The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Jon99Ci  -  Jonah 99Ci

Drosophila melanogaster

Synonyms: 143341_at, 99Calpha, CG17951, CG31039, Dmel\CG31039, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Jon99Ci

  • Hepatitis C virus (HCV) nonstructural 3 (NS3) serine protease disrupts important cellular antiviral signaling pathways and plays a pivotal role in the proteolytic maturation of the HCV polyprotein precursor [1].
  • Finally, a mutation called disorganization, which is located near the serine protease complex, is of considerable interest because it causes an extraordinarily wide variety of congenital defects [2].

High impact information on Jon99Ci


Biological context of Jon99Ci


Anatomical context of Jon99Ci


Associations of Jon99Ci with chemical compounds


Other interactions of Jon99Ci

  • To activate the pathway, we overexpressed an activated form of the EGFR (UAS-caEGFR), and an activated form of the signal transducer Raf (UAS-caRaf); we also over- or ectopically expressed the downstream homeobox transcription factor Mirror (UAS-mirr) and the ligand-activating serine protease Rhomboid (UAS-rho) [17].
  • The easter gene encodes a serine protease that generates processed Spätzle, which is proposed to act as the Toll ligand [18].
  • The gut-specific sequences encode a maltase, a V-ATPase subunit, a GTP binding protein, two different lectins, and a nontrypsin serine protease [19].
  • Easter is the final protease in a serine protease cascade in which initial reaction steps appear not to be ventrally restricted, but where Easter activity is promoted ventrally through the action of a spatial cue at an unknown step in the pathway [20].
  • Evidence of serine-protease activity closely associated with Drosophila alcohol dehydrogenase [21].

Analytical, diagnostic and therapeutic context of Jon99Ci


  1. Serpin mechanism of hepatitis C virus nonstructural 3 (NS3) protease inhibition: induced fit as a mechanism for narrow specificity. Richer, M.J., Juliano, L., Hashimoto, C., Jean, F. J. Biol. Chem. (2004) [Pubmed]
  2. A complex of serine protease genes expressed preferentially in cytotoxic T-lymphocytes is closely linked to the T-cell receptor alpha- and delta-chain genes on mouse chromosome 14. Crosby, J.L., Bleackley, R.C., Nadeau, J.H. Genomics (1990) [Pubmed]
  3. Multiple extracellular activities in Drosophila egg perivitelline fluid are required for establishment of embryonic dorsal-ventral polarity. Stein, D., Nüsslein-Volhard, C. Cell (1992) [Pubmed]
  4. Dominant and recessive alleles of the Drosophila easter gene are point mutations at conserved sites in the serine protease catalytic domain. Jin, Y.S., Anderson, K.V. Cell (1990) [Pubmed]
  5. A gene required for the specification of dorsal-ventral pattern in Drosophila appears to encode a serine protease. DeLotto, R., Spierer, P. Nature (1986) [Pubmed]
  6. CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals. Jin, S., Kalkum, M., Overholtzer, M., Stoffel, A., Chait, B.T., Levine, A.J. Genes Dev. (2003) [Pubmed]
  7. Levels of RNA from a family of putative serine protease genes are reduced in Drosophila melanogaster dunce mutants and are regulated by cyclic AMP. Yun, Y., Davis, R.L. Mol. Cell. Biol. (1989) [Pubmed]
  8. The serine protease Sp7 is expressed in blood cells and regulates the melanization reaction in Drosophila. Castillejo-López, C., Häcker, U. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  9. Comparative analysis of serine protease-related genes in the honey bee genome: possible involvement in embryonic development and innate immunity. Zou, Z., Lopez, D.L., Kanost, M.R., Evans, J.D., Jiang, H. Insect Mol. Biol. (2006) [Pubmed]
  10. Recombinant prolylcarboxypeptidase activates plasma prekallikrein. Shariat-Madar, Z., Mahdi, F., Schmaier, A.H. Blood (2004) [Pubmed]
  11. The making of a fly leg: a model for epithelial morphogenesis. von Kalm, L., Fristrom, D., Fristrom, J. Bioessays (1995) [Pubmed]
  12. Fluorescently labeled inhibitors detect localized serine protease activities in Drosophila melanogaster pole cells, embryos, and ovarian egg chambers. Jakobsen, R.K., Ono, S., Powers, J.C., DeLotto, R. Histochem. Cell Biol. (2005) [Pubmed]
  13. Induction of a putative serine protease transcript in immune challenged Drosophila. Coustau, C., Rocheleau, T., Carton, Y., Nappi, A.J., ffrench-Constant, R.H. Dev. Comp. Immunol. (1996) [Pubmed]
  14. Association of a protease with polytene chromosomes of Drosophila melanogaster. Cavagnaro, J., Pierce, D.A., Lucchesi, J.C., Chae, C.B. J. Cell Biol. (1980) [Pubmed]
  15. Evidence for the ancient origin of the NF-kappaB/IkappaB cascade: its archaic role in pathogen infection and immunity. Wang, X.W., Tan, N.S., Ho, B., Ding, J.L. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  16. Molecular cloning of cDNA for pro-phenol-oxidase-activating factor I, a serine protease is induced by lipopolysaccharide or 1,3-beta-glucan in coleopteran insect, Holotrichia diomphalia larvae. Lee, S.Y., Cho, M.Y., Hyun, J.H., Lee, K.M., Homma, K.I., Natori, S., Kawabata, S.I., Iwanaga, S., Lee, B.L. Eur. J. Biochem. (1998) [Pubmed]
  17. Genome wide analysis of transcript levels after perturbation of the EGFR pathway in the Drosophila ovary. Jordan, K.C., Hatfield, S.D., Tworoger, M., Ward, E.J., Fischer, K.A., Bowers, S., Ruohola-Baker, H. Dev. Dyn. (2005) [Pubmed]
  18. Regulation of Easter activity is required for shaping the Dorsal gradient in the Drosophila embryo. Chang, A.J., Morisato, D. Development (2002) [Pubmed]
  19. Identification and characterization of differentially expressed cDNAs of the vector mosquito, Anopheles gambiae. Dimopoulos, G., Richman, A., della Torre, A., Kafatos, F.C., Louis, C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  20. Spatially dependent activation of the patterning protease, Easter. LeMosy, E.K. FEBS Lett. (2006) [Pubmed]
  21. Evidence of serine-protease activity closely associated with Drosophila alcohol dehydrogenase. Fibla, J., Atrian, S., Gonzàlez-Duarte, R. Eur. J. Biochem. (1993) [Pubmed]
  22. Interallelic complementation at the Drosophila melanogaster gastrulation defective locus defines discrete functional domains of the protein. Ponomareff, G., Giordano, H., DeLotto, Y., DeLotto, R. Genetics (2001) [Pubmed]
  23. Recognition of pathogens and activation of immune responses in Drosophila and horseshoe crab innate immunity. Kurata, S., Ariki, S., Kawabata, S. Immunobiology (2006) [Pubmed]
WikiGenes - Universities