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Gene Review

NOS3  -  nitric oxide synthase 3 (endothelial cell)

Sus scrofa

Synonyms: EC-NOS, NOSIII, cNOS, eNOS
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Disease relevance of NOS3

  • After balloon injury of the left anterior descending (LAD) coronary artery, animals received an intramural injection of adenovirus (1.5 X 10(9) PFU) carrying either the NOS3 cDNA (AdCMVNOS3, n = 12), the PAI-1 cDNA (AdCMVPAI-1, n = 12), the TK cDNA (AdMLPItk, n = 12), or no cDNA (AdpL+, n = 12) [1].
  • We tested the hypothesis that hypoxia up-regulates endothelial nitric oxide synthase (NOS3, type III) protein expression in fetal hearts similar to that observed in adult hearts as a cardioprotective adaptation [2].
  • The development of NOS-3 dysfunction in resistance level PAs may contribute to the progression of chronic hypoxia-induced pulmonary hypertension in newborn piglets [3].
  • Our objective, therefore, was to determine whether cNOS, i.e. ecNOS (NOS-3) and nNOS (NOS-1) are still active in vessels of pigs treated with lipopolysaccharide (LPS) from Escherichia coli [4].

High impact information on NOS3


Anatomical context of NOS3


Associations of NOS3 with chemical compounds

  • A23187-induced alterations of APD and I(Ks) were strongly suppressed by a NOS3 inhibitor, but barely affected by a NOS1 inhibitor, suggesting that NOS3 was responsible for NO release in this phenomenon [10].
  • Analyses of RT-PCR and Western blotting showed that E2 did not increase NOS-3 expression [8].
  • A significant synthesis of NO by oocytes was observed in the presence of ionomycin, but not in the absence of ionomycin, indicating that oocyte NOS-3 functions in response to transient elevations in the intracellular calcium level [11].

Other interactions of NOS3

  • HPX decreased NOS3 protein levels in fetal guinea pig hearts by 29% after 28 days compared to NMX controls [2].

Analytical, diagnostic and therapeutic context of NOS3


  1. Percutaneous gene therapy using recombinant adenoviruses encoding human herpes simplex virus thymidine kinase, human PAI-1, and human NOS3 in balloon-injured porcine coronary arteries. Varenne, O., Sinnaeve, P., Gillijns, H., Iung, B., Laurysens, V., Meurrens, K., Bout, B., Valerio, D., Collen, D., Janssens, S.P., Gerard, R.D. Hum. Gene Ther. (2000) [Pubmed]
  2. Chronic hypoxia decreases endothelial nitric oxide synthase protein expression in fetal guinea pig hearts. Thompson, L.P., Dong, Y. J. Soc. Gynecol. Investig. (2005) [Pubmed]
  3. Impaired NO signaling in small pulmonary arteries of chronically hypoxic newborn piglets. Fike, C.D., Aschner, J.L., Zhang, Y., Kaplowitz, M.R. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  4. Regional changes in constitutive nitric oxide synthase and the hemodynamic consequences of its inhibition in lipopolysaccharide-treated pigs. Javeshghani, D., Magder, S. Shock (2001) [Pubmed]
  5. The effects of static and intermittent compression on nitric oxide production in articular cartilage explants. Fermor, B., Weinberg, J.B., Pisetsky, D.S., Misukonis, M.A., Banes, A.J., Guilak, F. J. Orthop. Res. (2001) [Pubmed]
  6. Nitric oxide synthase isoform expression in a porcine model of granulation tissue formation. Pollock, J.S., Webb, W., Callaway, D., Sathyanarayana, n.u.l.l., O'Brien, W., Howdieshell, T.R. Surgery (2001) [Pubmed]
  7. Oral pre-treatment with rosuvastatin protects porcine myocardium from ischaemia/reperfusion injury via a mechanism related to nitric oxide but not to serum cholesterol level. Bulhak, A.A., Gourine, A.V., Gonon, A.T., Sjöquist, P.O., Valen, G., Pernow, J. Acta Physiol. Scand. (2005) [Pubmed]
  8. Estrogen regulation of nitric oxide synthesis in the porcine oocyte. Hattori, M.A., Arai, M., Saruwatari, K., Kato, Y. Mol. Cell. Biochem. (2004) [Pubmed]
  9. L-N6-(1-iminoethyl)-lysine (L-NIL) but not S-methylisothiourea sulphate (SMT) displays selectivity towards NOS-2. Chłopicki, S., Olszanecki, R., Jakubowski, A., Lomnicka, M., Gryglewski, R.J. Polish journal of pharmacology. (1999) [Pubmed]
  10. Role of nitric oxide in Ca2+ sensitivity of the slowly activating delayed rectifier K+ current in cardiac myocytes. Bai, C.X., Namekata, I., Kurokawa, J., Tanaka, H., Shigenobu, K., Furukawa, T. Circ. Res. (2005) [Pubmed]
  11. Expression of nitric oxide synthase-3 in porcine oocytes obtained at different follicular development. Takesue, K., Tabata, S., Sato, F., Hattori, M.A. J. Reprod. Dev. (2003) [Pubmed]
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