The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

IRAK2  -  interleukin-1 receptor-associated kinase 2

Homo sapiens

Synonyms: IRAK-2, Interleukin-1 receptor-associated kinase-like 2
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on IRAK2


Biological context of IRAK2


Anatomical context of IRAK2

  • Deletion of the ZIP or AP-2 sites did not significantly affect IRAK2 promoter activity in naive and endotoxin-treated mononuclear cells, in dormant and activated Jurkat T-cells, in lung and kidney cells [4].
  • Antisense IRAK-2 ODN was delivered by lipofectin encapsulation into cultured endothelial cells [6].

Associations of IRAK2 with chemical compounds

  • IRAK-2 plays a key role in the IL-1 signaling events leading to PGI2 release [7].
  • Phosphorothioate oligodeoxynucleotide (ODN) was designed antisense to sequences of the recently cloned human IL-1 receptor associated kinase-2 (IRAK-2) [6].

Physical interactions of IRAK2

  • This assay revealed a CTCF-binding site within the mouse Irak2 promoter [4].

Regulatory relationships of IRAK2


Other interactions of IRAK2

  • In this paper, we report that IRAK2 and MyD88, but not IRAK1, interact physically with Akt, as demonstrated by co-immunoprecipitation and pull-down experiments [5].
  • Interestingly, the association of Akt with recombinant IRAK2 is decreased by stimulation with IL-1, and is favoured by pre-treatment with phosphatase [5].
  • METHODS: The HUVEC were transfected with antisense IRAK-2 ODN and stimulated with IL-1 and TNF [7].
  • A maximum inhibition of NF-KB activation or surface expression of ICAM-1 occurred when the cells were incubated with antisense IRAK-2 ODN 3 microg for 8 h [6].
  • The attenuation of the cellular response to IL-1 caused by antisense IRAK-2 ODN correlated with a reduction of IRAK-2 expression [6].

Analytical, diagnostic and therapeutic context of IRAK2

  • The levels of NF-KB, surface expression of intracellular adhesion molecule-1 (ICAM-1), ICAM-1 and IRAK-2 mRNAs were measured by sandwich ELISA, ELISA on cells in situ, and semiquantitative reverse transcription-PCR (RT-PCR), respectively [6].


  1. Localization of the Fanconi anemia complementation group D gene to a 200-kb region on chromosome 3p25.3. Hejna, J.A., Timmers, C.D., Reifsteck, C., Bruun, D.A., Lucas, L.W., Jakobs, P.M., Toth-Fejel, S., Unsworth, N., Clemens, S.L., Garcia, D.K., Naylor, S.L., Thayer, M.J., Olson, S.B., Grompe, M., Moses, R.E. Am. J. Hum. Genet. (2000) [Pubmed]
  2. Vaccinia virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10. Maloney, G., Schröder, M., Bowie, A.G. J. Biol. Chem. (2005) [Pubmed]
  3. Regulation of IL-1 receptor-associated kinases by lipopolysaccharide. Hu, J., Jacinto, R., McCall, C., Li, L. J. Immunol. (2002) [Pubmed]
  4. Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter. Kuzmin, I., Geil, L., Gibson, L., Cavinato, T., Loukinov, D., Lobanenkov, V., Lerman, M.I. J. Mol. Biol. (2005) [Pubmed]
  5. Interleukin-1-receptor-associated kinase 2 (IRAK2)-mediated interleukin-1-dependent nuclear factor kappaB transactivation in Saos2 cells requires the Akt/protein kinase B kinase. Cenni, V., Sirri, A., De Pol, A., Maraldi, N.M., Marmiroli, S. Biochem. J. (2003) [Pubmed]
  6. Antisense IRAK-2 oligonucleotide blocks IL-1-stimulated NF-kappaB activation and ICAM-1 expression in cultured endothelial cells. Guo, F., Li, Y., Wu, S. Inflammation (1999) [Pubmed]
  7. Effects of antisense IRAK-2 oligonucleotides on PGI2 release induced by IL-1 and TNF. Li, Y.L., Guo, F.K., Wu, S.G. Acta Pharmacol. Sin. (2000) [Pubmed]
  8. Antisense IRAK-2 oligodeoxynucleotide inhibits interleukin-1-induced nuclear factor-kappa B activation in vitro. Guo, F.K., Li, Y.L., Wu, S.G. Acta Pharmacol. Sin. (2000) [Pubmed]
  9. IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination. Keating, S.E., Maloney, G.M., Moran, E.M., Bowie, A.G. J. Biol. Chem. (2007) [Pubmed]
WikiGenes - Universities