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Gene Review

Camkk1  -  calcium/calmodulin-dependent protein...

Mus musculus

Synonyms: AI846603, CaM-KK 1, CaM-KK alpha, CaM-kinase IV kinase, CaM-kinase kinase 1, ...
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Disease relevance of Camkk1

  • Using a combination of pharmacological inhibitors and dominant-negative kinases (dnKinase), we identified a requirement for CaMKK acting through CaMKI in the stimulation of ERKs upon depolarization of the neuroblastoma cell line, NG108 [1].
  • Although recombinant CaMKIx expressed in Escherichia coli showed no protein kinase activity against syntide-2, a synthetic peptide substrate, it was activated when phosphorylated by mouse Ca(2+)/calmodulin-dependent protein kinase kinase alpha (CaMKKalpha) [2].

High impact information on Camkk1


Biological context of Camkk1


Anatomical context of Camkk1


Other interactions of Camkk1

  • CREB can be activated by both protein kinase A and by Ca2+-calmodulin-dependent protein kinases (CaMKs), which are in turn phosphorylated by their upstream activators CaMKKalpha and CaMMKKbeta [8].


  1. Calcium activation of ERK mediated by calmodulin kinase I. Schmitt, J.M., Wayman, G.A., Nozaki, N., Soderling, T.R. J. Biol. Chem. (2004) [Pubmed]
  2. Cloning and characterization of a novel Ca2+/calmodulin-dependent protein kinase I homologue in Xenopus laevis. Kinoshita, S., Sueyoshi, N., Shoju, H., Suetake, I., Nakamura, M., Tajima, S., Kameshita, I. J. Biochem. (2004) [Pubmed]
  3. Ca2+/Calmodulin Kinase Kinase {alpha} Is Dispensable for Brain Development but Is Required for Distinct Memories in Male, though Not in Female, Mice. Mizuno, K., Ris, L., S??nchez-Capelo, A., Godaux, E., Giese, K.P. Mol. Cell. Biol. (2006) [Pubmed]
  4. Long-Term Memory Deficits in Pavlovian Fear Conditioning in Ca2+/Calmodulin Kinase Kinase {alpha}-Deficient Mice. Blaeser, F., Sanders, M.J., Truong, N., Ko, S., Wu, L.J., Wozniak, D.F., Fanselow, M.S., Zhuo, M., Chatila, T.A. Mol. Cell. Biol. (2006) [Pubmed]
  5. The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. Hurley, R.L., Anderson, K.A., Franzone, J.M., Kemp, B.E., Means, A.R., Witters, L.A. J. Biol. Chem. (2005) [Pubmed]
  6. Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase alpha as Snf1-activating kinases in yeast. Hong, S.P., Momcilovic, M., Carlson, M. J. Biol. Chem. (2005) [Pubmed]
  7. Modulation of a calcium/calmodulin-dependent protein kinase cascade by retinoic acid during neutrophil maturation. Lawson, N.D., Zain, M., Zibello, T., Picciotto, M.R., Nairn, A.C., Berliner, N. Exp. Hematol. (1999) [Pubmed]
  8. Chronic treatment with desipramine and fluoxetine modulate BDNF, CaMKKalpha and CaMKKbeta mRNA levels in the hippocampus of transgenic mice expressing antisense RNA against the glucocorticoid receptor. Vinet, J., Carra, S., Blom, J.M., Brunello, N., Barden, N., Tascedda, F. Neuropharmacology (2004) [Pubmed]
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