Gene Review:
PLAUR - plasminogen activator, urokinase receptor
Homo sapiens
Synonyms:
CD87, MO3, Monocyte activation antigen Mo3, U-PAR, UPAR, ...
Mathiesen,
Blackwood,
Harper,
Melero,
Galappathi,
Todd,
Meyermann,
Preissner,
Schmidt,
Stephens,
Jerke,
Magdolen,
Jamaluddin,
Farquhar,
Neumann,
Haller,
Sreerama Shetty,
Steven Idell,
Bouvet,
Luther,
Deininger,
Aguirre-Ghiso,
García-Barreno,
Rofstad,
Kanse,
Chavakis,
Mayboroda,
Domínguez,
Ossowski,
Tkachuk,
Schömig,
Sitrin,
Martínez,
Gulba,
Vogel,
Rashmi S. Shetty,
Schluesener,
Dumler,
Orlando,
May,
Trautmann,
Stepanova,
Pan,
Praveenkumar Shetty,
Kuemmel,
Thirunavukkarasu Velusamy,
Andrew P. Mazar,
Lombardía,
Czekay,
Yashodhar P. Bhandary,
Harsh,
- Urokinase receptor expression on human microvascular endothelial cells is increased by hypoxia: implications for capillary-like tube formation in a fibrin matrix. Kroon, M.E., Koolwijk, P., van der Vecht, B., van Hinsbergh, V.W. Blood (2000)
- Urokinase plasminogen activator receptor (uPA-R): one potential characteristic of metastatic phenotypes in minimal residual tumor disease. Allgayer, H., Heiss, M.M., Riesenberg, R., Grützner, K.U., Tarabichi, A., Babic, R., Schildberg, F.W. Cancer Res. (1997)
- Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function. Simon, D.I., Wei, Y., Zhang, L., Rao, N.K., Xu, H., Chen, Z., Liu, Q., Rosenberg, S., Chapman, H.A. J. Biol. Chem. (2000)
- The role of urokinase-type plasminogen activator (uPA)/uPA receptor in HIV-1 infection. Alfano, M., Sidenius, N., Blasi, F., Poli, G. J. Leukoc. Biol. (2003)
- uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells. Lester, R.D., Jo, M., Montel, V., Takimoto, S., Gonias, S.L. J. Cell Biol. (2007)
- Differential proteome expression associated with urokinase plasminogen activator receptor (uPAR) suppression in malignant epithelial cancer. Saldanha, R.G., Xu, N., Molloy, M.P., Veal, D.A., Baker, M.S. J. Proteome Res. (2008)
- Expression of the urokinase plasminogen activator and its receptor in HIV-1-associated central nervous system disease. Sidenius, N., Nebuloni, M., Sala, S., Zerbi, P., Price, R.W., Gisslen, M., Hagberg, L., Vago, L., Lazzarin, A., Blasi, F., Cinque, P. J. Neuroimmunol. (2004)
- Cortical neurons of Creutzfeldt-Jakob disease patients express the urokinase-type plasminogen activator receptor. Deininger, M.H., Trautmann, K., Magdolen, V., Luther, T., Schluesener, H.J., Meyermann, R. Neurosci. Lett. (2002)
- Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay. Kim, J., Yu, W., Kovalski, K., Ossowski, L. Cell (1998)
- Individual development and uPA-receptor expression of disseminated tumour cells in bone marrow: a reference to early systemic disease in solid cancer. Heiss, M.M., Allgayer, H., Gruetzner, K.U., Funke, I., Babic, R., Jauch, K.W., Schildberg, F.W. Nat. Med. (1995)
- Regulation of integrin function by the urokinase receptor. Wei, Y., Lukashev, M., Simon, D.I., Bodary, S.C., Rosenberg, S., Doyle, M.V., Chapman, H.A. Science (1996)
- Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth. Ossowski, L., Aguirre-Ghiso, J.A. Curr. Opin. Cell Biol. (2000)
- Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of Mac-1(CD11b/CD18) and urokinase receptor (CD87). Wong, W.S., Simon, D.I., Rosoff, P.M., Rao, N.K., Chapman, H.A. Immunology (1996)
- Increased metastatic dissemination in human melanoma xenografts after subcurative radiation treatment: radiation-induced increase in fraction of hypoxic cells and hypoxia-induced up-regulation of urokinase-type plasminogen activator receptor. Rofstad, E.K., Mathiesen, B., Galappathi, K. Cancer Res. (2004)
- Lipids isolated from bone induce the migration of human breast cancer cells. Silva, J., Dasgupta, S., Wang, G., Krishnamurthy, K., Ritter, E., Bieberich, E. J. Lipid Res. (2006)
- Aspirin upregulates expression of urokinase type plasminogen activator receptor (uPAR) gene in human colon cancer cells through AP1. Jamaluddin, M.S. Biochem. Biophys. Res. Commun. (2006)
- Interleukin-1beta-induced expression of the urokinase-type plasminogen activator receptor and its co-localization with MMPs in human articular chondrocytes. Schwab, W., Schulze-Tanzil, G., Mobasheri, A., Dressler, J., Kotzsch, M., Shakibaei, M. Histol. Histopathol. (2004)
- Assignment of the urokinase-type plasminogen activator receptor gene (PLAUR) to chromosome 19q13.1-q13.2. Børglum, A.D., Byskov, A., Ragno, P., Roldan, A.L., Tripputi, P., Cassani, G., Danø, K., Blasi, F., Bolund, L., Kruse, T.A. Am. J. Hum. Genet. (1992)
- Distinct gene subsets are induced at different time points after human respiratory syncytial virus infection of A549 cells. Martínez, I., Lombardía, L., García-Barreno, B., Domínguez, O., Melero, J.A. J. Gen. Virol. (2007)
- Assignment of the human urokinase receptor gene (PLAUR) to 19q13. Vagnarelli, P., Raimondi, E., Mazzieri, R., De Carli, L., Mignatti, P. Cytogenet. Cell Genet. (1992)
- Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release? Deng, G., Curriden, S.A., Wang, S., Rosenberg, S., Loskutoff, D.J. J. Cell Biol. (1996)
- Vitronectin concentrates proteolytic activity on the cell surface and extracellular matrix by trapping soluble urokinase receptor-urokinase complexes. Chavakis, T., Kanse, S.M., Yutzy, B., Lijnen, H.R., Preissner, K.T. Blood (1998)
- Urokinase receptor surface expression regulates monocyte adhesion in acute myocardial infarction. May, A.E., Schmidt, R., Kanse, S.M., Chavakis, T., Stephens, R.W., Schömig, A., Preissner, K.T., Neumann, F.J. Blood (2002)
- Convergence of the adhesive and fibrinolytic systems: recognition of urokinase by integrin alpha Mbeta 2 as well as by the urokinase receptor regulates cell adhesion and migration. Pluskota, E., Soloviev, D.A., Plow, E.F. Blood (2003)
- Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding. Wei, Y., Czekay, R.P., Robillard, L., Kugler, M.C., Zhang, F., Kim, K.K., Xiong, J.P., Humphries, M.J., Chapman, H.A. J. Cell Biol. (2005)
- Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells. Simon, D.I., Rao, N.K., Xu, H., Wei, Y., Majdic, O., Ronne, E., Kobzik, L., Chapman, H.A. Blood (1996)
- Vascular endothelial growth factor enhances the expression of urokinase receptor in human endothelial cells via protein kinase C activation. Kroon, M.E., Koolwijk, P., Vermeer, M.A., van der Vecht, B., van Hinsbergh, V.W. Thromb. Haemost. (2001)
- A dual role for caveolin-1 in the regulation of fibronectin matrix assembly by uPAR. Monaghan-Benson, E., Mastick, C.C., McKeown-Longo, P.J. J. Cell. Sci. (2008)
- Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes. Nykjaer, A., Petersen, C.M., Møller, B., Jensen, P.H., Moestrup, S.K., Holtet, T.L., Etzerodt, M., Thøgersen, H.C., Munch, M., Andreasen, P.A. J. Biol. Chem. (1992)
- Urokinase-type plasminogen activator/type-2 plasminogen-activator inhibitor complexes are not internalized upon binding to the urokinase-type-plasminogen-activator receptor in THP-1 cells. Interaction of urokinase-type plasminogen activator/type-2 plasminogen-activator inhibitor complexes with the cell surface. Ragno, P., Montuori, N., Rossi, G. Eur. J. Biochem. (1995)
- Binding of urokinase-type plasminogen activator receptor (uPAR) to the mannose 6-phosphate/insulin-like growth factor II receptor: contrasting interactions of full-length and soluble forms of uPAR. Kreiling, J.L., Byrd, J.C., Deisz, R.J., Mizukami, I.F., Todd, R.F., MacDonald, R.G. J. Biol. Chem. (2003)
- The cleavage of the urokinase receptor regulates its multiple functions. Montuori, N., Carriero, M.V., Salzano, S., Rossi, G., Ragno, P. J. Biol. Chem. (2002)
- Urokinase-dependent human vascular smooth muscle cell adhesion requires selective vitronectin phosphorylation by ectoprotein kinase CK2. Stepanova, V., Jerke, U., Sagach, V., Lindschau, C., Dietz, R., Haller, H., Dumler, I. J. Biol. Chem. (2002)
- Subcellular distribution of urokinase and urokinase receptor in human neutrophils determined by immunoelectron microscopy. Pedersen, T.L., Plesner, T., Horn, T., Høyer-Hansen, G., Sørensen, S., Hansen, N.E. Ultrastructural pathology. (2000)
- The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae. Stahl, A., Mueller, B.M. J. Cell Biol. (1995)
- Urokinase-induced mitogenesis is mediated by casein kinase 2 and nucleolin. Dumler, I., Stepanova, V., Jerke, U., Mayboroda, O.A., Vogel, F., Bouvet, P., Tkachuk, V., Haller, H., Gulba, D.C. Curr. Biol. (1999)
- Expression of plasminogen activator and inhibitor, urokinase receptor and inhibin subunits in rhesus monkey testes. Zhang, T., Zhou, H.M., Liu, Y.X. Mol. Hum. Reprod. (1997)
- Human retinal pigment epithelial lysis of extracellular matrix: functional urokinase plasminogen activator receptor, collagenase, and elastase. Elner, S.G. Transactions of the American Ophthalmological Society. (2002)
- Regulation of urokinase receptor proteolytic function by the tetraspanin CD82. Bass, R., Werner, F., Odintsova, E., Sugiura, T., Berditchevski, F., Ellis, V. J. Biol. Chem. (2005)
- The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes. Sitrin, R.G., Todd, R.F., Albrecht, E., Gyetko, M.R. J. Clin. Invest. (1996)
- Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta. Kiyan, J., Kiyan, R., Haller, H., Dumler, I. EMBO J. (2005)
- Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells. Mahdi, F., Shariat-Madar, Z., Todd, R.F., Figueroa, C.D., Schmaier, A.H. Blood (2001)
- Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity. Czekay, R.P., Kuemmel, T.A., Orlando, R.A., Farquhar, M.G. Mol. Biol. Cell (2001)
- Regulation of urokinase receptor expression by p53: novel role in stabilization of uPAR mRNA. Shetty, S., Velusamy, T., Idell, S., Shetty, P., Mazar, A.P., Bhandary, Y.P., Shetty, R.S. Mol. Cell. Biol. (2007)
- Clustering of urokinase receptors (uPAR; CD87) induces proinflammatory signaling in human polymorphonuclear neutrophils. Sitrin, R.G., Pan, P.M., Harper, H.A., Todd, R.F., Harsh, D.M., Blackwood, R.A. J. Immunol. (2000)