Disease relevance of STAT1

• As for oxygen metabolism, oxygen consumption during hypothermia was significantly higher in alpha stat animals [1].
• The rate of reaction of various commercial lipases (porcine pancreas, Mucor miehei, Candida rugosa, Pseudomonas cepacia) as well as lipases from laboratory isolates-Bacillus stearothermophilus and Burkholderia cepacia RGP-10 for triolein hydrolysis was 7- to 12-fold higher in a microwave oven as compared to that by pH stat [2].

High impact information on STAT1

• Leptin (>/=1 nM) caused an increase in the activity of mitogen-activated protein kinases (MAPKs) that was accompanied by increased phosphorylation of STAT-3 and -5, but not STAT-1 [3].
• Leptin's effects are mediated by its receptors, which function as activators of a Janus family of tyrosine kinases-signal transducer and activator of transcription (JAK-STAT) pathway [3].
• Leptin is a weight-reducing hormone produced by adipose tissue, which reduces food intake via hypothalamic leptin receptors and the JAK-STAT signaling pathway [4].
• Intrahepatic synthesis of tumor necrosis factor-alpha related to cardiac surgery is inhibited by interleukin-10 via the Janus kinase (Jak)/signal transducers and activator of transcription (STAT) pathway [5].
• In addition, although these cytokines increase phosphorylation of signal transduction proteins in the JAK/STAT pathway, it appears that a different signal transduction pathway regulated by a combination of phosphatase activity and cAMP levels, leads to proplatelet formation [6].

Anatomical context of STAT1

• Long-term hypothermia with spontaneous circulation revealed significant differences in oxygen metabolism and pulmonary artery pressure as well as resistance between alpha and pH stat acid-base management [1].

Associations of STAT1 with chemical compounds

• Basal and bethanechol-stimulated secretion were measured by a pH stat device using 5 mM HCl [7].
• The whole body lactate during early rewarming was significantly less with the pH stat strategy [8].

Analytical, diagnostic and therapeutic context of STAT1

• During the first 10 minutes of rewarming, the cerebral microvascular diameter was significantly larger when the pH stat strategy was used [8].

References