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Chemical Compound Review

MES solution     2-morpholin-4-ylethanesulfonic acid

Synonyms: MOPS solution, ARONIS023604, AG-A-31508, mes (buffer), ACMC-209jx2, ...
 
 
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Disease relevance of Solvent

 

Psychiatry related information on Solvent

  • Comprehensive data regarding psychiatric diagnosis and drug use were gathered using the Home Environment Lifetime Psychiatric Record. Solvent abuse was very strongly associated with having a diagnosis of Antisocial Personality Disorder and was consistently associated with polysubstance abuse [6].
 

High impact information on Solvent

 

Chemical compound and disease context of Solvent

 

Biological context of Solvent

  • Buffering of the 10 microM 2,4-D-containing culture medium by 10 mM 2-(N-morpholino)ethanesulfonic acid delayed cell division and resulted in nonembryogenic cell-type formation [13].
  • (ii) Solvent deuterium isotope effects for hydrolysis of Z-Gln-Gly by gpTGase are (D)(k(c)/K(m)) = 0.45 and (D)k(c) = 3 [14].
  • Hydrogen-tritium exchange kinetics of soybean trypsin inhibitor (Kunitz). Solvent accessibility in the folded conformation [15].
  • (iii) Solvent isotope effects are (D)K(assoc) = 0.5 and (D)k(2) = 0.9, suggesting that the substrate binds to a form of free enzyme in which the active site Cys exists as the thiol [16].
  • Highly Enantioselective Hydrogenation of alpha-Dehydroamino Esters and Itaconates with Triphosphorous Bidentate Ligands and the Unprecedented Solvent Effect Thereof [17].
 

Anatomical context of Solvent

 

Associations of Solvent with other chemical compounds

 

Gene context of Solvent

 

Analytical, diagnostic and therapeutic context of Solvent

  • Serum samples were stabilized with 0.5 M morpholineethanesulfonic acid buffer (pH 6.0) and subjected to ultrafiltration before chromatography [33].
  • Influence of the Solvent Environment on the Contact Mechanics of Tip-Sample Interactions in Friction Force Microscopy of Poly(ethylene terephthalate) Films [34].
  • INTERPRETATION: Solvent-treated freeze-dried bone from femoral heads procured during arthroplasty for sub-capital hip fractures represents a valuable source of material for allografts, addressing concerns regarding serological testing, medical history and bone quality [35].
  • We have modified the method to decrease its cost and increase laboratory efficiency by: (1) automating the extraction by using Accelerated Solvent Extraction (ASE); and (2) by scaling and automating the precipitation reaction, chromatography, and spectrometry with microplate gel filtration and an automated UV-VIS microplate spectrometer [36].
  • RESULTS: Solvent-exposed children had significantly higher error scores on red-green and blue-yellow color discrimination, as well as poorer visual acuity compared with the control group [37].

References

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  2. Suppression of HIV-1 Protease Inhibitor Resistance by Phosphonate-mediated Solvent Anchoring. Cihlar, T., He, G.X., Liu, X., Chen, J.M., Hatada, M., Swaminathan, S., McDermott, M.J., Yang, Z.Y., Mulato, A.S., Chen, X., Leavitt, S.A., Stray, K.M., Lee, W.A. J. Mol. Biol. (2006) [Pubmed]
  3. Unanticipated inhibition of the metallo-beta-lactamase from Bacteroides fragilis by 4-morpholineethanesulfonic acid (MES): a crystallographic study at 1.85-A resolution. Fitzgerald, P.M., Wu, J.K., Toney, J.H. Biochemistry (1998) [Pubmed]
  4. Catalytic cycle of the phosphatidylcholine-preferring phospholipase C from Bacillus cereus. Solvent viscosity, deuterium isotope effects, and proton inventory studies. Martin, S.F., Hergenrother, P.J. Biochemistry (1999) [Pubmed]
  5. Petroleum hydrocarbon toxicity studies. VI. Animal and human responses to vapors of "60 Solvent". Carpenter, C.P., Kinkead, E.R., Geary, D.L., Sullivan, L.J., King, J.M. Toxicol. Appl. Pharmacol. (1975) [Pubmed]
  6. The relationship of solvent use to other substance use. Dinwiddie, S.H., Reich, T., Cloninger, C.R. The American journal of drug and alcohol abuse. (1991) [Pubmed]
  7. pH dependence of mitomycin C-induced cross-linking activity in EMT6 tumor cells. Kennedy, K.A., McGurl, J.D., Leondaridis, L., Alabaster, O. Cancer Res. (1985) [Pubmed]
  8. Role of Cl- in electrogenic Na+-coupled cotransporters GAT1 and SGLT1. Loo, D.D., Eskandari, S., Boorer, K.J., Sarkar, H.K., Wright, E.M. J. Biol. Chem. (2000) [Pubmed]
  9. Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau. Greenberg, S.G., Davies, P., Schein, J.D., Binder, L.I. J. Biol. Chem. (1992) [Pubmed]
  10. Hydrophobic surfaces of tubulin probed by time-resolved and steady-state fluorescence of nile red. Sackett, D.L., Knutson, J.R., Wolff, J. J. Biol. Chem. (1990) [Pubmed]
  11. Interaction of tubulin and cellular microtubules with the new antitumor drug MDL 27048. A powerful and reversible microtubule inhibitor. Peyrot, V., Leynadier, D., Sarrazin, M., Briand, C., Rodriquez, A., Nieto, J.M., Andreu, J.M. J. Biol. Chem. (1989) [Pubmed]
  12. Allergic contact dermatitis from a perinone-type dye C.I. Solvent Orange 60 in spectacle frames. Shono, M., Kaniwa, M.A. Contact Derm. (1999) [Pubmed]
  13. The Role of auxin, pH, and stress in the activation of embryogenic cell division in leaf protoplast-derived cells of alfalfa. Pasternak, T.P., Prinsen, E., Ayaydin, F., Miskolczi, P., Potters, G., Asard, H., Van Onckelen, H.A., Dudits, D., Fehér, A. Plant Physiol. (2002) [Pubmed]
  14. Kinetic analysis of the action of tissue transglutaminase on peptide and protein substrates. Case, A., Stein, R.L. Biochemistry (2003) [Pubmed]
  15. Hydrogen-tritium exchange kinetics of soybean trypsin inhibitor (Kunitz). Solvent accessibility in the folded conformation. Ellis, L.M., Bloomfield, V.A., Woodward, C.K. Biochemistry (1975) [Pubmed]
  16. Mechanistic studies of ubiquitin C-terminal hydrolase L1. Case, A., Stein, R.L. Biochemistry (2006) [Pubmed]
  17. Highly Enantioselective Hydrogenation of alpha-Dehydroamino Esters and Itaconates with Triphosphorous Bidentate Ligands and the Unprecedented Solvent Effect Thereof. Zhang, W., Zhang, X. J. Org. Chem. (2007) [Pubmed]
  18. An intermediate polymer in the assembly of clathrin baskets. Prasad, K., Lippoldt, R.E., Edelhoch, H., Lewis, M.S. Biochemistry (1986) [Pubmed]
  19. Stereoselectivity of the guanyl-exchangeable nucleotide-binding site of tubulin probed by guanosine 5'-O-(2-thiotriphosphate) diastereoisomers. Roychowdhury, S., Gaskin, F. Biochemistry (1988) [Pubmed]
  20. Liquid diffraction analysis of sarcoplasmic reticulum. II. Solvent electron contrast variation. Brady, G.W., Fein, D.B., Meissner, G., Harder, M.E. Biophys. J. (1982) [Pubmed]
  21. A prospective randomized trial using solvent dehydrated fascia lata for the prevention of recurrent anterior vaginal wall prolapse. Gandhi, S., Goldberg, R.P., Kwon, C., Koduri, S., Beaumont, J.L., Abramov, Y., Sand, P.K. Am. J. Obstet. Gynecol. (2005) [Pubmed]
  22. Analysis of cholesterol oxides in egg yolk and turkey meat. Ahn, D.U., Lee, J.I., Jo, C., Sell, J.L. Poult. Sci. (1999) [Pubmed]
  23. A calorimetric investigation of the binding of indole and phenylethane boronic acid to chymotrypsin. Jones, J.B., Trowbridge, C.G. J. Biol. Chem. (1983) [Pubmed]
  24. Nitrate does not result in iron inactivation in the apoplast of sunflower leaves. Nikolic, M., Römheld, V. Plant Physiol. (2003) [Pubmed]
  25. Interaction of basic compounds with coated vesicles. Di Cerbo, A., Nandi, P.K., Edelhoch, H. Biochemistry (1984) [Pubmed]
  26. An improved sodium dodecyl sulfate-polyacrylamide gel electrophoresis system for the analysis of membrane protein complexes. Kashino, Y., Koike, H., Satoh, K. Electrophoresis (2001) [Pubmed]
  27. Regiospecific and Highly Stereoselective Coupling of 6-(Substituted-imidazol-1-yl)purines with 2-Deoxy-3,5-di-O-(p-toluoyl)-alpha-d-erythro-pentofuranosyl Chloride. Sodium-Salt Glycosylation in Binary Solvent Mixtures: Improved Synthesis of Cladribine(1). Zhong, M., Nowak, I., Robins, M.J. J. Org. Chem. (2006) [Pubmed]
  28. Evaluation of pharmacokinetics, efficacy and safety of Immunate((R)) solvent detergent in previously treated patients with severe haemophilia A. Nemes, L., Lissitchkov, T., Klukowska, A., Dobaczewski, G., Komrska, V., Zimmermann, R., Auerswald, G., Engl, W., Pavlova, B., Abb??hl, B., Ehrlich, H.J. Haemophilia : the official journal of the World Federation of Hemophilia (2007) [Pubmed]
  29. Three-electrode electrochemical detector and platinum film decoupler integrated with a capillary electrophoresis microchip for amperometric detection. Wu, C.C., Wu, R.G., Huang, J.G., Lin, Y.C., Hsien-Chang, C. Anal. Chem. (2003) [Pubmed]
  30. Sensitization of heat-treated Listeria monocytogenes to added lysozyme in milk. Kihm, D.J., Leyer, G.J., An, G.H., Johnson, E.A. Appl. Environ. Microbiol. (1994) [Pubmed]
  31. Petroleum hydrocarbon toxicity studies. VIII. Animal and human response to vapors of "140 degrees Flash Aliphatic Solvent". Carpenter, C.P., Kinkead, E.R., Geary, D.L., Sullivan, L.J., King, J.M. Toxicol. Appl. Pharmacol. (1975) [Pubmed]
  32. Crystallographic analysis of the NNA7 Fab and proposal for the mode of human blood-group recognition. Xie, K., Song, S.C., Spitalnik, S.L., Wedekind, J.E. Acta Crystallogr. D Biol. Crystallogr. (2005) [Pubmed]
  33. Determination of imipenem and cilastatin in serum by high-pressure liquid chromatography. Myers, C.M., Blumer, J.L. Antimicrob. Agents Chemother. (1984) [Pubmed]
  34. Influence of the Solvent Environment on the Contact Mechanics of Tip-Sample Interactions in Friction Force Microscopy of Poly(ethylene terephthalate) Films. Hurley, C.R., Leggett, G.J. Langmuir : the ACS journal of surfaces and colloids. (2006) [Pubmed]
  35. Neck fracture femoral heads for impaction bone grafting: evolution of stiffness and compactness during impaction of osteoarthrotic and neck-fracture femoral heads. Cornu, O., Manil, O., Godts, B., Naets, B., Van Tomme, J., Delloye, C., Banse, X. Acta orthopaedica Scandinavica. (2004) [Pubmed]
  36. A modified method for determining tannin-protein precipitation capacity using accelerated solvent extraction (ASE) and microplate gel filtration. McArt, S.H., Spalinger, D.E., Kennish, J.M., Collins, W.B. J. Chem. Ecol. (2006) [Pubmed]
  37. Effects of maternal occupational exposure to organic solvents on offspring visual functioning: a prospective controlled study. Till, C., Westall, C.A., Rovet, J.F., Koren, G. Teratology (2001) [Pubmed]
 
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