Disease relevance of HLA-DQB3

• A genomic clone specifying a new HLA class II antigen beta chain, DQB3, was isolated from a human genomic phage library using a DQB1 cDNA probe under low stringency conditions [1].

High impact information on HLA-DQB3

• This region encompasses 280 kb of DNA, including DQ alpha, DQ beta, DX alpha, DX beta, DO beta, and recently indentified L chain sequences termed DV beta [2].
• Insoluble polymer alternatives to DVB crosslinked polystyrene discussed include porous polyethylene supports, polymer-supported functional colloids, micron and submicron-sized particles and hollow spheres and one-dimensional supports [3].
• The methodology involves the use of poly(styrene-divinylbenzene) beads containing pendant octadecyl moieties (C(18)-PS/DVB), which are preimpregnated with a selective organic metal chelating agent prior to the automatic manipulation of the beads in the microbore conduits of the LOV unit [4].
• A range of PS-DVB resins were prepared by suspension polymerization with styrene, p-chloromethyl styrene, and DVB [5].
• Both the poly(dimethylsiloxane) (PDMS) and poly(dimethylsiloxane)/divinylbenzene (PDMS/DVB) fiber coating phases were tested, with the latter employing on-fiber derivatization for reactive carbonyl compounds, e.g., formaldehyde [6].

Biological context of HLA-DQB3

• Mapping and nucleotide sequence of a new HLA class II light chain gene, DQB3 [1].
• The DQB3 sequence mapped between DQA2 and DQB1, 15 kb upstream from DQA2, by analysis of overlapping cosmid clones [1].
• DQB3 and DQB4 are two quite divergent genes only present in certain duplicated haplotypes [7].
• The polydimethylsiloxane-divinylbenzene (PDMS/DVB) fiber was the most suitable for preconcentrating the analytes from the headspace of an aqueous solution containing the dissolved honey samples where the chlorophenols had been submitted to acetylation [8].
• Hydrogen transfer reduction was performed with amino alcohols derived from poly((S)-(GMA-co-EGDMA or DVB)) and hydrogenation with BINAP grafted onto PEG or copolymerized with isocyanates as ligands [9].

Associations of HLA-DQB3 with chemical compounds

• In this paper, we report the development and application of derivatized carrier materials [cellulose, silica, poly(glycidyl methacrylate/divinylbenzene) (GMA/DVB) particles, and diamond powder] for fast and direct MALDI-TOF MS protein profiling [10].
• The PDMS/DVB fibre was found to be most suitable and was used to characterize emissions of P. sylvestris enclosed in dynamic branch enclosure cuvettes by exposure for 1min followed by desorption and separation on a beta-cyclodextrin column installed in the GC/MS oven [11].
• Finally, the selectivity of the fluorinated LTGC for halogenated compounds was compared to that of commercially available SPME fibers, such as poly(dimethylsiloxane), poly(dimethylsiloxane)/divinylbenzene (PDMS/DVB), and poly(dimethylsiloxane)/Carboxen (PDMS/Carboxen) fibers [12].
• The poly(dimethylsiloxane)/divinylbenzene (PDMS/DVB) fiber was used and O-2,3,4,5,6-(pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA) were first loaded onto the fiber [13].
• An increase of biocide incorporation in the PS/DVB beads was accompanied by a corresponding enhancement of its concentration in liquid mixtures [14].

Analytical, diagnostic and therapeutic context of HLA-DQB3

• BODIPY dyes were covalently attached to polystyrene (8.8 microm, 55% DVB) microsphere particles to generate four fluorescently encoded sets [15].
• Twenty nonseminoma patients were treated with adjuvant chemotherapy using vincristine and bleomycin (OB) or cisplatin/dactinomycin, vinblastine, and bleomycin (P/DVB) [16].
• Headspace solid-phase microextraction coupled to gas chromatography/ion trap mass spectrometry-65 microm polydimethylsiloxane/divinylbenzene (PDMS/DVB) was used to identify and monitor the emission patterns of biogenic volatile organic compounds from leaves of Eucalyptus dunnii, Eucalyptus saligna, and Eucalyptus citriodora in situ [17].
• Cisplatin, vindesine, and bleomycin (DVB) combination chemotherapy for esophageal carcinoma [18].

References