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Gene Review

alpha-Cat  -  alpha Catenin

Drosophila melanogaster

Synonyms: CG17947, CT39986, Catenin alpha, Dalpha-Cat, Dalpha-cat, ...
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High impact information on alpha-Cat


Biological context of alpha-Cat


Anatomical context of alpha-Cat

  • Here we show interactions between Drosophila Rho1 and the adherens junction components alpha-catenin and p120(ctn) [10].
  • Genes such as egalitarian, Bicaudal D, stonewall, and encore are important for oocyte determination, while differential adhesion between the oocyte and its surrounding prefollicle cells, as mediated by armadillo, alpha-catenin, shotgun, and the spindle genes, is crucial for oocyte translocation [11].
  • In this study, we constructed Dalpha-catenin fused with a green fluorescent protein (Dalpha-catenin-GFP), and found that it targeted apically located AJ-based contacts but not other lateral contacts in epithelial cells of living Drosophila embryos [12].
  • Roles of Armadillo, a Drosophila catenin, during central nervous system development [13].
  • Using Xenopus embryos we show by expression of murine p120cas1B (mp120cas1B) in ventral blastomeres that this catenin cannot replace beta-catenin function in dorsal axis formation [14].

Associations of alpha-Cat with chemical compounds


Physical interactions of alpha-Cat

  • The alpha-catenin binding site is fully encoded within exon 3 of plakoglobin but only partially represented in Armadillo repeat 1 [7].

Other interactions of alpha-Cat

  • Therefore, we utilized the two hybrid system and confirmatory co-immunoprecipitations to identify a novel catenin, termed gamma-catenin, which interacts with PS1 and is principally expressed in brain [17].

Analytical, diagnostic and therapeutic context of alpha-Cat


  1. shotgun encodes Drosophila E-cadherin and is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia. Tepass, U., Gruszynski-DeFeo, E., Haag, T.A., Omatyar, L., Török, T., Hartenstein, V. Genes Dev. (1996) [Pubmed]
  2. Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. Myster, S.H., Cavallo, R., Anderson, C.T., Fox, D.T., Peifer, M. J. Cell Biol. (2003) [Pubmed]
  3. Abelson kinase regulates epithelial morphogenesis in Drosophila. Grevengoed, E.E., Loureiro, J.J., Jesse, T.L., Peifer, M. J. Cell Biol. (2001) [Pubmed]
  4. Regulated expression of nullo is required for the formation of distinct apical and basal adherens junctions in the Drosophila blastoderm. Hunter, C., Wieschaus, E. J. Cell Biol. (2000) [Pubmed]
  5. Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling. Funayama, N., Fagotto, F., McCrea, P., Gumbiner, B.M. J. Cell Biol. (1995) [Pubmed]
  6. An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling. Orsulic, S., Peifer, M. J. Cell Biol. (1996) [Pubmed]
  7. Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin. Aberle, H., Schwartz, H., Hoschuetzky, H., Kemler, R. J. Biol. Chem. (1996) [Pubmed]
  8. The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Daniel, J.M., Reynolds, A.B. Mol. Cell. Biol. (1999) [Pubmed]
  9. Localizing the adhesive and signaling functions of plakoglobin. Rubenstein, A., Merriam, J., Klymkowsky, M.W. Dev. Genet. (1997) [Pubmed]
  10. Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila. Magie, C.R., Pinto-Santini, D., Parkhurst, S.M. Development (2002) [Pubmed]
  11. Asymmetric germ cell division and oocyte determination during Drosophila oogenesis. Deng, W., Lin, H. Int. Rev. Cytol. (2001) [Pubmed]
  12. Dynamic features of adherens junctions during Drosophila embryonic epithelial morphogenesis revealed by a Dalpha-catenin-GFP fusion protein. Oda, H., Tsukita, S. Dev. Genes Evol. (1999) [Pubmed]
  13. Roles of Armadillo, a Drosophila catenin, during central nervous system development. Loureiro, J., Peifer, M. Curr. Biol. (1998) [Pubmed]
  14. Expression of the Armadillo family member p120cas1B in Xenopus embryos affects head differentiation but not axis formation. Geis, K., Aberle, H., Kühl, M., Kemler, R., Wedlich, D. Dev. Genes Evol. (1998) [Pubmed]
  15. A Drosophila homolog of cadherin associated with armadillo and essential for embryonic cell-cell adhesion. Oda, H., Uemura, T., Harada, Y., Iwai, Y., Takeichi, M. Dev. Biol. (1994) [Pubmed]
  16. Regulation of cell adhesion in the Drosophila embryo by phosphorylation of the Cadherin-Catenin-Complex. Wang, F., Hartenstein, V. Cell Tissue Res. (2006) [Pubmed]
  17. Presenilin 1 interaction in the brain with a novel member of the Armadillo family. Zhou, J., Liyanage, U., Medina, M., Ho, C., Simmons, A.D., Lovett, M., Kosik, K.S. Neuroreport (1997) [Pubmed]
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