Gene Review:
MXD1 - MAX dimerization protein 1
Homo sapiens
Synonyms:
BHLHC58, MAD, MAD1, Max dimerization protein 1, Max dimerizer 1, ...
- Mad proteins contain a dominant transcription repression domain. Ayer, D.E., Laherty, C.D., Lawrence, Q.A., Armstrong, A.P., Eisenman, R.N. Mol. Cell. Biol. (1996)
- Mad-overexpression down regulates the malignant growth and p53 mediated apoptosis in human hepatocellular carcinoma BEL-7404 cells. Zhao, H., Xu, Y.H. Cell Res. (1999)
- Effect of the transcriptional repressor Mad1 on proliferation of human melanoma cells. Ohta, Y., Hamada, Y., Saitoh, N., Katsuoka, K. Exp. Dermatol. (2002)
- Expression of Mad1 protein inhibits proliferation of cancer cells and inversely correlated with Myc protein expression in primary gastric cancer. Han, S., Park, K., Kim, H.Y., Lee, M.S., Kim, H.J., Kim, Y.D. Oncol. Rep. (1999)
- The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells. Phanish, M.K., Wahab, N.A., Colville-Nash, P., Hendry, B.M., Dockrell, M.E. Biochem. J. (2006)
- MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation. Poortinga, G., Hannan, K.M., Snelling, H., Walkley, C.R., Jenkins, A., Sharkey, K., Wall, M., Brandenburger, Y., Palatsides, M., Pearson, R.B., McArthur, G.A., Hannan, R.D. EMBO J. (2004)
- Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation. Foley, K.P., McArthur, G.A., Quéva, C., Hurlin, P.J., Soriano, P., Eisenman, R.N. EMBO J. (1998)
- Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts. Berg, T., Cohen, S.B., Desharnais, J., Sonderegger, C., Maslyar, D.J., Goldberg, J., Boger, D.L., Vogt, P.K. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Xu, D., Popov, N., Hou, M., Wang, Q., Björkholm, M., Gruber, A., Menkel, A.R., Henriksson, M. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Opposite regulation of gene transcription and cell proliferation by c-Myc and Max. Gu, W., Cechova, K., Tassi, V., Dalla-Favera, R. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Mad1 expression in the absence of differentiation: effect of cAMP on the B-lymphoid cell line Reh. Naderi, S., Blomhoff, H.K. J. Cell. Physiol. (1999)
- Analysis of E-box DNA binding during myeloid differentiation reveals complexes that contain Mad but not Max. Ryan, K.M., Birnie, G.D. Biochem. J. (1997)
- Loss of Sin3/Rpd3 histone deacetylase restores the DNA damage response in checkpoint-deficient strains of Saccharomyces cerevisiae. Scott, K.L., Plon, S.E. Mol. Cell. Biol. (2003)
- The Mad1 transcription factor is a novel target of activin and TGF-beta action in keratinocytes: possible role of Mad1 in wound repair and psoriasis. Werner, S., Beer, H.D., Mauch, C., Lüscher, B., Werner, S. Oncogene (2001)
- Contrasting localization of c-Myc with other Myc superfamily transcription factors in the human hair follicle and during the hair growth cycle. Bull, J.J., Müller-Röver, S., Patel, S.V., Chronnell, C.M., McKay, I.A., Philpott, M.P. J. Invest. Dermatol. (2001)
- Novel expression patterns of the myc/max/mad transcription factor network in developing murine prostate gland. Luo, Q., Harmon, E., Timms, B.G., Kretzner, L. J. Urol. (2001)
- Co-induction of Mad1 and c-Myc in activated normal B lymphocytes. Ertesvåg, A., Blomhoff, H.K., Beiske, K., Naderi, S. Scand. J. Immunol. (2000)
- Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells. Cong, Y.S., Bacchetti, S. J. Biol. Chem. (2000)
- Toward the elucidation of the structural determinants responsible for the molecular recognition between Mad1 and Max. Montagne, M., Naud, J.F., McDuff, F.O., Lavigne, P. Biochemistry (2005)
- Enhancing the antiproliferative effect of topoisomerase II inhibitors using a polypeptide inhibitor of c-Myc. Bidwell, G.L., Raucher, D. Biochem. Pharmacol. (2006)
- Identification and characterization of specific DNA-binding complexes containing members of the Myc/Max/Mad network of transcriptional regulators. Sommer, A., Bousset, K., Kremmer, E., Austen, M., Lüscher, B. J. Biol. Chem. (1998)
- Inhibition of proliferation and apoptosis by the transcriptional repressor Mad1. Repression of Fas-induced caspase-8 activation. Gehring, S., Rottmann, S., Menkel, A.R., Mertsching, J., Krippner-Heidenreich, A., Lüscher, B. J. Biol. Chem. (2000)
- Silencing of the Epstein-Barr virus latent membrane protein 1 gene by the Max-Mad1-mSin3A modulator of chromatin structure. Sjöblom-Hallén, A., Yang, W., Jansson, A., Rymo, L. J. Virol. (1999)