Disease relevance of Juvenile hormone

• Juvenile hormone mimetic activities on Aedes aegypti (yellow-fever mosquito) and Tenebrio molitor (yellow mealworm) of compounds having (2E,4E)-3,7,11-trimethyl-2,4-dodecadienone structures were comparatively and quantitatively analyzed in terms of their physiochemical structural parameters and by regression analysis [1].
• The cDNA of the microsomal Juvenile Hormone Epoxide Hydrolase (JHEH) from Manduca sexta was expressed in vitro in the baculovirus system [2].
• Juvenile hormone regulates oviposition in Drosophila exposed to heat stress [3].

Psychiatry related information on Juvenile hormone

• The commitment of cells to pupal development in the larvae of holometabolous insects can be prevented by treatment with juvenile hormone (JH) or a JH mimic during a critical period early in the last larval instar [4].
• Juvenile hormone, stored in male accessory sex glands (ASG), may be transferred to the female during copulation, but the physiological significance of the JH transfer remains unclear [5].
• It is also known that both the insulin pathway and JH play a role in the control of sexual dimorphism in locomotor activity [6].

High impact information on Juvenile hormone

• Vitellogenins are yolk protein precursors that are synthesised in the liver of lower vertebrates in response to ovarian hormones, and in the fat body tissue of insects, under the influence, in most species, of juvenile hormone (JH) from the corpora allata (CA) [7].
• In insects, on the other hand, because the CA of adults of both sexes are active, it appeared that male fat body could not normally respond to JH by synthesising vitellogenin [7].
• We report here that synthesis of vitellogenin can indeed be induced in males of Diploptera by implantation of female CA or application of Diploptera by implantation of female CA or application of a JH analogue, ZR512 (Zoecon), and that implanted oocytes take up the vitellogenin [7].
• Letter: Juvenile hormone and pest control [8].
• Subspecies differences in onset age of foraging were correlated with differences in JH and JH-target gene expression, suggesting that this endocrine system mediates the genetic differences [9].

Biological context of Juvenile hormone

• Previous results have demonstrated a mechanism of resistance involving an intracellular JH binding protein that has reduced ligand affinity in Met flies [10].
• Apoptosis is suppressed by Juvenile hormone analog treatment of females under nutritional shortage [11].
• Juvenile hormone (JH) esterase found primarily in the hemolymph and tissues of insects is a low abundance protein involved in the ester hydrolysis of insect juvenile hormones, JHs [12].
• Juvenile hormone diol kinase. I. Purification, characterization, and substrate specificity of juvenile hormone-selective diol kinase from Manduca sexta [13].
• Two hormones, 20-hydroxyecdysone (20E) and juvenile hormone (JH), coordinately orchestrate insect growth and development [14].

Anatomical context of Juvenile hormone

• MN-1 and MN-3 show different times of JH sensitivity, which appear to be correlated with different times of neurite outgrowth [15].
• Juvenile hormone regulation of mRNA levels for a highly abundant hemolymph protein in larval Trichoplusia ni [16].
• We showed that JH increased mushroom body neuroblast (MBNb) proliferation, confirming the mitogenic effect of JH observed in vivo [17].
• We explored the stability of this neuropil expansion and its possible dependence on JH [18].
• Juvenile hormone binding by components of fat body cytosol from vitellogenic locusts [19].

Associations of Juvenile hormone with other chemical compounds

• Both farnesol and JH stimulated INV and transglutaminase promoter activity, suggesting regulation at the transcriptional level [20].
• The isoprenoids farnesol and juvenile hormone III (JH), metabolites of the cholesterol biosynthetic pathway, have been shown to stimulate fetal epidermal development in rodents [20].
• There are major changes in the sensitivity of corpora allata from the cockroach Diploptera punctata toward the allatostatic tridecapeptide APSGAQRLYGFGL-amide (ASAL) during the female reproductive cycle, as revealed by measurement of juvenile hormone (JH) biosynthesis in vitro [21].
• The behavioral shift from nest-task to foraging activity is accompanied by physiological and sensory changes so that foragers can be characterized by a higher juvenile hormone (JH) level, a lower vitellogenin protein titer, and an increased responsiveness to water and sucrose stimuli [22].
• Allatostatins VI and VII also resemble the other allatostatins in their ability to affect both larval and adult CA, in the reversibility of their effect, and in the abolition of their effect by addition of farnesoic acid (a late precursor of JH) to CA in vitro [23].

Gene context of Juvenile hormone

• However, JH III repressed 20E activation of br in 3-to 5-day-old females, indicating a switch in hormonal commitment [24].
• Juvenile hormone potentiates ecdysone receptor-dependent transcription in a mammalian cell culture system [25].
• Dup99B, with no appreciable homology to SP in the N-terminal region, similarly lacks an effect on JH production by H. armigera CA [26].
• Juvenile hormone (JH) is a major regulator of insect development and reproduction and its titer is determined largely by central nervous system regulation of JH synthesis by the corpora allata [27].
• Juvenile hormone stimulation of ornithine decarboxylase activity during vitellogenesis in Drosophila melanogaster [28].

Analytical, diagnostic and therapeutic context of Juvenile hormone

• In bioassays, the Y/FXFGL-NH(2) allatostatins did not inhibit JH synthesis by CA of L. oleracea [29].
• Juvenile hormone regulation and developmental expression of a Tenebrio desiccation stress protein gene [30].
• Circulating levels of juvenile hormone (JH) in these drones were determined by radioimmunoassay (RIA) [31].
• Gel retardation assay using specific antibody revealed that a PBX protein binds to the JH response element [32].
• We detected only JH III in these animals in contrast to prior studies in which JH I, II, and/or III had been reported using a different scheme relying on HPLC purification and subsequent GC/MS analysis under chemical ionization (CI) conditions [33].

References