shawber, C.J., Boulter, J., Weinmaster, G. Cell (1995) [Pubmed]
  3. The Notch ligand Jagged1 is required for inner ear sensory development. Kiernan, A.E., Ahituv, N., Fuchs, H., Balling, R., Avraham, K.B., Steel, K.P., Hrabé de Angelis, M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. Notch signaling regulates the pattern of auditory hair cell differentiation in mammals. Zine, A., Van De Water, T.R., de Ribaupierre, F. Development (2000) [Pubmed]
  5. Differentiation of bone marrow cells into cells that express liver-specific genes in vitro: implication of the Notch signals in differentiation. Okumoto, K., Saito, T., Hattori, E., Ito, J.I., Adachi, T., Takeda, T., Sugahara, K., Watanabe, H., Saito, K., Togashi, H., Kawata, S. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  6. Establishment of dental epithelial cell line (HAT-7) and the cell differentiation dependent on Notch signaling pathway. Kawano, S., Morotomi, T., Toyono, T., Nakamura, N., Uchida, T., Ohishi, M., Toyoshima, K., Harada, H. Connect. Tissue Res. (2002) [Pubmed]
  7. Determinants of Notch-3 receptor expression and signaling in vascular smooth muscle cells: implications in cell-cycle regulation. Campos, A.H., Wang, W., Pollman, M.J., Gibbons, G.H. Circ. Res. (2002) [Pubmed]
  8. Jagged1 protein enhances the differentiation of mesenchymal stem cells into cardiomyocytes. Li, H., Yu, B., Zhang, Y., Pan, Z., Xu, W., Li, H. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  9. The expression and function of Notch pathway genes in the developing rat eye. Bao, Z.Z., Cepko, C.L. J. Neurosci. (1997) [Pubmed]
  10. Distinct mechanisms contribute to generate and change the CD4:CD8 cell ratio during thymus development: a role for the Notch ligand, Jagged1. Jiménez, E., Vicente, A., Sacedón, R., Muñoz, J.J., Weinmaster, G., Zapata, A.G., Varas, A. J. Immunol. (2001) [Pubmed]
  11. Activation of the Notch signaling pathway in response to pulp capping of rat molars. Løvschall, H., Tummers, M., Thesleff, I., Füchtbauer, E.M., Poulsen, K. Eur. J. Oral Sci. (2005) [Pubmed]
  12. Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells. Irvin, D.K., Nakano, I., Paucar, A., Kornblum, H.I. J. Neurosci. Res. (2004) [Pubmed]
  13. Sex-related differences in gene expression in neonatal rat hypothalamus assessed by cDNA microarray analysis. Yonehara, K., Suzuki, M., Nishihara, M. Endocr. J. (2002) [Pubmed]
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