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Gene Review

CDCP1  -  CUB domain containing protein 1

Homo sapiens

Synonyms: CD318, CUB domain-containing protein 1, Membrane glycoprotein gp140, SIMA135, Subtractive immunization M plus HEp3-associated 135 kDa protein, ...
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Disease relevance of CDCP1


High impact information on CDCP1


Biological context of CDCP1


Anatomical context of CDCP1


Physical interactions of CDCP1

  • Addition of demethylating reagent to Jurkat induced CDCP1 expression, and increased the zfp67 binding to CDCP1 promoter [10].

Other interactions of CDCP1

  • CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin [3].
  • However, CDCP1 was not strictly correlated with CD34 and/or CD133 expression, suggesting that CDCP1 is a novel marker for leukemia diagnosis [3].
  • Tumours with high-level CDCP1 expression showed higher levels of proliferation, as revealed by immunohistochemical detection of the MIB-1 antigen, than tumours with low-level CDCP1 expression [8].
  • The reporter assay and si-RNA-mediated knockdown experiment revealed that zfp67, a zinc-finger protein, enhanced CDCP1 transcription [10].

Analytical, diagnostic and therapeutic context of CDCP1



  1. Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia. Brown, T.A., Yang, T.M., Zaitsevskaia, T., Xia, Y., Dunn, C.A., Sigle, R.O., Knudsen, B., Carter, W.G. J. Biol. Chem. (2004) [Pubmed]
  2. Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. Scherl-Mostageer, M., Sommergruber, W., Abseher, R., Hauptmann, R., Ambros, P., Schweifer, N. Oncogene (2001) [Pubmed]
  3. CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin. Bühring, H.J., Kuçi, S., Conze, T., Rathke, G., Bartolović, K., Grünebach, F., Scherl-Mostageer, M., Brümmendorf, T.H., Schweifer, N., Lammers, R. Stem Cells (2004) [Pubmed]
  4. CDCP1 is a novel marker for hematopoietic stem cells. Conze, T., Lammers, R., Kuci, S., Scherl-Mostageer, M., Schweifer, N., Kanz, L., Buhring, H.J. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  5. The C2 domain of PKCdelta is a phosphotyrosine binding domain. Benes, C.H., Wu, N., Elia, A.E., Dharia, T., Cantley, L.C., Soltoff, S.P. Cell (2005) [Pubmed]
  6. Leonard Trask: the wonderful invalid: the first American description of ankylosing spondylitis. Jayson, M.I. Arthritis Rheum. (2003) [Pubmed]
  7. Adhesion signaling by a novel mitotic substrate of src kinases. Bhatt, A.S., Erdjument-Bromage, H., Tempst, P., Craik, C.S., Moasser, M.M. Oncogene (2005) [Pubmed]
  8. Epigenetic regulation of the expression of the novel stem cell marker CDCP1 in cancer cells. Ikeda, J.I., Morii, E., Kimura, H., Tomita, Y., Takakuwa, T., Hasegawa, J.I., Kim, Y.K., Miyoshi, Y., Noguchi, S., Nishida, T., Aozasa, K. J. Pathol. (2006) [Pubmed]
  9. Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. Hooper, J.D., Zijlstra, A., Aimes, R.T., Liang, H., Claassen, G.F., Tarin, D., Testa, J.E., Quigley, J.P. Oncogene (2003) [Pubmed]
  10. Role of DNA methylation for expression of novel stem cell marker CDCP1 in hematopoietic cells. Kimura, H., Morii, E., Ikeda, J.I., Ezoe, S., Xu, J.X., Nakamichi, N., Tomita, Y., Shibayama, H., Kanakura, Y., Aozasa, K. Leukemia (2006) [Pubmed]
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