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Gene Review

Ptges3  -  prostaglandin E synthase 3 (cytosolic)

Mus musculus

Synonyms: 5730442A20Rik, Cytosolic prostaglandin E2 synthase, Hsp90 co-chaperone, Progesterone receptor complex p23, Prostaglandin E synthase 3, ...
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High impact information on Ptges3


Biological context of Ptges3

  • The cPGES gene promoter is GC-rich and contains many SP1 sites but lacks an obvious TATA box motif [4].
  • Analysis of a cPGES cDNA with partially sequenced cPGES genomic clones and bioinformatic databases demonstrates that the murine cPGES gene spans approximately 22 kb and consists of eight exons [4].

Anatomical context of Ptges3


Analytical, diagnostic and therapeutic context of Ptges3


  1. The hsp90 Co-chaperone XAP2 alters importin beta recognition of the bipartite nuclear localization signal of the Ah receptor and represses transcriptional activity. Petrulis, J.R., Kusnadi, A., Ramadoss, P., Hollingshead, B., Perdew, G.H. J. Biol. Chem. (2003) [Pubmed]
  2. Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases. Longshaw, V.M., Chapple, J.P., Balda, M.S., Cheetham, M.E., Blatch, G.L. J. Cell. Sci. (2004) [Pubmed]
  3. Cyclooxygenases and prostaglandin E synthases in preimplantation mouse embryos. Tan, H.N., Liu, Y., Diao, H.L., Yang, Z.M. Zygote (2005) [Pubmed]
  4. Genomic structure and genitourinary expression of mouse cytosolic prostaglandin E(2) synthase gene. Zhang, Y., Schneider, A., Rao, R., Lu, W.J., Fan, X., Davis, L., Breyer, R.M., Breyer, M.D., Guan, Y. Biochim. Biophys. Acta (2003) [Pubmed]
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