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Gene Review

BM2  -  BM2 protein

Influenza B virus

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Disease relevance of BM2


High impact information on BM2

  • Eukaryotic coupled translation of tandem cistrons: identification of the influenza B virus BM2 polypeptide [5].
  • To understand the mechanism by which the BM2 protein is generated from influenza B virus RNA segment 7, a mutational analysis of the cloned DNA was performed and the altered DNAs were expressed in eukaryotic cells [5].
  • In an effort to explore its function, a number of BM2 mutant viruses were generated by using a reverse genetics technique [2].
  • To completely abolish BM2 expression, we generated a mutant M gene whose BM2 open reading frame was deleted [6].
  • Although this mutant was not able to replicate in normal MDCK cells, it did replicate in a cell line that we established which constitutively expresses BM2 [6].

Chemical compound and disease context of BM2


Biological context of BM2


Anatomical context of BM2


  1. Influenza B virus BM2 protein is transported through the trans-Golgi network as an integral membrane protein. Watanabe, S., Imai, M., Ohara, Y., Odagiri, T. J. Virol. (2003) [Pubmed]
  2. Influenza B virus BM2 protein is a crucial component for incorporation of viral ribonucleoprotein complex into virions during virus assembly. Imai, M., Watanabe, S., Ninomiya, A., Obuchi, M., Odagiri, T. J. Virol. (2004) [Pubmed]
  3. pH modulating activity of ion channels of influenza A, B, and C viruses. Bet??kov??, T., Kollerov??, E. Acta Virol. (2006) [Pubmed]
  4. The BM2 protein of influenza B virus is synthesized in the late phase of infection and incorporated into virions as a subviral component. Odagiri, T., Hong, J., Ohara, Y. J. Gen. Virol. (1999) [Pubmed]
  5. Eukaryotic coupled translation of tandem cistrons: identification of the influenza B virus BM2 polypeptide. Horvath, C.M., Williams, M.A., Lamb, R.A. EMBO J. (1990) [Pubmed]
  6. Influenza B virus requires BM2 protein for replication. Hatta, M., Goto, H., Kawaoka, Y. J. Virol. (2004) [Pubmed]
  7. Influenza B virus BM2 protein is an oligomeric integral membrane protein expressed at the cell surface. Paterson, R.G., Takeda, M., Ohigashi, Y., Pinto, L.H., Lamb, R.A. Virology (2003) [Pubmed]
  8. Reduced incorporation of the influenza B virus BM2 protein in virus particles decreases infectivity. Jackson, D., Zürcher, T., Barclay, W. Virology (2004) [Pubmed]
  9. Influenza B virus BM2 protein has ion channel activity that conducts protons across membranes. Mould, J.A., Paterson, R.G., Takeda, M., Ohigashi, Y., Venkataraman, P., Lamb, R.A., Pinto, L.H. Dev. Cell (2003) [Pubmed]
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