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Gene Review

Jon99Cii  -  Jonah 99Cii

Drosophila melanogaster

Synonyms: 99Calpha, CG31034, CG7877, Dmel\CG31034, Jon99B, ...
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Disease relevance of Jon99Cii


High impact information on Jon99Cii


Biological context of Jon99Cii


Anatomical context of Jon99Cii

  • We identified five new serine protease cDNAs from the hemolymph of the malaria vector, Anopheles gambiae [10].
  • Recent studies have demonstrated that the zymogen form of the serine protease factor C, a major granular component of hemocyte, also exists on the hemocyte surface and functions as a biosensor for LPS [11].

Associations of Jon99Cii with chemical compounds

  • Partial clones of thirty-eight distinct serine protease encoding sequences were isolated, and nineteen different full-length cDNAs encoding mature serine proteases were subsequently cloned and sequenced [12].
  • Anosmin-1 is an extracellular protein which contains a cysteine-rich region, a whey acidic protein (WAP) domain homologous to some serine protease inhibitors, and four fibronectin-like type III (FnIII) repeats [13].

Analytical, diagnostic and therapeutic context of Jon99Cii

  • Comparison of the restriction fragment patterns of PCR products generated from the three different sources suggests a highly diverse tissue-specific pattern of serine protease expression in this organism [9].


  1. Wolbachia endosymbionts of Onchocerca volvulus express a putative periplasmic HtrA-type serine protease. Jolodar, A., Fischer, P., Büttner, D.W., Brattig, N.W. Microbes Infect. (2004) [Pubmed]
  2. Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling. Weber, A.N., Tauszig-Delamasure, S., Hoffmann, J.A., Lelièvre, E., Gascan, H., Ray, K.P., Morse, M.A., Imler, J.L., Gay, N.J. Nat. Immunol. (2003) [Pubmed]
  3. The Drosophila Stubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesis. Appel, L.F., Prout, M., Abu-Shumays, R., Hammonds, A., Garbe, J.C., Fristrom, D., Fristrom, J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. Recombinant prolylcarboxypeptidase activates plasma prekallikrein. Shariat-Madar, Z., Mahdi, F., Schmaier, A.H. Blood (2004) [Pubmed]
  5. Levels of RNA from a family of putative serine protease genes are reduced in Drosophila melanogaster dunce mutants and are regulated by cyclic AMP. Yun, Y., Davis, R.L. Mol. Cell. Biol. (1989) [Pubmed]
  6. Comparative analysis of serine protease-related genes in the honey bee genome: possible involvement in embryonic development and innate immunity. Zou, Z., Lopez, D.L., Kanost, M.R., Evans, J.D., Jiang, H. Insect Mol. Biol. (2006) [Pubmed]
  7. A serpin regulates dorsal-ventral axis formation in the Drosophila embryo. Ligoxygakis, P., Roth, S., Reichhart, J.M. Curr. Biol. (2003) [Pubmed]
  8. An easter-like serine protease from Anopheles gambiae exhibits changes in transcript abundance following immune challenge. Paskewitz, S.M., Reese-Stardy, S., Gorman, M.J. Insect Mol. Biol. (1999) [Pubmed]
  9. An estimate of the number of serine protease genes expressed in sheep blowfly larvae (Lucilia cuprina). Elvin, C.M., Vuocolo, T., Smith, W.J., Eisemann, C.H., Riddles, P.W. Insect Mol. Biol. (1994) [Pubmed]
  10. Molecular characterization of five serine protease genes cloned from Anopheles gambiae hemolymph. Gorman, M.J., Andreeva, O.V., Paskewitz, S.M. Insect Biochem. Mol. Biol. (2000) [Pubmed]
  11. Recognition of pathogens and activation of immune responses in Drosophila and horseshoe crab innate immunity. Kurata, S., Ariki, S., Kawabata, S. Immunobiology (2006) [Pubmed]
  12. Cloning of a family of serine protease genes from the cat flea Ctenocephalides felis. Gaines, P.J., Sampson, C.M., Rushlow, K.E., Stiegler, G.L. Insect Mol. Biol. (1999) [Pubmed]
  13. Functional dissection of the Drosophila Kallmann's syndrome protein DmKal-1. Andrenacci, D., Grimaldi, M.R., Panetta, V., Riano, E., Rugarli, E.I., Graziani, F. BMC Genet. (2006) [Pubmed]
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