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Gene Review

KIR2DL3  -  killer cell immunoglobulin-like receptor,...

Homo sapiens

Synonyms: CD158 antigen-like family member B2, CD158B2, CD158b, GL183, KIR-023GB, ...
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Disease relevance of KIR2DL3


Psychiatry related information on KIR2DL3

  • When the reaction time of alpha-amylase was 30 min, the limit of detection was 0.5 nkat ml(-1) [6].
  • In the group with bipolar disorder, treated with lithium (7.39 nkat/l+/-3.11) and, in the group of patients treated with psychiatric drugs because of various mental disorders (7.79 nkat/l+/-8.51), the differences are statistically significant [7].

High impact information on KIR2DL3

  • The human p58 natural killer-cell inhibitory receptor clone 42 recognizes HLA-Cw4, -Cw2 and -Cw6, but not HLA-Cw3, -Cw2, -Cw7 or -Cw8, which are recognized by p58 killer-cell inhibitor receptor clone 43 [8].
  • We have determined the X-ray structure of the p58 NK-cell inhibitory receptor clone 42 at 1.7-A resolution [8].
  • Using mice that are transgenic for KIR2DL3 and its cognate HLA-Cw3 ligand, we show that engagement of inhibitory NKRs selectively drives the in vivo accumulation of a subset of memory-phenotype CD8+ T cells that express the beta chain of the interleukin 2 receptor [9].
  • Furthermore, the cytoplasmic domain of Ly-49D does not contain the V/Ix-YxxL immunoreceptor tyrosine-based inhibitory motif found in Ly-49A, C, or G2 that has been characterized in the human p58 killer inhibitory receptors [10].
  • The natural killer (NK) cell-specific p58 molecules EB6 and GL183 have been shown to represent the putative surface receptors for two distinct groups of human histocompatibility leukocyte antigen (HLA) C alleles [11].

Chemical compound and disease context of KIR2DL3


Biological context of KIR2DL3


Anatomical context of KIR2DL3


Associations of KIR2DL3 with chemical compounds

  • Two of these polypeptides can be identified as nuclear lamins A and B. The immunoisolate also contains a kinase activity that phosphorylates p58 in vivo and in vitro, exclusively at serine residues, as indicated by phosphoamino acid analysis and two-dimensional phosphopeptide mapping [24].
  • Binding of p58 to T3 and its analogs resulted in the inhibition of its pyruvate kinase activity [25].
  • Conversion of p58 to the tetramer is reversible and is under the control of fructose 1,6-bisphosphate [25].
  • This p58 protein was purified from the WERI-1 cell nuclear extract by ammonium sulfate precipitation, Mono Q chromatography, and immunoprecipitation with anti-Sm antibody Y12 [26].
  • Its isoelectric point was determined to be 7.1, which is different from the reported pIs of other thyroid hormone binding proteins. p58 was successively purified to apparent homogeneity by chromatography on Sephadex G-200, QAE-Sephadex, SP-Sephadex, and hydroxylapatite [27].

Regulatory relationships of KIR2DL3

  • First, we show using plastic-immobilized CD158b mAb that the activating KIR2DS2 is stimulated, resulting in NK cell division and degranulation [28].

Other interactions of KIR2DL3


Analytical, diagnostic and therapeutic context of KIR2DL3

  • As expected, mixed lymphocyte reaction and anti-CD3 monoclonal antibody (MoAb)-redirected cytotoxicity exerted by freshly isolated splenocytes can be inhibited by engagement of transgenic KIR2DL3 molecules [20].
  • Molecular cloning of the p58 NK receptor reported here revealed a new member of the immunoglobulin superfamily [33].
  • Crystallization and preliminary diffraction studies of the extracellular region of human p58 killer cell inhibitory receptor (KIR2) [2].
  • Double immunofluorescence staining with A803g and anti-CD56 Ab showed that CD56 and p58 or p50 were expressed on NK cells in a mutually exclusive way [34].
  • MAIN OUTCOME MEASURE(S): NK cytotoxicity was determined by assay of (51)Cr release against K562 cells, and the expression of killer cell inhibitory receptors (KIR, including NKB1, GL183, and EB6) in NK cells was examined by flow cytometry [35].


  1. Killer cell inhibitory receptors for MHC class I molecules regulate lysis of melanoma cells mediated by NK cells, gamma delta T cells, and antigen-specific CTL. Bakker, A.B., Phillips, J.H., Figdor, C.G., Lanier, L.L. J. Immunol. (1998) [Pubmed]
  2. Crystallization and preliminary diffraction studies of the extracellular region of human p58 killer cell inhibitory receptor (KIR2). Maenaka, K., Juji, T., Tadokoro, K., Harlos, K., Stuart, D.I., Jones, E.Y. Acta Crystallogr. D Biol. Crystallogr. (1998) [Pubmed]
  3. TCR gamma delta cytotoxic T lymphocytes expressing the killer cell-inhibitory receptor p58.2 (CD158b) selectively lyse acute myeloid leukemia cells. Dolstra, H., Fredrix, H., van der Meer, A., de Witte, T., Figdor, C., van de Wiel-van Kemenade, E. Bone Marrow Transplant. (2001) [Pubmed]
  4. Decreased expression of killer cell inhibitory receptors on natural killer cells in eutopic endometrium in women with adenomyosis. Yang, J.H., Chen, M.J., Chen, H.F., Lee, T.H., Ho, H.N., Yang, Y.S. Hum. Reprod. (2004) [Pubmed]
  5. Killer inhibitory receptor (CD158b) modulates the lytic activity of tumor-specific T lymphocytes infiltrating renal cell carcinomas. Guerra, N., Guillard, M., Angevin, E., Echchakir, H., Escudier, B., Moretta, A., Chouaib, S., Caignard, A. Blood (2000) [Pubmed]
  6. A biosensor for the determination of amylase activity. Zajoncová, L., Jílek, M., Beranová, V., Pec, P. Biosensors & bioelectronics. (2004) [Pubmed]
  7. Serum alcohol dehydrogenase levels in patients with mental disorders. Kravos, M., Malesic, I., Levanic, S. Clin. Chim. Acta (2005) [Pubmed]
  8. Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors. Fan, Q.R., Mosyak, L., Winter, C.C., Wagtmann, N., Long, E.O., Wiley, D.C. Nature (1997) [Pubmed]
  9. Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells. Ugolini, S., Arpin, C., Anfossi, N., Walzer, T., Cambiaggi, A., Förster, R., Lipp, M., Toes, R.E., Melief, C.J., Marvel, J., Vivier, E. Nat. Immunol. (2001) [Pubmed]
  10. The Ly-49D receptor activates murine natural killer cells. Mason, L.H., Anderson, S.K., Yokoyama, W.M., Smith, H.R., Winkler-Pickett, R., Ortaldo, J.R. J. Exp. Med. (1996) [Pubmed]
  11. Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells. Moretta, A., Sivori, S., Vitale, M., Pende, D., Morelli, L., Augugliaro, R., Bottino, C., Moretta, L. J. Exp. Med. (1995) [Pubmed]
  12. HLA-C and HLA-E reduce antibody-dependent natural killer cell-mediated cytotoxicity of HIV-infected primary T cell blasts. Ward, J.P., Bonaparte, M.I., Barker, E. AIDS (2004) [Pubmed]
  13. Purification and properties of an iron-sulfur-containing and pyridoxal-phosphate-independent L-serine dehydratase from Peptostreptococcus asaccharolyticus. Grabowski, R., Buckel, W. Eur. J. Biochem. (1991) [Pubmed]
  14. Orosomucoid and haptoglobin types in patients with sarcoidosis. Fan, C., Nylander, P.O., Sikström, C., Thunell, M. Exp. Clin. Immunogenet. (1995) [Pubmed]
  15. Expression of a leukemia-associated antigen (CAMAL) in four myeloid leukemia cell lines. Shipman, R.C., Levy, J.G. Leuk. Res. (1988) [Pubmed]
  16. Killer cell immunoglobulin receptors and T cell receptors bind peptide-major histocompatibility complex class I with distinct thermodynamic and kinetic properties. Maenaka, K., Juji, T., Nakayama, T., Wyer, J.R., Gao, G.F., Maenaka, T., Zaccai, N.R., Kikuchi, A., Yabe, T., Tokunaga, K., Tadokoro, K., Stuart, D.I., Jones, E.Y., van der Merwe, P.A. J. Biol. Chem. (1999) [Pubmed]
  17. HLA-Cw7 zygosity affects the size of a subset of CD158b+ natural killer cells. Husain, Z., Levitan, E., Larsen, C.E., Mirza, N.M., Younes, S., Yunis, E.J., Alper, C.A., Dubey, D.P. J. Clin. Immunol. (2002) [Pubmed]
  18. Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual. Chwae, Y.J., Cho, S.E., Kim, S.J., Kim, J. Immunol. Lett. (1999) [Pubmed]
  19. The direct binding of a p58 killer cell inhibitory receptor to human histocompatibility leukocyte antigen (HLA)-Cw4 exhibits peptide selectivity. Rajagopalan, S., Long, E.O. J. Exp. Med. (1997) [Pubmed]
  20. Modulation of T-cell functions in KIR2DL3 (CD158b) transgenic mice. Cambiaggi, A., Darche, S., Guia, S., Kourilsky, P., Abastado, J.P., Vivier, E. Blood (1999) [Pubmed]
  21. Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors. Leung, W., Iyengar, R., Triplett, B., Turner, V., Behm, F.G., Holladay, M.S., Houston, J., Handgretinger, R. J. Immunol. (2005) [Pubmed]
  22. Investigation of killer cell immunoglobulin-like receptor gene diversity III. KIR2DL3. Keaney, L., Williams, F., Meenagh, A., Sleator, C., Middleton, D. Tissue Antigens (2004) [Pubmed]
  23. Direct binding of a soluble natural killer cell inhibitory receptor to a soluble human leukocyte antigen-Cw4 class I major histocompatibility complex molecule. Fan, Q.R., Garboczi, D.N., Winter, C.C., Wagtmann, N., Long, E.O., Wiley, D.C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  24. The inner nuclear membrane protein p58 associates in vivo with a p58 kinase and the nuclear lamins. Simos, G., Georgatos, S.D. EMBO J. (1992) [Pubmed]
  25. Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase. Kato, H., Fukuda, T., Parkison, C., McPhie, P., Cheng, S.Y. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  26. hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells. Chou, M.Y., Rooke, N., Turck, C.W., Black, D.L. Mol. Cell. Biol. (1999) [Pubmed]
  27. A cellular 3,3',5-triiodo-L-thyronine binding protein from a human carcinoma cell line. Purification and characterization. Kitagawa, S., Obata, T., Hasumura, S., Pastan, I., Cheng, S.Y. J. Biol. Chem. (1987) [Pubmed]
  28. Biphasic response of NK cells expressing both activating and inhibitory killer Ig-like receptors. Warren, H.S., Campbell, A.J., Waldron, J.C., Lanier, L.L. Int. Immunol. (2001) [Pubmed]
  29. Natural killer cell acceptance of H-2 mismatch bone marrow grafts in transgenic mice expressing HLA-Cw3 specific killer cell inhibitory receptor. Cambiaggi, A., Verthuy, C., Naquet, P., Romagné, F., Ferrier, P., Biassoni, R., Moretta, A., Moretta, L., Vivier, E. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  30. The expression of NK cell inhibitory receptors on cytotoxic T cells in B-cell chronic lymphocytic leukaemia (B-CLL). Junevik, K., Werlenius, O., Hasselblom, S., Jacobsson, S., Nilsson-Ehle, H., Andersson, P.O. Ann. Hematol. (2007) [Pubmed]
  31. Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity. Le Bouteiller, P., Barakonyi, A., Giustiniani, J., Lenfant, F., Marie-Cardine, A., Aguerre-Girr, M., Rabot, M., Hilgert, I., Mami-Chouaib, F., Tabiasco, J., Boumsell, L., Bensussan, A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  32. Expression of HLA-C-specific natural killer cell receptors (CD158a and CD158b) on peripheral blood mononuclear cells after allogeneic bone marrow transplantation. Tanaka, J., Mori, A., Ohta, S., Yamamoto, Y., Kobayashi, S., Hashino, S., Kobayashi, M., Asaka, M., Imamura, M. Br. J. Haematol. (2000) [Pubmed]
  33. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Wagtmann, N., Biassoni, R., Cantoni, C., Verdiani, S., Malnati, M.S., Vitale, M., Bottino, C., Moretta, L., Moretta, A., Long, E.O. Immunity (1995) [Pubmed]
  34. Monoclonal antibodies with various reactivity to p58 killer inhibitory receptors. Shin, J.S., Shin, E.C., Kim, J., Choi, I.H., Park, J.H., Kim, S.J. Hybridoma (1999) [Pubmed]
  35. Increase in the expression of killer cell inhibitory receptors on peritoneal natural killer cells in women with endometriosis. Wu, M.Y., Yang, J.H., Chao, K.H., Hwang, J.L., Yang, Y.S., Ho, H.N. Fertil. Steril. (2000) [Pubmed]
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