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Gene Review

Pebp1  -  phosphatidylethanolamine binding protein 1

Rattus norvegicus

Synonyms: 23 kDa morphine-binding protein, HCNP, HCNPpp, P23K, PEBP-1, ...
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Disease relevance of Pebp1

  • Both treatments, on chronic administration, increased mRNA levels of the transcription factor polyomavirus enhancer-binding protein (PEBP) 2beta in frontal cortex (FCx) [1].

Psychiatry related information on Pebp1

  • Furthermore, several lines of evidence obtained from studies of humans and animal models suggest that certain types of memory and learning disorders are associated with abnormal accumulation and expression of HCNP analogue peptide and/or its precursor protein mRNA in the hippocampus [2].

High impact information on Pebp1


Biological context of Pebp1


Anatomical context of Pebp1


Associations of Pebp1 with chemical compounds


Other interactions of Pebp1


Analytical, diagnostic and therapeutic context of Pebp1


  1. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. Chen, G., Zeng, W.Z., Yuan, P.X., Huang, L.D., Jiang, Y.M., Zhao, Z.H., Manji, H.K. J. Neurochem. (1999) [Pubmed]
  2. Hippocampal cholinergic neurostimulating peptides (HCNP). Ojika, K., Mitake, S., Tohdoh, N., Appel, S.H., Otsuka, Y., Katada, E., Matsukawa, N. Prog. Neurobiol. (2000) [Pubmed]
  3. Differential expression of phosphatidylethanol-amine-binding protein in rat hepatoma cell lines: analyses of tumor necrosis factor-alpha-resistant cKDH-8/11 and -sensitive KDH-8/YK cells by two-dimensional gel electrophoresis. Kuramitsu, Y., Fujimoto, M., Tanaka, T., Ohata, J., Nakamura, K. Electrophoresis (2000) [Pubmed]
  4. Expression of phosphatidylethanolamine-binding protein in the male reproductive tract: immunolocalisation and expression in prepubertal and adult rat testes and epididymides. Frayne, J., McMillen, A., Love, S., Hall, L. Mol. Reprod. Dev. (1998) [Pubmed]
  5. Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein. Tohdoh, N., Tojo, S., Agui, H., Ojika, K. Brain Res. Mol. Brain Res. (1995) [Pubmed]
  6. Phosphatidylethanolamine binding protein is an abundant secretory product of haploid testicular germ cells in the rat. Saunders, P.T., McKinnell, C., Millar, M.R., Gaughan, J., Turner, K.J., Jégou, B., Syed, V., Sharpe, R.M. Mol. Cell. Endocrinol. (1995) [Pubmed]
  7. The emerging cardioinhibitory role of the hippocampal cholinergic neurostimulating peptide. Angelone, T., Goumon, Y., Cerra, M.C., Metz-Boutigue, M.H., Aunis, D., Tota, B. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  8. A 24,500 Da protein derived from rat germ cells is associated with sertoli cell secretory function. Onoda, M., Djakiew, D. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  9. Proteome analysis of conditioned medium from cultured adult hippocampal progenitors. Dahl, A., Eriksson, P.S., Persson, A.I., Karlsson, G., Davidsson, P., Ekman, R., Westman-Brinkmalm, A. Rapid Commun. Mass Spectrom. (2003) [Pubmed]
  10. A comparative proteomic analysis of the rat brain during rebound hyperphagia induced by space-restriction. Ishihara, K., Nakata, K., Yamagishi, N., Iwasaki, S., Kiriike, N., Hatayama, T. Mol. Cell. Biochem. (2005) [Pubmed]
  11. Detection of germ cell-derived proteins in testicular interstitial fluid: potential for monitoring spermatogenesis in vivo. Turner, K.J., McKinnell, C., McLaren, T.T., Qureshi, S.J., Saunders, P.T., Foster, P.M., Sharpe, R.M. J. Androl. (1996) [Pubmed]
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