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Gene Review

glnA  -  glutamine synthetase

Escherichia coli UTI89

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Disease relevance of glnA


High impact information on glnA


Chemical compound and disease context of glnA


Biological context of glnA

  • Polarity in the glnA operon: suppression of the reg- phenotype by rho mutations [9].
  • The result underscores the importance of proper regulation of GS activity for cell growth [3].
  • All of these results strongly imply that elevated GS activity is the causative basis for the poor growth seen in R. rubrum mutants lacking P(II) and presumably in mutants of some other organisms with similar genotypes [3].
  • Thus, the tight binding of ligands to the subunit active site strengthens both intra- and inter-subunit bonding domains in dodecameric glutamine synthetase [6].

Associations of glnA with chemical compounds


Analytical, diagnostic and therapeutic context of glnA


  1. Regulation of expression from the glnA promoter of Escherichia coli in the absence of glutamine synthetase. Rothstein, D.M., Pahel, G., Tyler, B., Magasanik, B. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  2. The ntr genes of Escherichia coli activate the hut and nif operons of Klebsiella pneumoniae. Tuli, R., Fisher, R., Haselkorn, R. Gene (1982) [Pubmed]
  3. The poor growth of Rhodospirillum rubrum mutants lacking PII proteins is due to an excess of glutamine synthetase activity. Zhang, Y., Pohlmann, E.L., Conrad, M.C., Roberts, G.P. Mol. Microbiol. (2006) [Pubmed]
  4. A cloned cyanobacterial gene for glutamine synthetase functions in Escherichia coli, but the enzyme is not adenylylated. Fisher, R., Tuli, R., Haselkorn, R. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  5. A new glnA-linked regulatory gene for glutamine synthetase in Escherichia coli. Pahel, G., Tyler, B. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  6. Active site ligand stabilization of quaternary structures of glutamine synthetase from Escherichia coli. Maurizi, M.R., Ginsburg, A. J. Biol. Chem. (1982) [Pubmed]
  7. Investigation of the functional properties and regulation of three glutamine synthetase-like genes in Streptomyces coelicolor A3(2). Rexer, H.U., Sch??berle, T., Wohlleben, W., Engels, A. Arch. Microbiol. (2006) [Pubmed]
  8. Ammonia assimilation and glutamate formation in Caulobacter crescentus. Ely, B., Amarasinghe, A.B., Bender, R.A. J. Bacteriol. (1978) [Pubmed]
  9. Polarity in the glnA operon: suppression of the reg- phenotype by rho mutations. Guterman, S.K., Roberts, G., Tyler, B. J. Bacteriol. (1982) [Pubmed]
  10. Fluorometric studies of aza-epsilon-adenylylated glutamine synthetase from Escherichia coli. Rhee, S.G., Ubom, G.A., Hunt, J.B., Chock, P.B. J. Biol. Chem. (1981) [Pubmed]
  11. Molecular analysis of two mutants from Lotus japonicus deficient in plastidic glutamine synthetase: functional properties of purified GLN2 enzymes. Betti, M., Arcondéguy, T., Márquez, A.J. Planta (2006) [Pubmed]
  12. Stereochemistry of binding of thiophosphate analogs of ATP and ADP to carbamate kinase, glutamine synthetase, and carbamoyl-phosphate synthetase. Pillai, R.P., Raushel, F.M., Villafranca, J.J. Arch. Biochem. Biophys. (1980) [Pubmed]
  13. Scanning transmission electron microscopy of submolecular oligomers of stabilized glutamine synthetase from Escherichia coli. Haschemeyer, R.H., Wall, J.S., Hainfeld, J., Maurizi, M.R. J. Biol. Chem. (1982) [Pubmed]
  14. Expression of the Bacillus subtilis glutamine synthetase gene in Escherichia coli. Gardner, A.L., Aronson, A.I. J. Bacteriol. (1984) [Pubmed]
  15. Relationship between epitope density and immunoprecipitation of multivalent antigens by bivalent antibody: immunoprecipitation of adenylylated glutamine synthetase by anti-AMP antibodies. Hohman, R.J., Stadtman, E.R. Arch. Biochem. Biophys. (1982) [Pubmed]
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