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Gene Review

ImpE2  -  Ecdysone-inducible gene E2

Drosophila melanogaster

Synonyms: 20-HE, 20-hydroxyecdysone protein, CG1934, Dmel\CG1934, IMP-E2, ...
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High impact information on ImpE2


Biological context of ImpE2

  • Although the temporal and spatial expression of the IMP-E2 gene are consistent with a role in disc morphogenesis, its specific functions remain to be determined [6].
  • When Day 2 fourth instar epidermis was explanted before the molting ecdysteroid rise and cultured with 1-3 micrograms/ml 20-HE for 17 hr and then for 24 hr in hormone-free medium, DDC expression was three- to fourfold higher than that in epidermis cultured in the absence of hormone [7].
  • The steroid hormone 20-hydroxyecdysone (20HE) and the Broad-Complex locus (BRC) are involved in regulating developmental changes in gene expression around the time of metamorphosis in Drosophila [5].
  • The role of the 20HE in the regulation of cytochrome P450-mediated insecticide resistance has been proposed [8].
  • The 20-HE induced beta tubulin comigrates with the beta 3 subunit and like the latter, is specific to the mid period of embryogenesis [9].

Anatomical context of ImpE2


Associations of ImpE2 with chemical compounds


  1. 20-Hydroxyecdysone stimulates the accumulation of translatable yolk polypeptide gene transcript in adult male Drosophila melanogaster. Shirk, P.D., Minoo, P., Postlethwait, J.H. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  2. Ecdysone-dependent proteolysis of an apical surface glycoprotein may play a role in imaginal disc morphogenesis in Drosophila. Birr, C.A., Fristrom, D., King, D.S., Fristrom, J.W. Development (1990) [Pubmed]
  3. Prepupal differentiation in Drosophila: distinct cell types elaborate a shared structure, the pupal cuticle, but accumulate transcripts in unique patterns. Fechtel, K., Fristrom, D.K., Fristrom, J.W. Development (1989) [Pubmed]
  4. An ecdysteroid-inducible Manduca gene similar to the Drosophila DHR3 gene, a member of the steroid hormone receptor superfamily. Palli, S.R., Hiruma, K., Riddiford, L.M. Dev. Biol. (1992) [Pubmed]
  5. Hormonal control of gene expression: interactions between two trans-acting regulators in Drosophila. Nelson, R.J., Odell, G.M., Christiansen, A.E., Laird, C.D. Dev. Biol. (1991) [Pubmed]
  6. The Drosophila IMP-E2 gene encodes an apically secreted protein expressed during imaginal disc morphogenesis. Paine-Saunders, S., Fristrom, D., Fristrom, J.W. Dev. Biol. (1990) [Pubmed]
  7. Regulation of dopa decarboxylase gene expression in the larval epidermis of the tobacco hornworm by 20-hydroxyecdysone and juvenile hormone. Hiruma, K., Riddiford, L.M. Dev. Biol. (1990) [Pubmed]
  8. The expression of insecticide resistance-related cytochrome P450 forms is regulated by molting hormone in Drosophila melanogaster. Spiegelman, V.S., Fuchs, S.Y., Belitsky, G.A. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  9. Expression of a new beta tubulin subunit is induced by 20-hydroxyecdysone in Drosophila cultured cells. Sobrier, M.L., Couderc, J.L., Chapel, S., Dastugue, B. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  10. The effects of several ecdysteroids and ecdysteroid agonists on two Drosophila imaginal disc cell lines. Cottam, D.M., Milner, M.J. Cell. Mol. Life Sci. (1997) [Pubmed]
  11. Depression of synaptic efficacy in high- and low-output Drosophila neuromuscular junctions by the molting hormone (20-HE). Ruffner, M.E., Cromarty, S.I., Cooper, R.L. J. Neurophysiol. (1999) [Pubmed]
  12. Conditions for the primary culture of eye imaginal discs from Drosophila melanogaster. Li, C., Meinertzhagen, I.A. J. Neurobiol. (1995) [Pubmed]
  13. Characterization of IMP-E3, a gene active during imaginal disc morphogenesis in Drosophila melanogaster. Moore, J.T., Fristrom, D., Hammonds, A.S., Fristrom, J.W. Dev. Genet. (1990) [Pubmed]
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