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Gene Review

CYP7A1  -  cytochrome P450, family 7, subfamily A,...

Sus scrofa

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Disease relevance of CYP7

  • These studies demonstrate 1) premature weaning on day 2 does not prevent neonatal hypercholesterolemia on day 5, 2) premature weaning causes a decrease in hepatic cholesterol 7 alpha-hydroxylase activity that persists into adult life, and 3) dietary cholesterol intake in early life is unable to negate premature weaning-induced changes [1].

High impact information on CYP7


Biological context of CYP7


Anatomical context of CYP7


Associations of CYP7 with chemical compounds


Other interactions of CYP7


Analytical, diagnostic and therapeutic context of CYP7


  1. Premature weaning-induced changes of cholesterol metabolism in guinea pigs. Subbiah, M.T., Yunker, R.L., Menkhaus, A., Poe, B. Am. J. Physiol. (1985) [Pubmed]
  2. Effect of neonatal modulation of cholesterol homeostasis on subsequent response to cholesterol challenge in adult guinea pig. Li, J.R., Bale, L.K., Kottke, B.A. J. Clin. Invest. (1980) [Pubmed]
  3. Bile acids exert negative feedback control on bile acid synthesis in cultured pig hepatocytes by suppression of cholesterol 7 alpha-hydroxylase activity. Kwekkeboom, J., Princen, H.M., van Voorthuizen, E.M., Kempen, H.J. Hepatology (1990) [Pubmed]
  4. Cholesterol is converted to 7 alpha-hydroxy-3-oxo-4-cholestenoic acid in liver mitochondria. Evidence for a mitochondrial sterol 7 alpha-hydroxylase. Axelson, M., Shoda, J., Sjövall, J., Toll, A., Wikvall, K. J. Biol. Chem. (1992) [Pubmed]
  5. 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A). Norlin, M., Toll, A., Björkhem, I., Wikvall, K. J. Lipid Res. (2000) [Pubmed]
  6. Alleles of the cholesterol 7 alpha-hydroxylase (CYP7) gene in pigs selected for high or low plasma total cholesterol. Davis, A.M., Pond, W.G., Wheeler, M., Ishimura-Oka, K., Su, D.R., Li, C.M., Mersmann, H.J. Proc. Soc. Exp. Biol. Med. (1998) [Pubmed]
  7. Hypolipidemic mechanisms of pectin and psyllium in guinea pigs fed high fat-sucrose diets: alterations on hepatic cholesterol metabolism. Vergara-Jimenez, M., Conde, K., Erickson, S.K., Fernandez, M.L. J. Lipid Res. (1998) [Pubmed]
  8. Coordinate regulation of bile acid biosynthetic and recovery pathways. Torchia, E.C., Cheema, S.K., Agellon, L.B. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  9. Developmental changes in cholesterol 7alpha- and 27-hydroxylases in the piglet. Lewis, D.S., Oren, S., Wang, X., Moyer, M.L., Beitz, D.C., Knight, T.J., Mott, G.E. J. Anim. Sci. (2000) [Pubmed]
  10. Effects of superoxide dismutase on cholesterol 7 alpha-hydroxylation in swine. Li, J.R., Kim, D.N. Steroids (1980) [Pubmed]
  11. Studies of the influence of immunological and serological factors from patients with cholestasis due to alcoholic or viral hepatitis on biliary function in the rat. Marbet, U.A., Shefer, S., Leevy, C.M. Eur. J. Clin. Invest. (1984) [Pubmed]
  12. Hypocholesterolemic actions of atorvastatin are associated with alterations on hepatic cholesterol metabolism and lipoprotein composition in the guinea pig. Conde, K., Vergara-Jimenez, M., Krause, B.R., Newton, R.S., Fernandez, M.L. J. Lipid Res. (1996) [Pubmed]
  13. Hepatic 7alpha-hydroxylation of cholesterol in ascorbate-deficient and ascorbate-supplemented guinea pigs. Björkhem, I., Kallner, A. J. Lipid Res. (1976) [Pubmed]
  14. Oxidation of cholesterol and cholesterol analogues by mitochondrial preparations of steroid-hormone-producing tissue. Arthur, J.R., Blair, H.A., Boyd, G.S., Mason, J.I., Suckling, K.E. Biochem. J. (1976) [Pubmed]
  15. Effects of cereals and culture filtrate of Trichoderma viride on lipid metabolism of swine. Qureshi, A.A., Burger, W.C., Elson, C.E., Benevenga, N.J. Lipids (1982) [Pubmed]
  16. Inhibition of the apical sodium-dependent bile acid transporter reduces LDL cholesterol and apoB by enhanced plasma clearance of LDL apoB. Huff, M.W., Telford, D.E., Edwards, J.Y., Burnett, J.R., Barrett, P.H., Rapp, S.R., Napawan, N., Keller, B.T. Arterioscler. Thromb. Vasc. Biol. (2002) [Pubmed]
  17. Influence of chronic ascorbic acid deficiency and excessive ascorbic acid intake on bile acid metabolism and bile composition in the guinea pig. Holloway, D.E., Rivers, J.M. J. Nutr. (1981) [Pubmed]
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