Chemical Compound Review:
AC1MHYWA N-(3-chlorophenyl)-6,7- dimethoxy...
Synonyms:
CHEMBL540068, RTKI cpd, AG-E-19681, SureCN5477838, ANW-48170, ...
This record was replaced with 2051.
- Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-alpha bigenic mice. Lenferink, A.E., Simpson, J.F., Shawver, L.K., Coffey, R.J., Forbes, J.T., Arteaga, C.L. Proc. Natl. Acad. Sci. U.S.A. (2000)
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- Cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells. Correa-Meyer, E., Pesce, L., Guerrero, C., Sznajder, J.I. Am. J. Physiol. Lung Cell Mol. Physiol. (2002)
- Opposing effects of tyrosine kinase inhibitors on mineralization of normal and tumor bone cells. Klein, B.Y., Tepper, S.H., Gal, I., Shlomai, Z., Ben-Bassat, H. J. Cell. Biochem. (1997)
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- Inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes. Ben-Bassat, H., Rosenbaum-Mitrani, S., Hartzstark, Z., Shlomai, Z., Kleinberger-Doron, N., Gazit, A., Plowman, G., Levitzki, R., Tsvieli, R., Levitzki, A. Cancer Res. (1997)
- Tyrosine kinase inhibitors alter adhesivity of prostatic cancer cells to extracellular matrix components. Skogseth, H., Holt, R.U., Larsson, E., Halgunset, J. APMIS (2006)
- Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity. Busse, D., Doughty, R.S., Ramsey, T.T., Russell, W.E., Price, J.O., Flanagan, W.M., Shawver, L.K., Arteaga, C.L. J. Biol. Chem. (2000)
- Unliganded epidermal growth factor receptor dimerization induced by direct interaction of quinazolines with the ATP binding site. Arteaga, C.L., Ramsey, T.T., Shawver, L.K., Guyer, C.A. J. Biol. Chem. (1997)
- Interaction between protein tyrosine phosphatase and protein tyrosine kinase is involved in androgen-promoted growth of human prostate cancer cells. Meng, T.C., Lee, M.S., Lin, M.F. Oncogene (2000)
- Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle. Ivanov, A., Gerzanich, V., Ivanova, S., Denhaese, R., Tsymbalyuk, O., Simard, J.M. J. Physiol. (Lond.) (2006)
- Cholinergic agonists transactivate EGFR and stimulate MAPK to induce goblet cell secretion. Kanno, H., Horikawa, Y., Hodges, R.R., Zoukhri, D., Shatos, M.A., Rios, J.D., Dartt, D.A. Am. J. Physiol., Cell Physiol. (2003)
- Transcription levels of invasion-related genes in prostate cancer cells are modified by inhibitors of tyrosine kinase. Skogseth, H., Follestad, T., Larsson, E., Halgunset, J. APMIS (2006)
- Epidermal growth factor induces p11 gene and protein expression and down-regulates calcium ionophore-induced arachidonic acid release in human epithelial cells. Huang, X.L., Pawliczak, R., Cowan, M.J., Gladwin, M.T., Madara, P., Logun, C., Shelhamer, J.H. J. Biol. Chem. (2002)
- Antagonistic and agonistic effects of quinazoline tyrosine kinase inhibitors on mutant EGF receptor function. Montgomery, R.B. Int. J. Cancer (2002)
- Mechanical stretch stimulates growth of vascular smooth muscle cells via epidermal growth factor receptor. Iwasaki, H., Eguchi, S., Ueno, H., Marumo, F., Hirata, Y. Am. J. Physiol. Heart Circ. Physiol. (2000)
- PGE2-induced hypertrophy of cardiac myocytes involves EP4 receptor-dependent activation of p42/44 MAPK and EGFR transactivation. Mendez, M., LaPointe, M.C. Am. J. Physiol. Heart Circ. Physiol. (2005)
- Pseudomonas Lipopolysaccharide Accelerates Wound Repair via Activation of a Novel Epithelial Cell Signaling Cascade. Koff, J.L., Shao, M.X., Kim, S., Ueki, I.F., Nadel, J.A. J. Immunol. (2006)
- Inhibition of the epidermal growth factor receptor suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma cells. Budiyanto, A., Bito, T., Kunisada, M., Ashida, M., Ichihashi, M., Ueda, M. J. Invest. Dermatol. (2003)
- Signal transduction of MEK/ERK and PI3K/Akt activation by hypoxia/reoxygenation in renal epithelial cells. Kwon, D.S., Kwon, C.H., Kim, J.H., Woo, J.S., Jung, J.S., Kim, Y.K. Eur. J. Cell Biol. (2006)
- Endothelin-1 activates mesangial cell ERK1/2 via EGF-receptor transactivation and caveolin-1 interaction. Hua, H., Munk, S., Whiteside, C.I. Am. J. Physiol. Renal Physiol. (2003)
- Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase. Ellis, A.G., Doherty, M.M., Walker, F., Weinstock, J., Nerrie, M., Vitali, A., Murphy, R., Johns, T.G., Scott, A.M., Levitzki, A., McLachlan, G., Webster, L.K., Burgess, A.W., Nice, E.C. Biochem. Pharmacol. (2006)
- Direct inhibition of the cloned Kv1.5 channel by AG-1478, a tyrosine kinase inhibitor. Choi, B.H., Choi, J.S., Rhie, D.J., Yoon, S.H., Min, d.o. .S., Jo, Y.H., Kim, M.S., Hahn, S.J. Am. J. Physiol., Cell Physiol. (2002)
- Preferential inhibition of glioblastoma cells with wild-type epidermal growth factor receptors by a novel tyrosine kinase inhibitor ethyl-2,5-dihydroxycinnamate. Han, Y., Caday, C.G., Umezawa, K., Nanda, A. Oncol. Res. (1997)