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Chemical Compound Review

CPD-266     (3S,7S,8S,9S,10R,13R,14S,17R)- 10,13...

Synonyms: CHEMBL497207, SureCN281941, AG-F-99106, CHEBI:17500, LMST01010013, ...
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Disease relevance of C03594


High impact information on C03594


Chemical compound and disease context of C03594


Biological context of C03594


Anatomical context of C03594


Associations of C03594 with other chemical compounds


Gene context of C03594


Analytical, diagnostic and therapeutic context of C03594


  1. Serum 7 alpha-hydroxycholesterol reflects hepatic bile acid synthesis in patients with obstructive jaundice after external biliary drainage. Okamoto, S., Fukushima, K., Higashijima, H., Makino, I., Kishinaka, M., Oda, H., Yamashita, H., Ichimiya, H., Chijiiwa, K., Kuroki, S. Hepatology (1994) [Pubmed]
  2. Serum 7 alpha-hydroxycholesterol as a new parameter of liver function in patients with chronic liver diseases. Kuroki, S., Okamoto, S., Naito, T., Oda, H., Nagase, S., Sakai, H., Nawata, H., Yamashita, H., Chijiiwa, K., Tanaka, M. Hepatology (1995) [Pubmed]
  3. An in vivo evaluation of the quantitative significance of several potential pathways to cholic and chenodeoxycholic acids from cholesterol in man. Swell, L., Gustafsson, J., Schwartz, C.C., Halloran, L.G., Danielsson, H., Vlahcevic, Z.R. J. Lipid Res. (1980) [Pubmed]
  4. Esterified and total 7 alpha-hydroxycholesterol in human serum as an indicator for hepatic bile acid synthesis. Oda, H., Yamashita, H., Kosahara, K., Kuroki, S., Nakayama, F. J. Lipid Res. (1990) [Pubmed]
  5. Benign recurrent intrahepatic cholestasis: altered bile acid metabolism. Bijleveld, C.M., Vonk, R.J., Kuipers, F., Havinga, R., Boverhof, R., Koopman, B.J., Wolthers, B.G., Fernandes, J. Gastroenterology (1989) [Pubmed]
  6. Bile acids exert negative feedback control on bile acid synthesis in cultured pig hepatocytes by suppression of cholesterol 7 alpha-hydroxylase activity. Kwekkeboom, J., Princen, H.M., van Voorthuizen, E.M., Kempen, H.J. Hepatology (1990) [Pubmed]
  7. Accumulation of 7 alpha-hydroxycholesterol in liver tissue of patients with cholesterol gallstones. Honda, A., Yoshida, T., Tanaka, N., Matsuzaki, Y., He, B., Shoda, J., Osuga, T. J. Gastroenterol. (1995) [Pubmed]
  8. Cholesterol and bile acid synthesis in Hep G2 cells. Metabolic effects of 26- and 7 alpha-hydroxycholesterol. Javitt, N.B., Budai, K. Biochem. J. (1989) [Pubmed]
  9. Presence of cholesterol 7 alpha-hydroxylase enzyme protein in COS-cells leads to increased HMG CoA reductase activity. Sudjana-Sugiaman, E., Eggertsen, G., Sjöblom, P., Maeda, Y., Rudling, M., Okuda, K., Björkhem, I. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  10. Sex difference in serum 7 alpha-hydroxycholesterol levels in the rat reflect hepatic activity of 3 beta-hydroxy-delta 5-C27-steroid dehydrogenase and cholesterol 7 alpha-hydroxylase. Maeda, Y., Ando, Y., Nagatomo, H., Uchiyama, F., Higashi, S., Setoguchi, T. J. Gastroenterol. (1997) [Pubmed]
  11. Cholesterol metabolism in 8 to 12-year-old children born preterm or at term. Mortaz, M., Fewtrell, M.S., Cole, T.J., Lucas, A. Acta Paediatr. (2003) [Pubmed]
  12. Bile acid synthesis in humans. Swell, L., Gustafsson, J., Danielsson, H., Schwartz, C.C., Halloran, L.G., Vlahcevic, Z.R. Cancer Res. (1981) [Pubmed]
  13. Inhibition of human lymphocyte E-rosette formation by oxygenated sterols. Streuli, R.A., Chung, J., Scanu, A.M., Yachnin, S. J. Immunol. (1979) [Pubmed]
  14. Measurement of cholesterol 7 alpha-hydroxylase activity with selected ion monitoring. Sanghvi, A., Grassi, E., Bartman, C., Lester, R., Galli Kienle, M., Galli, G. J. Lipid Res. (1981) [Pubmed]
  15. Oxygenated cholesterols synergistically immobilize acyl chains and enhance protein helical structure in human erythrocyte membranes. Rooney, M.W., Yachnin, S., Kucuk, O., Lis, L.J., Kauffman, J.W. Biochim. Biophys. Acta (1985) [Pubmed]
  16. Oxysterol regulators of 3-hydroxy-3-methylglutaryl-CoA reductase in liver. Effect of dietary cholesterol. Saucier, S.E., Kandutsch, A.A., Gayen, A.K., Swahn, D.K., Spencer, T.A. J. Biol. Chem. (1989) [Pubmed]
  17. Characteristics of cholesterol 7 alpha-hydroxylase and 7 alpha-hydroxycholesterol hydroxylase activities of rodent liver. Song, W., Pierce, W.M., Prough, R.A., Redinger, R.N. Biochem. Pharmacol. (1991) [Pubmed]
  18. Endogenous 7-oxocholesterol is an enzymatic product: characterization of 7 alpha-hydroxycholesterol dehydrogenase activity of hamster liver microsomes. Song, W., Pierce, W.M., Saeki, Y., Redinger, R.N., Prough, R.A. Arch. Biochem. Biophys. (1996) [Pubmed]
  19. Bile acid synthesis in isolated rat liver cells. The effect of 7 alpha-hydroxycholesterol. Botham, K.M., Beckett, G.J., Percy-Robb, I.W., Boyd, G.S. Eur. J. Biochem. (1980) [Pubmed]
  20. Effect of detergents on in vitro 7 alpha-hydroxycholesterol formation by rat liver microsomes. Sanghvi, A., Grassi, E., Bartman, C., Diven, W.F. Lipids (1982) [Pubmed]
  21. Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1. Zhang, Y., Yu, C., Liu, J., Spencer, T.A., Chang, C.C., Chang, T.Y. J. Biol. Chem. (2003) [Pubmed]
  22. Relationship between the serum concentration of 7 alpha-hydroxycholesterol and fecal bile acid excretion in humans. Hahn, C., von Bergmann, K. Scand. J. Gastroenterol. (1996) [Pubmed]
  23. Isotope derivative assay of microsomal cholesterol 7 alpha-hydroxylase. Shefer, S., Nicolau, G., Mosbach, E.H. J. Lipid Res. (1975) [Pubmed]
  24. Regulation of bile-acid synthesis. Role of sterol carrier protein 2 in the biosynthesis of 7 alpha-hydroxycholesterol. Seltman, H., Diven, W., Rizk, M., Noland, B.J., Chanderbhan, R., Scallen, T.J., Vahouny, G., Sanghvi, A. Biochem. J. (1985) [Pubmed]
  25. From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans. Bjorkhem, I., Andersson, U., Ellis, E., Alvelius, G., Ellegard, L., Diczfalusy, U., Sjovall, J., Einarsson, C. J. Biol. Chem. (2001) [Pubmed]
  26. The effect of oxidizing cholesterol on gastrointestinal absorption, plasma clearance, tissue distribution, and processing by endothelial cells. Krut, L.H., Yang, J.W., Schonfeld, G., Ostlund, R.E. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  27. Use of HPLC for the determination of serum 7 alpha-hydroxycholesterol in cholestyramine-treated rats. Dowling, L., Devery, R. Biochem. Soc. Trans. (1995) [Pubmed]
  28. Serum 7alpha-hydroxycholesterol levels during liver regeneration after hepatectomy in humans. Nakamura, K., Chijiiwa, K., Kuroki, S., Naito, T., Mizuta, A., Tanaka, M. Hepatogastroenterology (2003) [Pubmed]
  29. Effect of diabetes and of 7 alpha-hydroxycholesterol infusion on the profile of bile acids secreted by the isolated rat livers. Ogura, Y., Ito, T., Ogura, M. Biol. Chem. Hoppe-Seyler (1986) [Pubmed]
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