The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ZBTB7B  -  zinc finger and BTB domain containing 7B

Homo sapiens

Synonyms: CKROX, Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, THPOK, ZBTB15, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ZBTB7B

  • Maximal increase in promoter activity in hypoxia was observed between -190 and -174 bp of the proximal promoter, once a cKrox repressor site (-199 to -224 bp) was deleted [1].

High impact information on ZBTB7B

  • The c-Krox protein contains three zinc fingers of the Cys2His2 type. c-Krox binds specifically to a guanine-rich cis-acting element present twice in the promoter element of the mouse alpha 1(I) collagen gene [2].
  • DNA transfection experiments in mouse NIH 3T3 fibroblasts, cells that express the c-Krox gene, or in Drosophila S2 cells, which do not express c-Krox, reveal that c-Krox can activate transcription of a reporter gene linked to several copies of its binding site in the alpha 1(I) collagen promoter [2].
  • c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin [2].
  • The selective spatial pattern of expression of its mRNA and its transcription activation ability suggest that c-Krox may be an important regulator of type I collagen skin specific expression in physiologic conditions and in fibrotic diseases such as scleroderma [2].
  • In addition, OCZF specifically bound to the guanine-rich consensus sequences of Egr-1 and c-Krox [3].

Biological context of ZBTB7B

  • This region was extensively analyzed by DNAse footprinting and electrophoretic mobility shift assays, and a putative binding site for the transcription factor c-Krox was discovered [4].
  • Both contain three kruppel-like zinc-finger DNA binding motifs that are 71-78% identical to those of hcKrox-alpha [5].
  • Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression [6].
  • Transient transfection assays indicate that hcKrox represses transcription of the alpha1(I) procollagen promoter, and electrophoretic mobility shift assays demonstrate that hcKrox binds to both the human and murine promoter DNA [6].
  • In the mouse, cKrox is expressed, beginning at 9.5 days of gestation and at 10.5 days in regions destined to become skin [6].

Anatomical context of ZBTB7B

  • The expression of c-Krox in bone was then examined by reverse-transcribed polymerase chain reaction and Northern blotting analysis; an approximately 3.4 kb transcript was detected in primary osteoblastic cells, in MG-63 cells, and in human bone marrow stromal cells [4].
  • RT-PCR analysis of human fibroblasts indicates constitutive low-level expression of cKrox which can be transiently elevated by treatment with retinoic acid [6].
  • Demethylation of CpG sequences in lymphocytes, in which CpG sequences were heavily methylated, induced CDCP1 expression and its expression level further increased through zfp67 overexpression [7].

Physical interactions of ZBTB7B


Other interactions of ZBTB7B

  • The reporter assay and si-RNA-mediated knockdown experiment revealed that zfp67, a zinc-finger protein, enhanced CDCP1 transcription [7].

Analytical, diagnostic and therapeutic context of ZBTB7B


  1. Low oxygen tension stimulates collagen synthesis and COL1A1 transcription through the action of TGF-beta1. Falanga, V., Zhou, L., Yufit, T. J. Cell. Physiol. (2002) [Pubmed]
  2. c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin. Galéra, P., Musso, M., Ducy, P., Karsenty, G. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. Osteoclast-derived zinc finger (OCZF) protein with POZ domain, a possible transcriptional repressor, is involved in osteoclastogenesis. Kukita, A., Kukita, T., Ouchida, M., Maeda, H., Yatsuki, H., Kohashi, O. Blood (1999) [Pubmed]
  4. Functional characterization of the human biglycan 5'-flanking DNA and binding of the transcription factor c-Krox. Heegaard, A.M., Gehron Robey, P., Vogel, W., Just, W., Widom, R.L., Schøller, J., Fisher, L.W., Young, M.F. J. Bone Miner. Res. (1997) [Pubmed]
  5. The hcKrox gene family regulates multiple extracellular matrix genes. Widom, R.L., Lee, J.Y., Joseph, C., Gordon-Froome, I., Korn, J.H. Matrix Biol. (2001) [Pubmed]
  6. Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression. Widom, R.L., Culic, I., Lee, J.Y., Korn, J.H. Gene (1997) [Pubmed]
  7. Role of DNA methylation for expression of novel stem cell marker CDCP1 in hematopoietic cells. Kimura, H., Morii, E., Ikeda, J.I., Ezoe, S., Xu, J.X., Nakamichi, N., Tomita, Y., Shibayama, H., Kanakura, Y., Aozasa, K. Leukemia (2006) [Pubmed]
WikiGenes - Universities