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PTAFR  -  platelet-activating factor receptor

Ovis aries

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Disease relevance of PAFR


High impact information on PAFR


Biological context of PAFR


Anatomical context of PAFR


Associations of PAFR with chemical compounds

  • We investigated the effects of PAF infusions in unanesthetized sheep and the effects of the PAF receptor antagonist L-652,731 [trans-2,5-bis(3,4,5-trimethoxyphenyl)tetrahydrofuran] on the hematologic, hemodynamic and biochemical alterations produced by infusions of both ZAP and PAF [8].
  • Treatment with CV-3988, a selective PAF receptor antagonist, but not with meclofenamate, atropine, or diphenhydramine and cimetidine blocked the response to PAF infusion and did not affect baseline tone [9].
  • To test the hypothesis that PAF partially mediates endotoxin-induced lung dysfunction, we studied the effects of two structurally dissimilar PAF receptor antagonists (SRI 63-441 and WEB 2086) on endotoxin-induced lung dysfunction in chronically instrumented awake sheep [10].

Analytical, diagnostic and therapeutic context of PAFR


  1. Oxygen-dependent PAF receptor binding and intracellular signaling in ovine fetal pulmonary vascular smooth muscle. Ibe, B.O., Portugal, A.M., Chaturvedi, S., Raj, J.U. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  2. Effects of platelet-activating factor antagonist SRI 63-441 on endotoxemia in sheep. Sessler, C.N., Glauser, F.L., Davis, D., Fowler, A.A. J. Appl. Physiol. (1988) [Pubmed]
  3. Role of platelet-activating factor in the ovine heparin-protamine reaction. Montalescot, G., Huerta, J.M., Braquet, P., Zapol, W.M. J. Appl. Physiol. (1992) [Pubmed]
  4. Mechanisms of glomerular injury in experimental immune nephritis. II. Effect of a platelet activating factor receptor antagonist in an autologous nephritis model. Hruby, Z.W., Lowry, R.P., Forbes, R.D., Blais, D. Arch. Immunol. Ther. Exp. (Warsz.) (1991) [Pubmed]
  5. Components of a platelet-activating factor-signaling loop are assembled in the ovine endometrium late in the estrous cycle. Chami, O., Evans, G., O'Neill, C. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  6. Platelet-activating factor receptors in lamb lungs are downregulated immediately after birth. Ibe, B.O., Sander, F.C., Raj, J.U. Am. J. Physiol. Heart Circ. Physiol. (2000) [Pubmed]
  7. Platelet-activating factor antagonism attenuates platelet and neutrophil activation and reduces myocardial injury during coronary reperfusion. Ko, W., Lang, D., Hawes, A.S., Zelano, J.A., Isom, O.W., Krieger, K.H. J. Surg. Res. (1993) [Pubmed]
  8. Effects of L-652,731, a platelet-activating factor (PAF) receptor antagonist, on PAF- and complement-induced pulmonary hypertension in sheep. Smallbone, B.W., Taylor, N.E., McDonald, J.W. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  9. Fetal pulmonary vasodilation after exogenous platelet-activating factor. Accurso, F.J., Abman, S.H., Wilkening, R.B., Worthen, G.S., Henson, P. J. Appl. Physiol. (1991) [Pubmed]
  10. Effect of platelet-activating factor receptor antagonism on endotoxin-induced lung dysfunction in awake sheep. Christman, B.W., Lefferts, P.L., Blair, I.A., Snapper, J.R. Am. Rev. Respir. Dis. (1990) [Pubmed]
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