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Gene Review

IMPA2  -  inositol(myo)-1(or 4)-monophosphatase 2

Homo sapiens

Synonyms: IMP 2, IMP.18P, IMPase 2, Inositol monophosphatase 2, Inositol-1(or 4)-monophosphatase 2, ...
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Disease relevance of IMPA2


Psychiatry related information on IMPA2


High impact information on IMPA2

  • Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder [3].
  • Intriguingly, two frequent single-nucleotide polymorphisms (-461C>T and -207T>C) in the IMPA2 promoter sequence and their corresponding haplotypes showed transmission disequilibrium in the Palestinian Arab trios [3].
  • Collectively, these observations suggest a potential sex-dependent link between abnormalities in IMPA2 expression and calcium homeostasis in the pathophysiology of BD [6].
  • These findings increase the relevance of 18p11.2 to schizophrenia susceptibility because GNAL, which has been shown previously to be implicated in schizophrenia in an independent study, is in close physical proximity to IMPA2 [4].
  • Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples [4].

Chemical compound and disease context of IMPA2


Biological context of IMPA2


Anatomical context of IMPA2


Associations of IMPA2 with chemical compounds


Other interactions of IMPA2

  • 2. In the present study, we have scanned for DNA variants in the human IMPA1 and IMPA2 genes in a pilot sample of Norwegian manic-depressive patients, followed by examination of selected polymorphisms and haplotypes in a family-based bipolar sample of Palestinian Arab proband-parent trios [3].
  • Whereas most previous positive findings were not supported by subsequent studies, DRD1 and IMPA2 have been implicated in follow-up studies [12].

Analytical, diagnostic and therapeutic context of IMPA2

  • The stability constants of the 1:1 complexes formed between Pb2+ and the nucleosides (Ns), adenosine and guanosine, as well as between the nucleotides (NMP2-), AMP2-, IMP2-, and GMP2-, were determined by potentiometric pH titrations in aqueous solution (25 degrees C; I = 0.1 M, NaNO3) [11].


  1. Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients. Blair, M.A., Ma, S., Abou-Khalil, B., Hedera, P. Eur. J. Neurol. (2007) [Pubmed]
  2. Identification of a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae. Yan, J.J., Ko, W.C., Wu, J.J. Antimicrob. Agents Chemother. (2001) [Pubmed]
  3. Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder. Sjøholt, G., Ebstein, R.P., Lie, R.T., Berle, J.Ø., Mallet, J., Deleuze, J.F., Levinson, D.F., Laurent, C., Mujahed, M., Bannoura, I., Murad, I., Molven, A., Steen, V.M. Mol. Psychiatry (2004) [Pubmed]
  4. Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples. Yoshikawa, T., Kikuchi, M., Saito, K., Watanabe, A., Yamada, K., Shibuya, H., Nankai, M., Kurumaji, A., Hattori, E., Ishiguro, H., Shimizu, H., Okubo, Y., Toru, M., Detera-Wadleigh, S.D. Mol. Psychiatry (2001) [Pubmed]
  5. A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription. Ohnishi, T., Yamada, K., Ohba, H., Iwayama, Y., Toyota, T., Hattori, E., Inada, T., Kunugi, H., Tatsumi, M., Ozaki, N., Iwata, N., Sakamoto, K., Iijima, Y., Iwata, Y., Tsuchiya, K.J., Sugihara, G., Nanko, S., Osumi, N., Detera-Wadleigh, S.D., Kato, T., Yoshikawa, T. Neuropsychopharmacology (2007) [Pubmed]
  6. Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder. Yoon, I.S., Li, P.P., Siu, K.P., Kennedy, J.L., Cooke, R.G., Parikh, S.V., Warsh, J.J. Mol. Psychiatry (2001) [Pubmed]
  7. Genomic structure and novel variants of myo-inositol monophosphatase 2 (IMPA2). Yoshikawa, T., Padigaru, M., Karkera, J.D., Sharma, M., Berrettini, W.H., Esterling, L.E., Detera-Wadleigh, S.D. Mol. Psychiatry (2000) [Pubmed]
  8. A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients. Sjøholt, G., Gulbrandsen, A.K., Løvlie, R., Berle, J.O., Molven, A., Steen, V.M. Mol. Psychiatry (2000) [Pubmed]
  9. Lithium modulation of the human inositol monophosphatase 2 (IMPA2) promoter. Seelan, R.S., Parthasarathy, L.K., Parthasarathy, R.N. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  10. Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18. Nakayama, J., Yamamoto, N., Hamano, K., Iwasaki, N., Ohta, M., Nakahara, S., Matsui, A., Noguchi, E., Arinami, T. Neurology (2004) [Pubmed]
  11. Lead(II)-binding properties of the 5'-monophosphates of adenosine (AMP2-), inosine (IMP2-), and guanosine (GMP2-) in aqueous solution. Evidence for nucleobase-lead(II) interactions. Da Costa, C.P., Sigel, H. Inorganic chemistry. (2000) [Pubmed]
  12. Molecular genetics of bipolar disorder and depression. Kato, T. Psychiatry Clin. Neurosci. (2007) [Pubmed]
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