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Gene Review

SPA17  -  sperm autoantigenic protein 17

Homo sapiens

Synonyms: CT22, Cancer/testis antigen 22, SP17, SP17-1, Sp17-1, ...
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Disease relevance of SPA17


Psychiatry related information on SPA17

  • Two synthetic peptides corresponding to the reported 28-residue sequence of Alzheimer's Disease beta-protein (SP28) and to residues 12-28 (SP17) were used to form fibrils in vitro [5].

High impact information on SPA17


Biological context of SPA17


Anatomical context of SPA17


Associations of SPA17 with chemical compounds


Regulatory relationships of SPA17

  • Moreover, the Sp17 transcript was found differentially expressed in a RA synovial library that was subtracted with an OA synovial library [14].

Other interactions of SPA17


Analytical, diagnostic and therapeutic context of SPA17


  1. Characterization of sperm protein 17 in human somatic and neoplastic tissue. De Jong, A., Buchli, R., Robbins, D. Cancer Lett. (2002) [Pubmed]
  2. Expression of sperm protein 17 (Sp17) in ovarian cancer. Straughn, J.M., Shaw, D.R., Guerrero, A., Bhoola, S.M., Racelis, A., Wang, Z., Chiriva-Internati, M., Grizzle, W.E., Alvarez, R.D., Lim, S.H., Strong, T.V. Int. J. Cancer (2004) [Pubmed]
  3. Sperm protein 17 (Sp17) in multiple myeloma: opportunity for myeloma-specific donor T cell infusion to enhance graft-versus-myeloma effect without increasing graft-versus-host disease risk. Chiriva-Internati, M., Wang, Z., Xue, Y., Bumm, K., Hahn, A.B., Lim, S.H. Eur. J. Immunol. (2001) [Pubmed]
  4. Sperm protein 17 expression defines 2 subsets of primary esthesioneuroblastoma. Bumm, K., Grizzi, F., Franceschini, B., Koch, M., Iro, H., Wurm, J., Ceva-Grimaldi, G., Dimmler, A., Cobos, E., Dioguardi, N., Sinha, U.K., Kast, W.M., Chiriva-Internati, M. Hum. Pathol. (2005) [Pubmed]
  5. In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to Alzheimer's disease beta-protein. Castaño, E.M., Ghiso, J., Prelli, F., Gorevic, P.D., Migheli, A., Frangione, B. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  6. Sperm protein 17 (Sp17) is a suitable target for immunotherapy of multiple myeloma. Chiriva-Internati, M., Wang, Z., Salati, E., Bumm, K., Barlogie, B., Lim, S.H. Blood (2002) [Pubmed]
  7. Sperm protein 17 is not expressed on normal leukocytes. Grizzi, F., Lim, S.H., Chiriva-Internati, M., Franceschini, B., Wang, Z., Lawrence, D., Dioguardi, N. Blood (2002) [Pubmed]
  8. Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model. Buchli, R., De Jong, A., Robbins, D.L. Biochim. Biophys. Acta (2002) [Pubmed]
  9. Differentially expressed genes in the prostate cancer cell line LNCaP after exposure to androgen and anti-androgen. Coutinho-Camillo, C.M., Salaorni, S., Sarkis, A.S., Nagai, M.A. Cancer Genet. Cytogenet. (2006) [Pubmed]
  10. Sequence of a rabbit sperm zona pellucida binding protein and localization during the acrosome reaction. Richardson, R.T., Yamasaki, N., O'Rand, M.G. Dev. Biol. (1994) [Pubmed]
  11. Characterization of Sp17: a ubiquitous three domain protein that binds heparin. Wen, Y., Richardson, R.T., Widgren, E.E., O'Rand, M.G. Biochem. J. (2001) [Pubmed]
  12. Identification of a sperm protein 17 CTL epitope restricted by HLA-A1. Chiriva-Internati, M., Wang, Z., Pochopien, S., Salati, E., Lim, S.H. Int. J. Cancer (2003) [Pubmed]
  13. Sp17 gene expression in myeloma cells is regulated by promoter methylation. Wang, Z., Zhang, Y., Ramsahoye, B., Bowen, D., Lim, S.H. Br. J. Cancer (2004) [Pubmed]
  14. Developmental considerations of sperm protein 17 gene expression in rheumatoid arthritis synoviocytes. Takeoka, Y., Kenny, T.P., Yago, H., Naiki, M., Gershwin, M.E., Robbins, D.L. Dev. Immunol. (2002) [Pubmed]
  15. MAGE-C1 (CT7) gene expression in multiple myeloma: relationship to sperm protein 17. Lim, S.H., Bumm, K., Chiriva-Internati, M., Chiriva-Intemati, M., Xue, Y., Wang, Z. Eur. J. Haematol. (2001) [Pubmed]
  16. Pattern of gene expression and immune responses to Semenogelin 1 in chronic hematologic malignancies. Zhang, Y., Wang, Z., Liu, H., Giles, F.J., Lim, S.H. J. Immunother. (2003) [Pubmed]
  17. Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17. Lea, I.A., Richardson, R.T., Widgren, E.E., O'Rand, M.G. Biochim. Biophys. Acta (1996) [Pubmed]
  18. Is sperm protein 17 a useful target for tumor immunotherapy? Chiriva-Internati, M., Grizzi, F., Franceschini, B., Hermonat, P.L., Bright, R.K., Bumm, K., Dioguardi, N., Kast, W.M. Blood (2003) [Pubmed]
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