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Gene Review

ctp  -  cut up

Drosophila melanogaster

Synonyms: 8 kDa dynein light chain, CG6998, Cdlc1, Ctp, Cut up protein, ...
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Disease relevance of ctp

  • Interactions between TcTex-1 and a diverse set of proteins such as the dynein intermediate chain, Fyn, DOC2, FIP1, the poliovirus receptor, CD155, and the rhodopsin cytoplasmic tail have been reported; yet, despite the broad range of targets, a consensus binding sequence remains uncertain [1].
  • Wolbachia utilizes host microtubules and Dynein for anterior localization in the Drosophila oocyte [2].
  • Consequently, the complete lack of the outer dynein arms in Threads- males most probably causes sperm immotility and hence infertility of the fly [3].

High impact information on ctp


Biological context of ctp


Anatomical context of ctp

  • A quantitative assay showed that average number of elongation cones was reduced, they were increasingly deformed, and average cyst lengths were shortened in ddlc1 hemizygous testes [11].

Associations of ctp with chemical compounds

  • The observation that dimeric LC8 dissociates at low pH can be explained by titration of a histidine pair in the dimer interface [6].
  • Ciona outer arm dynein contains six light chains (LC) including a leucine-rich repeat protein, Tctex1- and Tctex2-related proteins, a protein similar to Drosophila roadblock and two components related to Chlamydomonas LC8 [12].

Physical interactions of ctp

  • We propose that Swa acts as an adaptor for the dynein complex and thereby enables dynein to transport bcd RNA along microtubules to their minus ends at the anterior pole of the oocyte [4].

Regulatory relationships of ctp


Other interactions of ctp

  • Upon addition of LC8, N-IC74 undergoes a significant conformational change from largely unfolded to a more ordered structure [14].
  • 8. Far-UV CD and fluorescence spectra demonstrate that pH-dissociated LC8 retains native secondary and tertiary structures, while the diminished near-UV CD signal shows loss of quaternary structure [6].
  • The deduced amino acid sequence of its open reading frame exhibits high homology to members of the recently discovered roadblock/LC7 protein family (robl/LC7) of dynein-associated proteins [15].

Analytical, diagnostic and therapeutic context of ctp


  1. Crystal structure of dynein light chain TcTex-1. Williams, J.C., Xie, H., Hendrickson, W.A. J. Biol. Chem. (2005) [Pubmed]
  2. Wolbachia utilizes host microtubules and Dynein for anterior localization in the Drosophila oocyte. Ferree, P.M., Frydman, H.M., Li, J.M., Cao, J., Wieschaus, E., Sullivan, W. PLoS Pathog. (2005) [Pubmed]
  3. The Y chromosomal fertility factor Threads in Drosophila hydei harbors a functional gene encoding an axonemal dynein beta heavy chain protein. Kurek, R., Reugels, A.M., Glätzer, K.H., Bünemann, H. Genetics (1998) [Pubmed]
  4. The molecular motor dynein is involved in targeting swallow and bicoid RNA to the anterior pole of Drosophila oocytes. Schnorrer, F., Bohmann, K., Nüsslein-Volhard, C. Nat. Cell Biol. (2000) [Pubmed]
  5. Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster. Dick, T., Ray, K., Salz, H.K., Chia, W. Mol. Cell. Biol. (1996) [Pubmed]
  6. Dimerization and folding of LC8, a highly conserved light chain of cytoplasmic dynein. Barbar, E., Kleinman, B., Imhoff, D., Li, M., Hays, T.S., Hare, M. Biochemistry (2001) [Pubmed]
  7. Interactions of LC8 with N-terminal segments of the intermediate chain of cytoplasmic dynein. Nyarko, A., Hare, M., Makokha, M., Barbar, E. ScientificWorldJournal (2003) [Pubmed]
  8. Dynein light chain LC8 promotes assembly of the coiled-coil domain of swallow protein. Wang, L., Hare, M., Hays, T.S., Barbar, E. Biochemistry (2004) [Pubmed]
  9. Drosophila DPP2C1, a novel member of the protein phosphatase 2C (PP2C) family. Dick, T., Bahri, S.M., Chia, W. Gene (1997) [Pubmed]
  10. Light chains of mammalian cytoplasmic dynein: identification and characterization of a family of LC8 light chains. Wilson, M.J., Salata, M.W., Susalka, S.J., Pfister, K.K. Cell Motil. Cytoskeleton (2001) [Pubmed]
  11. Cytoplasmic dynein-dynactin complex is required for spermatid growth but not axoneme assembly in Drosophila. Ghosh-Roy, A., Kulkarni, M., Kumar, V., Shirolikar, S., Ray, K. Mol. Biol. Cell (2004) [Pubmed]
  12. Molecular characterization of Ciona sperm outer arm dynein reveals multiple components related to outer arm docking complex protein 2. Hozumi, A., Satouh, Y., Makino, Y., Toda, T., Ide, H., Ogawa, K., King, S.M., Inaba, K. Cell Motil. Cytoskeleton (2006) [Pubmed]
  13. Dynein light chain 1 regulates dynamin-mediated F-actin assembly during sperm individualization in Drosophila. Ghosh-Roy, A., Desai, B.S., Ray, K. Mol. Biol. Cell (2005) [Pubmed]
  14. Interactions of cytoplasmic dynein light chains Tctex-1 and LC8 with the intermediate chain IC74. Makokha, M., Hare, M., Li, M., Hays, T., Barbar, E. Biochemistry (2002) [Pubmed]
  15. A cDNA from the green alga Spermatozopsis similis encodes a protein with homology to the newly discovered Roadblock/LC7 family of dynein-associated proteins. Dole, V., Jakubzik, C.R., Brünjes, B., Kreimer, G. Biochim. Biophys. Acta (2000) [Pubmed]
  16. Phylogeny and expression of axonemal and cytoplasmic dynein genes in sea urchins. Gibbons, B.H., Asai, D.J., Tang, W.J., Hays, T.S., Gibbons, I.R. Mol. Biol. Cell (1994) [Pubmed]
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