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Gene Review

PTGS1  -  prostaglandin-endoperoxide synthase 1...

Ovis aries

Synonyms: COX-1, COX1, PGHS-1
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Disease relevance of PTGS1


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Biological context of PTGS1


Anatomical context of PTGS1


Associations of PTGS1 with chemical compounds


Other interactions of PTGS1


Analytical, diagnostic and therapeutic context of PTGS1


  1. The expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase in ovine maternal uterine and fetal tissues during late gestation and labor. Zhang, Q., Wu, W.X., Brenna, J.T., Nathanielsz, P.W. Endocrinology (1996) [Pubmed]
  2. PIOX, a new pathogen-induced oxygenase with homology to animal cyclooxygenase. Sanz, A., Moreno, J.I., Castresana, C. Plant Cell (1998) [Pubmed]
  3. Reaction of prostaglandin endoperoxide synthase with cis,cis-eicosa-11,14-dienoic acid. Koshkin, V., Dunford, H.B. J. Biol. Chem. (1998) [Pubmed]
  4. Investigation of the role of cysteines in catalysis by prostaglandin endoperoxide synthase. Kennedy, T.A., Smith, C.J., Marnett, L.J. J. Biol. Chem. (1994) [Pubmed]
  5. Prostaglandin endoperoxide synthase substituted with manganese protoporphyrin IX. Formation of a higher oxidation state and its relation to cyclooxygenase reaction. Strieder, S., Schaible, K., Scherer, H.J., Dietz, R., Ruf, H.H. J. Biol. Chem. (1992) [Pubmed]
  6. Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis. Shimokawa, T., Kulmacz, R.J., DeWitt, D.L., Smith, W.L. J. Biol. Chem. (1990) [Pubmed]
  7. Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence. Yokoyama, C., Takai, T., Tanabe, T. FEBS Lett. (1988) [Pubmed]
  8. Orientation of the active site and antigenic determinants of prostaglandin endoperoxide synthase in the endoplasmic reticulum. DeWitt, D.L., Rollins, T.E., Day, J.S., Gauger, J.A., Smith, W.L. J. Biol. Chem. (1981) [Pubmed]
  9. The expression of prostaglandin endoperoxide synthase 2 messenger RNA and the proportion of smooth muscle and collagen in the sheep cervix during the estrous cycle. Kershaw, C.M., Scaramuzzi, R.J., McGowan, M.R., Wheeler-Jones, C.P., Khalid, M. Biol. Reprod. (2007) [Pubmed]
  10. Cellular source in ewes of prostaglandin-endoperoxide synthase-2 in uterine arteries following stimulation with lipopolysaccharide. Vagnoni, K.E., Christiansen, N.D., Holyoak, G.R., Janowiak, M.A., Martin, P.H. Biol. Reprod. (1999) [Pubmed]
  11. Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase). Merlie, J.P., Fagan, D., Mudd, J., Needleman, P. J. Biol. Chem. (1988) [Pubmed]
  12. Oxygenation of 5,8,11-eicosatrienoic acid by prostaglandin endoperoxide synthase and by cytochrome P450 monooxygenase: structure and mechanism of formation of major metabolites. Oliw, E.H., Hörnsten, L., Sprecher, H., Hamberg, M. Arch. Biochem. Biophys. (1993) [Pubmed]
  13. Ontogeny of immunoreactive prostaglandin endoperoxide synthase isoforms in ovine fetal pituitary, hypothalamus and brainstem. Deauseault, D., Giroux, D., Wood, C.E. Neuroendocrinology (2000) [Pubmed]
  14. Differential modification of cyclo-oxygenase and peroxidase activities of prostaglandin endoperoxidase synthase by proteolytic digestion and hydroperoxides. Raz, A., Needleman, P. Biochem. J. (1990) [Pubmed]
  15. Inactivation of prostaglandin endoperoxide synthase by acylating derivatives of indomethacin. Wells, I., Marnett, L.J. Biochemistry (1993) [Pubmed]
  16. A free radical mediated cooxidation of tetramethylhydrazine by prostaglandin hydroperoxidase. Kalyanaraman, B., Sivarajah, K., Eling, T.E., Mason, R.P. Carcinogenesis (1983) [Pubmed]
  17. Mechanism of hydroperoxide reduction by mangano-prostaglandin endoperoxide synthase. Landino, L.M., Marnett, L.J. Biochemistry (1996) [Pubmed]
  18. Prostaglandin endoperoxide synthase-2 abundance is increased in brain tissues of late-gestation fetal sheep in response to cerebral hypoperfusion. Tong, H., Richards, E., Wood, C.E. J. Soc. Gynecol. Investig. (1999) [Pubmed]
  19. In situ hybridization analysis of ovarian prostaglandin endoperoxide synthase mRNA throughout the periovulatory period of the ewe. Murdoch, W.J., Slaughter, R.G., Ji, T.H. Domest. Anim. Endocrinol. (1991) [Pubmed]
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