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Gene Review

LOC396821  -  inducible nitric-oxide synthase

Sus scrofa

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Disease relevance of LOC396821


High impact information on LOC396821


Chemical compound and disease context of LOC396821


Biological context of LOC396821

  • Previously, we have shown that hypoxia results in increased generation of nitric oxide free radicals in the cerebral cortex of newborn piglets that may be due to up-regulation of nitric oxide synthases, neuronal nitric oxide synthase and inducible nitric oxide synthase [4].
  • RESULTS : During and after cardiac surgery, animals subjected to hypothermia exhibited lower expression of TNF-alpha and cyclo-oxygenase-2 but not of inducible nitric oxide synthase [7].

Anatomical context of LOC396821


Associations of LOC396821 with chemical compounds

  • RESULTS: In all of seven specimens from children with increased levels of nitrate/nitrite in the urine, we detected antibodies to iNOS, whereas in five of six control specimens--that is, from children with normal nitrate/nitrite levels--we could not detect any iNOS [2].
  • Nitric oxide is produced from the amino acid L-arginine by nitric oxide synthase, which has three known isoforms: (1) endothelial nitric oxide synthase and (2) brain nitric oxide synthase, both of which are constitutive nitric oxide synthase; and (3) inducible nitric oxide synthase [3].
  • To clarify the role of inducible nitric oxide synthase (iNOS) in the relaxation of nasal vasculature, the effects of a potent selective iNOS inhibitor, N-[(3-aminomethyl)benzyl]acetamidine (1400W), on histamine- and leukotriene D4 (LTD4)-induced relaxations of isolated nasal septal mucosae were examined in naive guinea pigs [8].
  • Despite differing effects on neutrophilia, these findings clearly indicate that neither DEX nor iNOS inhibition had any direct effect on LPS-induced cough hyporesponsiveness [9].
  • Analysis included two housekeeping genes, GAPDH and 18S, as well as three mediators of the glutamate pathway, glutamate aspartate transporter, glutamate synthetase, and inducible nitric oxide synthase [10].

Analytical, diagnostic and therapeutic context of LOC396821


  1. Hemorrhagic shock in swine: nitric oxide and potassium sensitive adenosine triphosphate channel activation. Musser, J.B., Bentley, T.B., Griffith, S., Sharma, P., Karaian, J.E., Mongan, P.D. Anesthesiology (2004) [Pubmed]
  2. Children with celiac disease express inducible nitric oxide synthase in the small intestine during gluten challenge. Holmgren Peterson, K., Fälth-Magnusson, K., Magnusson, K.E., Stenhammar, L., Sundqvist, T. Scand. J. Gastroenterol. (1998) [Pubmed]
  3. Presence and activity of nitric oxide synthase isoforms in ischemia-reperfusion-injured flaps. Khiabani, K.T., Kerrigan, C.L. Plast. Reconstr. Surg. (2002) [Pubmed]
  4. Nitric oxide-mediated mechanism of neuronal nitric oxide synthase and inducible nitric oxide synthase expression during hypoxia in the cerebral cortex of newborn piglets. Mishra, O.P., Mishra, R., Ashraf, Q.M., Delivoria-Papadopoulos, M. Neuroscience (2006) [Pubmed]
  5. Efficient inhibition of intimal hyperplasia by adenovirus-mediated inducible nitric oxide synthase gene transfer to rats and pigs in vivo. Shears, L.L., Kibbe, M.R., Murdock, A.D., Billiar, T.R., Lizonova, A., Kovesdi, I., Watkins, S.C., Tzeng, E. J. Am. Coll. Surg. (1998) [Pubmed]
  6. Regulation of Inducible Nitric Oxide Synthase Expression by Viral A238L-Mediated Inhibition of p65/RelA Acetylation and p300 Transactivation. Granja, A.G., Sabina, P., Salas, M.L., Fresno, M., Revilla, Y. J. Virol. (2006) [Pubmed]
  7. The use of moderate hypothermia during cardiac surgery is associated with repression of tumour necrosis factor-alpha via inhibition of activating protein-1: an experimental study. Qing, M., Wöltje, M., Schumacher, K., Sokalska, M., Vazquez-Jimenez, J.F., Minkenberg, R., Seghaye, M.C. Critical care (London, England) (2006) [Pubmed]
  8. Effects of 1400W, a potent selective inducible NOS inhibitor, on histamine- and leukotriene D4-induced relaxation of isolated guinea pig nasal mucosa. Chiba, Y., Matsuo, K., Sakai, H., Abe, K., Misawa, M. Nitric Oxide (2006) [Pubmed]
  9. Modulation of citric acid-induced cough following lipopolysaccharide-mediated neutrophilia in the guinea pig. Brown, C., Selig, W.M., Ellis, J.L. Pulmonary pharmacology & therapeutics (2007) [Pubmed]
  10. Optimization of ribonucleic Acid detection from archival Guinea pig temporal bone specimens. Hall, K.L., Pitts, D.R., Anne, S., Semaan, M.T., Alagramam, K.N., Megerian, C.A. Otol. Neurotol. (2007) [Pubmed]
  11. Role of inducible nitric oxide synthase on hepatic ischemia and reperfusion injury. Isobe, M., Katsuramaki, T., Kimura, H., Nagayama, M., Matsuno, T., Yagihashi, A., Hirata, K. Transplant. Proc. (2000) [Pubmed]
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