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Crabp2  -  cellular retinoic acid binding protein 2

Rattus norvegicus

Synonyms: CRABP-II, Cellular retinoic acid-binding protein 2, Cellular retinoic acid-binding protein II
 
 
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High impact information on Crabp2

 

Biological context of Crabp2

 

Anatomical context of Crabp2

 

Associations of Crabp2 with chemical compounds

 

Other interactions of Crabp2

  • Although estrogen induced the appearance of both binding proteins, CRABP mRNA levels peaked between 4-24 h postestrogen treatment, whereas CRABP II mRNA levels continued to rise 48 h postestrogen treatment [6].
 

Analytical, diagnostic and therapeutic context of Crabp2

  • Northern blot analysis of CRABP-II demonstrated the highest messenger RNA expression on day 4 (the earliest time point assayed by this technique), decreasing thereafter until day 20, when it became undetectable [4].
  • The assay makes use of anion-exchange high-pressure liquid chromatography which effectively separates CRABP-II from CRABP-I, thus permitting the simultaneous quantitation of these two proteins [9].

References

  1. Cellular retinoic acid-binding protein II gene expression is directly induced by estrogen, but not retinoic acid, in rat uterus. Li, X.H., Ong, D.E. J. Biol. Chem. (2003) [Pubmed]
  2. Purification and partial characterization of a novel binding protein for retinoic acid from neonatal rat. Bailey, J.S., Siu, C.H. J. Biol. Chem. (1988) [Pubmed]
  3. Profiling and selection of genes differentially expressed in the pylorus of rat strains with different proliferative responses and stomach cancer susceptibility. Yamashita, S., Wakazono, K., Sugimura, T., Ushijima, T. Carcinogenesis (2002) [Pubmed]
  4. Localization of cellular retinoic acid-binding protein (CRABP) II and CRABP in developing rat testis. Zheng, W.L., Bucco, R.A., Schmitt, M.C., Wardlaw, S.A., Ong, D.E. Endocrinology (1996) [Pubmed]
  5. Variable expression of cellular retinol- and cellular retinoic acid-binding proteins in the rat uterus and ovary during the estrous cycle. Wardlaw, S.A., Bucco, R.A., Zheng, W.L., Ong, D.E. Biol. Reprod. (1997) [Pubmed]
  6. Regulation and localization of cellular retinol-binding protein, retinol-binding protein, cellular retinoic acid-binding protein (CRABP), and CRABP II in the uterus of the pseudopregnant rat. Bucco, R.A., Zheng, W.L., Wardlaw, S.A., Davis, J.T., Sierra-Rivera, E., Osteen, K.G., Melner, M.H., Kakkad, B.P., Ong, D.E. Endocrinology (1996) [Pubmed]
  7. Expression of the cellular retinoic acid binding proteins, type II and type I, in mature rat olfactory epithelium. Asson-Batres, M.A., Ahmad, O., Smith, W.B. Cell Tissue Res. (2003) [Pubmed]
  8. The presence of a novel cellular retinoic acid-binding protein in chick embryos: purification and partial characterization. Kitamoto, T., Momoi, T., Momoi, M. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  9. Unique tissue distribution of two distinct cellular retinoic acid binding proteins in neonatal and adult rat. Bailey, J.S., Siu, C.H. Biochim. Biophys. Acta (1990) [Pubmed]
 
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