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Gene Review

MMP3  -  matrix metallopeptidase 3 (stromelysin 1,...

Canis lupus familiaris

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Disease relevance of MMP3


High impact information on MMP3

  • Neither secreted collagenases (MMP-1 and MMP-13), gelatinases (gelatinase A or B), stromelysins (MMP-3 and MMP-11), or matrilysin (MMP-7) affected SF/HGF-induced responses [5].
  • Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network [6].
  • Immobilisation did not affect the activity of PLA(2), or the concentration of MMP-3 or HA in synovial fluid [7].
  • Increases in synovial TIMP-1 in OA were less pronounced and the molar ratio of MMP-3/TIMP-1 remained far below 1.0, demonstrating a surplus of the protease inhibitor [8].
  • OBJECTIVE: To explore the levels of matrix metalloprotease-3 (MMP-3), tissue inhibitor of metalloproteases-1 (TIMP-1), 5D4 keratan sulfate, and two 3B3 chondroitin-sulfate epitopes in several canine osteoarthritic and inflammatory arthropathies [8].

Anatomical context of MMP3


Associations of MMP3 with chemical compounds

  • The levels in SF of chondroitin sulfate (CS), tissue inhibitor of metalloproteinases (TIMP-1), stromelysin (MMP-3), hyaluronan (HA), and the activity of phospholipase A2 enzyme (PLA2) were assayed [4].
  • Activities of IL-1beta, IL-6, TNF-alpha, and MMP-3 and S-GAG contents were measured [10].

Regulatory relationships of MMP3

  • In the present study, we examined necropsy samples of renal cortex from normal and XLAS dogs for MMP-3 and MMP-7 as they have the potential to activate MMP-2 and MMP-9 [1].

Other interactions of MMP3

  • The induction of these MMPs likely contributes to tissue destruction associated with the fibrogenic process, while augmenting the activation of MMP-2 and MMP-9 by MMP-3 and MMP-7 in XLAS [1].
  • With avidin-biotin immunohistochemistry, these specimens were stained with antibodies to IL-1 beta, TNF-alpha, MMP-3, fibronectin, and altered proteoglycan sulfate with the monoclonal antibody 3-B-3 [11].

Analytical, diagnostic and therapeutic context of MMP3

  • RT-PCR and casein zymography confirmed that both mRNA transcripts and activities of MMP-3 and MMP-7 are elevated in XLAS kidneys [1].
  • RESULTS: Median levels of synovial MMP-3, TIMP-1 and molar ratios of MMP/TIMP-1 were significantly higher in the arthritis than in the control group [8].
  • The molar ratio of MMP-3 to TIMP-1 was higher (p = 0.001) in group II than in group I. The changes observed in the concentration of synovial fluid markers in this slowly progressive canine OA model suggest that activation of an inflammation-related process occurs at an early stage of the OA disease induced by unilateral tibial valgus osteotomy [4].
  • The OA-MAT-MAG group did not differ from the normal left group in MMP-3 as determined by Western blot analysis [12].
  • Synovial fluid samples of 17 dogs with CRA were analysed for MMP-3 and TIMP-1 by two canine sandwich ELISA (enzyme-linked immunosorbent assay) systems [3].


  1. Dysregulation of renal MMP-3 and MMP-7 in canine X-linked Alport syndrome. Rao, V.H., Lees, G.E., Kashtan, C.E., Delimont, D.C., Singh, R., Meehan, D.T., Bhattacharya, G., Berridge, B.R., Cosgrove, D. Pediatr. Nephrol. (2005) [Pubmed]
  2. Immunohistochemical analysis of matrix metalloproteinase-1, -3, and -13 in naturally occurring cartilaginous tumors of dogs. Kuroki, K., Kreeger, J.M., Cook, J.L., Tomlinson, J.L., Johnson, G.C., Pace, L.W., Turnquist, S.E., Turk, J.R., Ramos, J.A., Miller, M.A. Am. J. Vet. Res. (2002) [Pubmed]
  3. Synovial MMP-3 and TIMP-1 levels and their correlation with cytokine expression in canine rheumatoid arthritis. Hegemann, N., Wondimu, A., Ullrich, K., Schmidt, M.F. Vet. Immunol. Immunopathol. (2003) [Pubmed]
  4. Elevated levels of synovial fluid PLA2, stromelysin (MMP-3) and TIMP in early osteoarthrosis after tibial valgus osteotomy in young beagle dogs. Panula, H.E., Lohmander, L.S., Rönkkö, S., Agren, U., Helminen, H.J., Kiviranta, I. Acta orthopaedica Scandinavica. (1998) [Pubmed]
  5. Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3. Hotary, K., Allen, E., Punturieri, A., Yana, I., Weiss, S.J. J. Cell Biol. (2000) [Pubmed]
  6. Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network. Kang, T., Nagase, H., Pei, D. Cancer Res. (2002) [Pubmed]
  7. Decline after immobilisation and recovery after remobilisation of synovial fluid IL1, TIMP, and chondroitin sulphate levels in young beagle dogs. Haapala, J., Arokoski, J.P., Rönkkö, S., Agren, U., Kosma, V.M., Lohmander, L.S., Tammi, M., Helminen, H.J., Kiviranta, I. Ann. Rheum. Dis. (2001) [Pubmed]
  8. Biomarkers of joint tissue metabolism in canine osteoarthritic and arthritic joint disorders. Hegemann, N., Kohn, B., Brunnberg, L., Schmidt, M.F. Osteoarthr. Cartil. (2002) [Pubmed]
  9. Proinflammatory cytokine activities, matrix metalloproteinase-3 activity, and sulfated glycosaminoglycan content in synovial fluid of dogs with naturally acquired cranial cruciate ligament rupture. Fujita, Y., Hara, Y., Nezu, Y., Schulz, K.S., Tagawa, M. Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons. (2006) [Pubmed]
  10. Direct and indirect markers of cartilage metabolism in synovial fluid obtained from dogs with hip dysplasia and correlation with clinical and radiographic variables. Fujita, Y., Hara, Y., Nezu, Y., Yamaguchi, S., Schulz, K.S., Tagawa, M. Am. J. Vet. Res. (2005) [Pubmed]
  11. Immunolocalization of selected cytokines and proteases in canine articular cartilage after transarticular loading. Pickvance, E.A., Oegema, T.R., Thompson, R.C. J. Orthop. Res. (1993) [Pubmed]
  12. Use of a permanent magnetic field to inhibit the development of canine osteoarthritis. Rogachefsky, R.A., Altman, R.D., Markov, M.S., Cheung, H.S. Bioelectromagnetics. (2004) [Pubmed]
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