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Gene Review

Aldoa  -  aldolase A, fructose-bisphosphate

Rattus norvegicus

Synonyms: Aldo1, Fructose-bisphosphate aldolase A, Muscle-type aldolase, RNALDOG5
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Disease relevance of Aldoa


High impact information on Aldoa


Biological context of Aldoa


Anatomical context of Aldoa


Associations of Aldoa with chemical compounds


Other interactions of Aldoa


Analytical, diagnostic and therapeutic context of Aldoa

  • The changes of aldolase mRNA levels were analyzed further by northern blot and dot-blot hybridization experiments using cloned aldolase A and B cDNAs [14].
  • The band was identified by mass spectrometry to be aldolase A. Western blotting with aldolase using patient sera demonstrated a band of identical size [24].
  • Their epitopes were mapped in detail on the molecule by examining the reactivities of the MAbs to chimeric proteins between aldolases A and B [Kitajima et al. (1990) J. Biol. Chem. 265, 17493-17498] in ELISA and to the CNBr-cleaved fragments of aldolase A in immuno-blotting [25].
  • RNA was isolated and mRNA levels of the HIF-1 dependent genes aldolase A and vascular endothelial growth factor (VEGF) were determined using quantitative real-time RT-PCR [26].
  • Although hepatic microvascular perfusion was comparable in saline- and LPS-treated rats, hepatic microvascular blood flow and aldolase A expression were significantly inversely correlated among endotoxemic rats (r = 0.773; P = 0.003) [26].


  1. Tissue-specific expression of rat aldolase A mRNAs. Three molecular species differing only in the 5'-terminal sequences. Mukai, T., Joh, K., Arai, Y., Yatsuki, H., Hori, K. J. Biol. Chem. (1986) [Pubmed]
  2. Aldosterone and dexamethasone both stimulate energy acquisition whereas only the glucocorticoid alters energy storage. Santana, P., Akana, S.F., Hanson, E.S., Strack, A.M., Sebastian, R.J., Dallman, M.F. Endocrinology (1995) [Pubmed]
  3. Synthesis in vitro of aldolase A by polysomes or mRNA of rat ascites hepatoma AH 7974 cells. Sakiyama, S., Yoda, K., Fujimura, S. Biochem. Biophys. Res. Commun. (1976) [Pubmed]
  4. Expression of aldolase A messenger RNAs in human adult and foetal tissues and in hepatoma. Mennecier, F., Daegelen, D., Schweighoffer, F., Levin, M., Kahn, A. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  5. The MEF-3 motif is required for MEF-2-mediated skeletal muscle-specific induction of the rat aldolase A gene. Hidaka, K., Yamamoto, I., Arai, Y., Mukai, T. Mol. Cell. Biol. (1993) [Pubmed]
  6. Growth in culture and tumorigenicity after transfection with the ras oncogene of liver epithelial cells from carcinogen-treated rats. Braun, L., Goyette, M., Yaswen, P., Thompson, N.L., Fausto, N. Cancer Res. (1987) [Pubmed]
  7. Isozyme profiles of oval cells, parenchymal cells, and biliary cells isolated by centrifugal elutriation from normal and preneoplastic livers. Hayner, N.T., Braun, L., Yaswen, P., Brooks, M., Fausto, N. Cancer Res. (1984) [Pubmed]
  8. Nonconservative utilization of aldolase A alternative promoters. Stauffer, J.K., Colbert, M.C., Ciejek-Baez, E. J. Biol. Chem. (1990) [Pubmed]
  9. Expression of three mRNA species from a single rat aldolase A gene, differing in their 5' non-coding regions. Joh, K., Arai, Y., Mukai, T., Hori, K. J. Mol. Biol. (1986) [Pubmed]
  10. Analysis of upstream regulatory regions required for the activities of two promoters of the rat aldolase A gene. Joh, K., Takano, K., Mukai, T., Hori, K. FEBS Lett. (1991) [Pubmed]
  11. Two different aldolase A mRNA species in rat tissues. Tsutsumi, R., Tsutsumi, K., Numazaki, M., Ishikawa, K. Eur. J. Biochem. (1984) [Pubmed]
  12. Molecular cloning and expression of rat aldolase C messenger RNA during development and hepatocarcinogenesis. Skala, H., Vibert, M., Lamas, E., Maire, P., Schweighoffer, F., Kahn, A. Eur. J. Biochem. (1987) [Pubmed]
  13. Mode of interactions of human aldolase isozymes with cytoskeletons. Kusakabe, T., Motoki, K., Hori, K. Arch. Biochem. Biophys. (1997) [Pubmed]
  14. Expression of aldolase isozyme mRNAs in fetal rat liver. Numazaki, M., Tsutsumi, K., Tsutsumi, R., Ishikawa, K. Eur. J. Biochem. (1984) [Pubmed]
  15. Transcriptional regulation of an aldolase gene in the regenerating rat liver. Motomura, M., Mukai, T., Ozaki, I., Joh, K., Arai, Y., Sakai, T., Hori, K. Gastroenterol. Jpn. (1990) [Pubmed]
  16. Aspects of regulation in kidney at the enzymic level: aldolase isozymes, aminopeptidase and alkaline phosphatase. Wachsmuth, E.D. Current problems in clinical biochemistry. (1976) [Pubmed]
  17. In vivo developmental modifications of the expression of genes encoding muscle-specific enzymes in rat. Schweighoffer, F., Maire, P., Tuil, D., Gautron, S., Daegelen, D., Bachner, L., Kahn, A. J. Biol. Chem. (1986) [Pubmed]
  18. Lithium regulation of aldolase A expression in the rat frontal cortex: identification by differential display. Hua, L.V., Green, M., Warsh, J.J., Li, P.P. Biol. Psychiatry (2000) [Pubmed]
  19. Improved cardiac contractile functions in hypoxia-reoxygenation in rats treated with low concentration Co(2+). Endoh, H., Kaneko, T., Nakamura, H., Doi, K., Takahashi, E. Am. J. Physiol. Heart Circ. Physiol. (2000) [Pubmed]
  20. Rat aldolase A messenger RNA: the nucleotide sequence and multiple mRNA species with different 5'-terminal regions. Joh, K., Mukai, T., Yatsuki, H., Hori, K. Gene (1985) [Pubmed]
  21. The structure of the brain-specific rat aldolase C gene and its regional expression. Mukai, T., Yatsuki, H., Masuko, S., Arai, Y., Joh, K., Hori, K. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  22. Differential activation of some transcription factors during rat liver ischemia, reperfusion, and heat shock. Tacchini, L., Radice, L., Bernelli-Zazzera, A. J. Cell. Physiol. (1999) [Pubmed]
  23. Cytokines induce HIF-1 DNA binding and the expression of HIF-1-dependent genes in cultured rat enterocytes. Scharte, M., Han, X., Bertges, D.J., Fink, M.P., Delude, R.L. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  24. Identification of aldolase as a target antigen in Alzheimer's disease. Mor, F., Izak, M., Cohen, I.R. J. Immunol. (2005) [Pubmed]
  25. Monoclonal antibodies recognizing amino-terminal and carboxy-terminal regions of human aldolase A: probes to detect conformational changes of the enzyme. Kitajima, Y., Matsuhashi, S., Nishida, H., Takasaki, Y., Takahashi, I., Hisatsugu, T., Hori, K. J. Biochem. (1991) [Pubmed]
  26. LPS Increases Hepatic HIF-1alpha Protein and Expression of the HIF-1-Dependent Gene Aldolase A in Rats. Scharte, M., Han, X., Uchiyama, T., Tawadrous, Z., Delude, R.L., Fink, M.P. J. Surg. Res. (2006) [Pubmed]
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