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ME2  -  malic enzyme 2, NAD(+)-dependent,...

Homo sapiens

Synonyms: Malic enzyme 2, NAD-ME, NAD-dependent malic enzyme, mitochondrial
 
 
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Disease relevance of ME2

 

High impact information on ME2

 

Biological context of ME2

 

Anatomical context of ME2

 

Associations of ME2 with chemical compounds

  • Three genomic clones form the C4 species Flaveria bidentis were characterized and found to encode two highly similar chloroplastic forms of NADP-malic enzyme, termed ME1 and ME2 [9].
  • The two RIPs, named ME1 and ME2, were purified to homogeneity by ammonium sulfate precipitation, cation-exchange perfusion chromatography, and C4 reverse-phase chromatography [1].
  • This technology was made by 10 parts of mannitol and 1 part of ME2 with about 6 microm in average particle size [10].
 

Other interactions of ME2

  • Depurination of yeast 26S rRNA by ME1 and ME2 demonstrated their ribosome-inactivating activity [1].
 

Analytical, diagnostic and therapeutic context of ME2

  • Amino acid composition and western-blot analysis further suggested a structural similarity between ME1 and ME2 [1].

References

  1. Characterization of two novel type I ribosome-inactivating proteins from the storage roots of the andean crop Mirabilis expansa. Vivanco, J.M., Savary, B.J., Flores, H.E. Plant Physiol. (1999) [Pubmed]
  2. Monoclonal antibodies against mesothelial membrane antigen discriminate between malignant mesothelioma and lung adenocarcinoma. Stahel, R.A., O'Hara, C.J., Waibel, R., Martin, A. Int. J. Cancer (1988) [Pubmed]
  3. A comparison of immunohistochemical staining of human cultured mesothelial cells and ovarian tumour cells using epithelial and mesothelial cell markers. Radford, H., Wilson, A.P. Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology. (1996) [Pubmed]
  4. Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis. Wright, W.C., Daniels, W.P., Fogh, J. J. Natl. Cancer Inst. (1981) [Pubmed]
  5. Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy. Greenberg, D.A., Cayanis, E., Strug, L., Marathe, S., Durner, M., Pal, D.K., Alvin, G.B., Klotz, I., Dicker, E., Shinnar, S., Bromfield, E.B., Resor, S., Cohen, J., Moshe, S.L., Harden, C., Kang, H. Am. J. Hum. Genet. (2005) [Pubmed]
  6. NAD malic enzyme and the control of carbohydrate metabolism in potato tubers. Jenner, H.L., Winning, B.M., Millar, A.H., Tomlinson, K.L., Leaver, C.J., Hill, S.A. Plant Physiol. (2001) [Pubmed]
  7. Genetics of idiopathic generalized epilepsies. Gardiner, M. Epilepsia (2005) [Pubmed]
  8. A population study of leukocyte enzymes (GOT2, ME2 and PGM3) in Galicia (NW Spain). Llano, C., Caeiro, J.L., Boán, F. Hum. Hered. (1990) [Pubmed]
  9. Two genes encode highly similar chloroplastic NADP-malic enzymes in Flaveria. Implications for the evolution of C4 photosynthesis. Marshall, J.S., Stubbs, J.D., Taylor, W.C. Plant Physiol. (1996) [Pubmed]
  10. Physicochemical characterization of meloxicam-mannitol binary systems. Nassab, P.R., Rajkó, R., Szabó-Révész, P. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
 
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